Publication Name	World Journal of Gastroenterology
Manuscript ID	80210
Country	Australia

Received	2022-09-20 04:15
Peer-Review Started	2022-09-20 04:19
To Make the First Decision
Return for Revision	2022-11-15 07:32
Revised	2022-12-19 04:40
Second Decision	2023-01-10 03:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-01-10 18:35
Articles in Press	2023-01-10 18:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-01-12 08:30
Publish the Manuscript Online	2023-01-20 13:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Gaseous metabolites as therapeutic targets in ulcerative colitis
Manuscript Source	Invited Manuscript
All Author List	Chu K Yao and Chen Sarbagili-Shabat
ORCID	Author(s) ORCID Number Chu K Yao http://orcid.org/0000-0002-5301-2457
Funding Agency and Grant Number
Corresponding Author	Chu K Yao, PhD, RN, Senior Research Fellow, Department of Gastroenterology, Monash University, Level 6, Alfred Centre, 99 Commercial Road, Melbourne 3004, Australia. chu.yao@monash.edu
Key Words	Diet; Ulcerative colitis; Hydrogen sulfide; Nitric oxide; Sulphide-reducing diet
Core Tip	There is room to develop efficacious dietary therapies in ulcerative colitis (UC) by targeting underlying pathogenic mechanisms. Emerging data indicates that dietary factors play a significant role in modulating two gaseous metabolites, hydrogen sulphide and nitric oxide, that affect the integrity of the colonic mucosal barrier in UC. These gases are produced by the colonic microbiota in response to sulphur-containing protein and to a lesser extent, inorganic sulphur (sulphates and sulphites), but suppressed by the presence of fermentable fibre. Preliminary work suggests that a multi-prong diet that targets reduction of these gases have therapeutic potential and further randomised-controlled trials are underway.
Publish Date	2023-01-20 13:48
Citation	Yao CK, Sarbagili-Shabat C. Gaseous metabolites as therapeutic targets in ulcerative colitis. World J Gastroenterol 2023; 29(4): 682-691
URL	https://www.wjgnet.com/1007-9327/full/v29/i4/682.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i4.682

Full Article (PDF)	WJG-29-682.pdf
Full Article (Word)	WJG-29-682.docx
Manuscript File	80210_Auto_Edited-LM.docx
Answering Reviewers	80210-Answering reviewers.pdf
Audio Core Tip	80210-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	80210-Conflict-of-interest statement.pdf
Copyright License Agreement	80210-Copyright license agreement.pdf
Peer-review Report	80210-Peer-review(s).pdf
Scientific Misconduct Check	80210-Bing-Wang JJ-2.png
Scientific Editor Work List	80210-Scientific editor work list.pdf