| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Advances in neovascularization after diabetic ischemia
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yue Cai, Guang-Yao Zang, Yan Huang, Zhen Sun, Li-Li Zhang, Yong-Jiang Qian, Wei Yuan and Zhong-Qun Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
82070455 |
| the related Foundation of Jiangsu Province |
BK20201225 |
| the Medical Innovation Team Project of Jiangsu Province |
CXTDA2017010 |
| the Postgraduate Research＆Practice Innovation Program of Jiangsu Province |
KYCX20_3051, SJCX21_1729 |
|
| Corresponding Author |
Zhong-Qun Wang, PhD, Doctor, Professor, Researcher, Department of Cardiology, Affiliated Hospital of Jiangsu University, No. 438 Jiefang Road, Jingkou District, Zhenjiang 212000, Jiangsu Province, China. wangtsmc@126.com |
| Key Words |
Diabetes mellitus; Angiogenesis; Arteriogenesis; Ischemia; Hypoxia |
| Core Tip |
This review aimed to give an overview of neovascularization in patients with diabetes. First, we introduced the basic concepts and influencing factors of neovascularization, including angiogenesis and arteriogenesis. Second, the mechanisms regarding cytokines, classical and novel signaling pathways, glycolysis and lactic acid process and so on were described in detail. Then, the neovascularization after diabetic ischemia was further described in combination with the complications of diabetes, such as diabetic atherosclerosis, diabetic retinopathy, diabetic nephropathy and diabetic foot ulcer. Last but not least, the treatment plans were listed, with advantages and disadvantages, that may offer more treatment options. |
| Publish Date |
2022-11-11 10:05 |
| Citation |
Cai Y, Zang GY, Huang Y, Sun Z, Zhang LL, Qian YJ, Yuan W, Wang ZQ. Advances in neovascularization after diabetic ischemia. World J Diabetes 2022; 13(11): 926-939 |
| URL |
https://www.wjgnet.com/1948-9358/full/v13/i11/926.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v13.i11.926 |
