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1/10/2023 8:49:38 AM | Browse: 187 | Download: 691
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 80245
Country/Territory China
Received
2022-09-20 16:03
Peer-Review Started
2022-09-20 16:06
To Make the First Decision
Return for Revision
2022-10-14 22:14
Revised
2022-10-28 21:52
Second Decision
2022-12-07 03:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-12-07 18:03
Articles in Press
2022-12-07 18:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-12-13 04:19
Publish the Manuscript Online
2023-01-10 08:49
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Challenges and exploration for immunotherapies targeting cold colorectal cancer
Manuscript Source Invited Manuscript
All Author List Dan-Dan Li, Yuan-Ling Tang and Xin Wang
ORCID
Author(s) ORCID Number
Dan-Dan Li http://orcid.org/0000-0001-7419-4686
Yuan-Ling Tang http://orcid.org/0000-0002-1151-5806
Xin Wang http://orcid.org/0000-0003-3599-6904
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China No. 82073338
Sichuan Science and Technology Support Project No. 2021YFSY0039,No. 22ZDYF0499
The 1·3·5 Project for Disciplines of Excellence–Clinical Research Incubation Project West China Hospital, Sichuan University No. 2020HXFH002
The 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University No. ZYJC21059
Corresponding Author Xin Wang, MD, PhD, Professor, Department of Abdominal Oncology/Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, No. 37 Wainan Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan Province, China. wangxin213@sina.com
Key Words Colorectal cancer; Immune checkpoint inhibitors; Cold tumors; Immunotherapy mechanism; Combination therapy; Effector T cells
Core Tip This review focuses on the potential mechanism of immunotherapy ineffectiveness in colorectal cancer patients with “cold tumors”, how to increase the infiltration of effector T cells at tumor sites by combination therapy strategies, how to transform “cold tumors” into “hot tumors” to expand the number of people benefiting from immunotherapy, and make recommendations on how to screen out immune-dominant populations in the future.
Publish Date 2023-01-10 08:49
Citation Li DD, Tang YL, Wang X. Challenges and exploration for immunotherapies targeting cold colorectal cancer. World J Gastrointest Oncol 2023; 15(1): 55-68
URL https://www.wjgnet.com/1948-5204/full/v15/i1/55.htm
DOI https://dx.doi.org/10.4251/wjgo.v15.i1.55
Full Article (PDF) WJGO-15-55.pdf
Full Article (Word) WJGO-15-55.docx
Manuscript File 80245_Auto_Edited-LM.docx
Answering Reviewers 80245-Answering reviewers.pdf
Audio Core Tip 80245-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 80245-Conflict-of-interest statement.pdf
Copyright License Agreement 80245-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 80245-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 80245-Language certificate.pdf
Peer-review Report 80245-Peer-review(s).pdf
Scientific Misconduct Check 80245-Bing-Chen YL-2.png
Scientific Editor Work List 80245-Scientific editor work list.pdf