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9/16/2022 11:52:43 AM | Browse: 93 | Download: 106
Publication Name World Journal of Clinical Cases
Manuscript ID 78469
Country/Territory Greece
2022-06-28 11:49
Peer-Review Started
2022-06-28 11:51
To Make the First Decision
Return for Revision
2022-07-14 03:35
2022-07-16 09:12
Second Decision
2022-08-17 03:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-08-17 21:11
Articles in Press
2022-08-17 21:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-08-30 20:04
Publish the Manuscript Online
2022-09-16 11:52
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Molecular factors, diagnosis and management of gastrointestinal tract neuroendocrine tumors: An update
Manuscript Source Invited Manuscript
All Author List Efstathios Theodoros Pavlidis and Theodoros Efstathios Pavlidis
Author(s) ORCID Number
Efstathios Theodoros Pavlidis http://orcid.org/0000-0002-7282-8101
Theodoros Efstathios Pavlidis http://orcid.org/0000-0002-8141-1412
Funding Agency and Grant Number
Corresponding Author Theodoros Efstathios Pavlidis, Doctor, PhD, Chief Doctor, Director, Full Professor, Surgeon, Department of 2nd Surgical Propedeutic, Aristotle University of Thessaloniki, School of Medicine, Konstantinoupoleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr
Key Words Gastrointestinal neuroendocrine tumors; Neuroendocrine neoplasms; Mixed NEN; Neuroendocrine carcinoma; APUD cells; Carcinoids; Somatostatin analogs
Core Tip Novel diagnostic modalities, including imaging, biomarkers and molecular factors such as liquid biopsy based on mRNA and NETest index, including 51 genes, have changed diagnosis and follow-up. Current available therapeutic options for gastrointestinal neuroendocrine tumors open new horizons promising better results. Surgery remains the cornerstone for resectable disease, but drug therapies, mainly somatostatin analogs, somatostatin receptor antagonists, molecular-targeted drugs and new chemotherapeutic agents are important in the palliative treatment of inoperable or recurrent cases. Advances in genomic profiling and endoscopic intervention could individualize management options.
Publish Date 2022-09-16 11:52
Citation Pavlidis ET, Pavlidis TE. Molecular factors, diagnosis and management of gastrointestinal tract neuroendocrine tumors: An update. World J Clin Cases 2022; 10(27): 9573-9587
URL https://www.wjgnet.com/2307-8960/full/v10/i27/9573.htm
DOI https://dx.doi.org/10.12998/wjcc.v10.i27.9573
Full Article (PDF) WJCC-10-9573.pdf
Full Article (Word) WJCC-10-9573.docx
Manuscript File 78469_Auto_Edited-LM.docx
Answering Reviewers 78469-Answering reviewers.pdf
Audio Core Tip 78469-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 78469-Conflict-of-interest statement.pdf
Copyright License Agreement 78469-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 78469-Language certificate.pdf
Peer-review Report 78469-Peer-review(s).pdf
Scientific Misconduct Check 78469-Bing-Liu JH-2.jpg
Scientific Misconduct Check 78469-CrossCheck.jpg
Scientific Editor Work List 78469-Scientific editor work list.pdf