| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Bjarte Fosby, Sigrid Næss, Johannes R Hov, James Traherne, Kirsten M Boberg, John Trowsdale, Aksel Foss, Pål-Dag Line, Andre Franke, Espen Melum, Helge Scott and Tom H Karlsen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Norwegian PSC Research Center |
|
| Wellcome Trust and the MRC with additional support from the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre |
to Traherne J and Trowsdale J |
|
| Corresponding Author |
Tom H Karlsen, MD, PhD, Professor, Norwegian PSC Research Center, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Pb 4950 Nydalen, N-0424 Oslo, Norway. t.h.karlsen@medisin.uio.no |
| Key Words |
Liver transplantation; Primary sclerosing cholangitis; Acute rejection; Human leukocyte antigen; Killer immunoglobulin-like receptor |
| Core Tip |
Patients undergoing liver transplantation on the basis of primary sclerosing cholangitis (PSC) have a higher frequency of acute cellular rejections than non-PSC patients. Recent studies have determined the genetic susceptibility to PSC, of which genetic variants in the human leukocyte antigen complex represent the strongest risk factors. In the present report we show that these variants also influence risk of acute cellular rejection after liver transplantation in PSC. Moreover, we show that the same variants also involve in risk of acute cellular rejection in non-PSC recipients. |
| Publish Date |
2014-04-14 10:49 |
| Citation |
Fosby B, N?ss S, Hov JR, Traherne J, Boberg KM, Trowsdale J, Foss A, Line PD, Franke A, Melum E, Scott H, Karlsen TH. HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation. World J Gastroenterol 2014; 20(14): 3986-4000 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i14/3986.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i14.3986 |
