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8/29/2014 11:57:00 AM | Browse: 281 | Download: 274
Publication Name World Journal of Gastroenterology
Manuscript ID 8029
Country of Manuscript Source China
Received
2013-12-12 16:11
Peer-Review Started
2013-12-12 18:19
To Make the First Decision
2014-01-15 13:30
Return for Revision
2014-01-20 18:39
Revised
2014-02-24 08:26
Second Decision
2014-05-26 16:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-05-26 16:44
Articles in Press
2014-05-26 17:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-06-09 18:51
Typeset the Manuscript
2014-08-15 17:46
Publish the Manuscript Online
2014-08-29 11:57
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Retrospective Study
Article Title Decreased expression of miR-133a correlates with poor prognosis in colorectal cancer patients
Manuscript Source Unsolicited Manuscript
All Author List Li-Li Wang, Lu-Tao Du, Juan Li, Yi-Min Liu, Ai-Lin Qu, Yong-Mei Yang, Xin Zhang, Gui-Xi Zheng and Chuan-Xin Wang
Funding Agency and Grant Number
Funding Agency Grant Number
National Key Clinical Medical Specialties Foundation and the National Natural Science Foundation of China 81271916
National Key Clinical Medical Specialties Foundation and the National Natural Science Foundation of China 81301506
Correspondence To Correspondence to: Chuan-Xin Wang, MD, PhD, Department of Clinical Laboratory, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, Shandong Province, China. cxwang@sdu.edu.cn
Keywords Colorectal cancer; Biomarker; MicroRNA-133a; Prognosis; Real-time polymerase chain reaction
Core Tip In the present study, the level of microRNA-133a (miR-133a) was found to be downregulated in colorectal cancer (CRC) tissues. The altered expression of miR-133a was significantly associated with malignant behavior, including tumor cell differentiation, local invasion, lymph node metastasis and tumor-node-metastasis stage. Multivariate analysis suggested that low expression of miR-133a is an independent prognostic factor for CRC. Furthermore, the data suggest that miR-133a may play a critical role in CRC progression, and thus may serve as a potential therapeutic target.
Publish Date 2014-08-29 11:57
Citation Wang LL, Du LT, Li J, Liu YM, Qu AL, Yang YM, Zhang X, Zheng GX, Wang CX. Decreased expression of miR-133a correlates with poor prognosis in colorectal cancer patients. World J Gastroenterol 2014; 20(32): 11340-11346
Url http://www.wjgnet.com/1007-9327/full/v20/i32/11340.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i32.11340
Full Article (PDF) WJG-20-11340.pdf
Full Article (Word) WJG-20-11340.doc
Manuscript File 8029-Review.doc
Answering Reviewers 8029-Answering reviewers.pdf
Copyright License Agreement 8029-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate AMEpc3080_locked for submission_with figures.doc
Peer-review Report 8029-Peer review(s).pdf
Scientific Misconduct Check 8029-CrossCheck.jpg
Scientific Editor Work List 8029-Scientific editor work list.pdf