| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kang Nyeong Lee, Oh Young Lee, Hoon Jai Chun, Jin Il Kim, Sung Kook Kim, Sang Woo Lee, Kyung Sik Park, Kook Lae Lee, Suck Chei Choi, Jae-Young Jang, Gwang Ha Kim, In-kyung Sung, Moo In Park, Joong Goo Kwon, Nayoung Kim, Jae Jun Kim, Soo Teik Lee, Hyun Soo Kim, Ki Bae Kim, Yong Chan Lee, Myung-Gyu Choi, Joon Seong Lee, Hwoon-Yong Jung, Kwang Jae Lee, Jie-Hyun Kim and Hyunsoo Chung |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Oh Young Lee, MD, PhD, Professor, Department of Internal Medicine, Hanyang University College of Medicine, 222, Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea. leeoy@hanyang.ac.kr |
| Key Words |
Gastroesophageal reflux; Esophagitis; Proton pump inhibitors; Heartburn; Quality of life |
| Core Tip |
A mainstay therapy of erosive esophagitis (EE) is acid suppression using proton pump inhibitors (PPIs), which have shortcomings such as their slow absorption and variability in metabolism. Acid suppression can be competitively and reversibly achieved by a novel potassium-competitive acid blocker, fexuprazan. We compared the efficacy and safety of fexuprazan and esomeprazole (each 40 mg once daily) in patients with EE for 8 wk. We conclude that fexuprazan is a new alternative to PPIs, by showing that fexuprazan is not inferior to esomeprazole in endoscopic healing rate of EE at week 8 and in safety profiles. |
| Publish Date |
2022-11-25 02:19 |
| Citation |
Lee KN, Lee OY, Chun HJ, Kim JI, Kim SK, Lee SW, Park KS, Lee KL, Choi SC, Jang JY, Kim GH, Sung IK, Park MI, Kwon JG, Kim N, Kim JJ, Lee ST, Kim HS, Kim KB, Lee YC, Choi MG, Lee JS, Jung HY, Lee KJ, Kim JH, Chung H. Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis. World J Gastroenterol 2022; 28(44): 6294-6309 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i44/6294.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i44.6294 |
