| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Best therapy for the easiest to treat hepatitis C virus genotype 1b-infected patients
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Dorota Zarębska-Michaluk, Michał Brzdęk, Jerzy Jaroszewicz, Magdalena Tudrujek-Zdunek, Beata Lorenc, Jakub Klapaczyński, Włodzimierz Mazur, Adam Kazek, Marek Sitko, Hanna Berak, Justyna Janocha-Litwin, Dorota Dybowska, Łukasz Supronowicz, Rafał Krygier, Jolanta Citko, Anna Piekarska and Robert Flisiak |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dorota Zarębska-Michaluk, PhD, Assistant Professor, Professor, Department of Infectious Diseases, Jan Kochanowski University, Radiowa 7, Kielce 25-317, Poland. dorota1010@tlen.pl |
| Key Words |
Hepatitis C; Genotype 1b; Direct-acting antivirals; Pangenotypic; Genotype-specific; Sustained virologic response |
| Core Tip |
Our real-world analysis focused on a population of patients chronically infected with the genotype 1b of hepatitis C virus. In the interferon era, this was considered to be difficult to treat due to low cure rates. Although we documented the very good effectiveness of all interferon-free regimens, we have shown that in what is now described as the easiest to treat population, the chance of response to antiviral treatment is reduced by coinfection with human immunodeficiency virus, while female sex, absence of decompensated cirrhosis and higher platelets count at baseline, increase the chances of a cure. |
| Publish Date |
2022-12-02 09:49 |
| Citation |
Zarębska-Michaluk D, Brzdęk M, Jaroszewicz J, Tudrujek-Zdunek M, Lorenc B, Klapaczyński J, Mazur W, Kazek A, Sitko M, Berak H, Janocha-Litwin J, Dybowska D, Supronowicz Ł, Krygier R, Citko J, Piekarska A, Flisiak R. Best therapy for the easiest to treat hepatitis C virus genotype 1b-infected patients. World J Gastroenterol 2022; 28(45): 6380-6396 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i45/6380.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i45.6380 |
