Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	7988
Country

Received	2013-12-11 08:34
Peer-Review Started	2013-12-11 13:17
To Make the First Decision	2014-01-08 14:39
Return for Revision	2014-01-09 11:23
Revised	2014-04-04 18:36
Second Decision	2014-05-29 16:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-29 17:02
Articles in Press	2014-05-29 17:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-07 17:25
Publish the Manuscript Online	2014-09-04 09:58

ISSN	2150-5330 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Pathophysiology of fistula formation in Crohn s disease
Manuscript Source	Invited Manuscript
All Author List	Michael Scharl and Gerhard Rogler
Funding Agency and Grant Number
Corresponding Author	Dr. Michael Scharl, MD, PhD, Division of Gastroenterology and Hepatology, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland. michael.scharl@usz.ch
Key Words	Crohn s disease; Fistula; Tumor necrosis factor; Interleukin-13; Transforming growth factor; Epithelial to mesenchymal transition
Core Tip	Fistulae represent an important complication in Crohn s disease (CD) patients. CD-associated fistulae originate from an epithelial defect due to destructive inflammation. Having undergone epithelial-to-mesenchymal transition (EMT), intestinal epithelial cells (IEC) penetrate into deeper layers of the gut wall causing further tissue damage finally forming connections to other organs or the body surface. EMT of IEC results in activation of matrix remodelling enzymes. Soluble mediators like TNF and IL-13 induce their own expression and expression of molecules associated with cell invasiveness. A better understanding of the pathophysiology of fistula formation is a prerequisite for developing more efficacious medical anti-fistula treatments.
Publish Date	2014-09-04 09:58
Citation	Scharl M, Rogler G. Pathophysiology of fistula formation in Crohn s disease. World J Gastrointest Pathophysiol 2014; 5(3): 205-212
URL	http://www.wjgnet.com/2150-5330/full/v5/i3/205.htm
DOI	http://dx.doi.org/10.4291/wjgp.v5.i3.205

Full Article (PDF)	WJGP-5-205.pdf
Full Article (Word)	WJGP-5-205.doc
Manuscript File	7988-Review.doc
Answering Reviewers	7988-Answering reviewers.pdf
Copyright License Agreement	7988-Copyright assignment.pdf
Peer-review Report	7988-Peer review(s).pdf
Scientific Misconduct Check	7988-CrossCheck.jpg
Scientific Editor Work List	7988-Scientific editor work list.pdf