| Category |
Biotechnology & Applied Microbiology |
| Manuscript Type |
Review |
| Article Title |
Value of a newly sequenced bacterial genome
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Eudes GV Barbosa, Flavia F Aburjaile, Rommel TJ Ramos, Adriana R Carneiro, Yves Le Loir, Jan Baumbach, Anderson Miyoshi, Artur Silva and Vasco Azevedo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) in Brazil, processes BEX |
12954-12-8 (to Barbosa EGV) |
| Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) in Brazil, processes BEX |
31270-901 (to Aburjaile FF) |
|
| Corresponding Author |
Vasco Azevedo, MD, PhD, Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Univeridade Federal de Minas Gerais, Av. Antonio Carlos 6627 Pampulha, Belo Horizonte 31270-901, Brazil. vasco@icb.ufmg.br |
| Key Words |
Next-generation sequencing; Drafts; Prokaryotic genomes; Computational tools; Omics |
| Core Tip |
Next-generation sequencing (NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of bacterial genomes has not only brought excitement to the field of genomics, it has also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has consequences for genome quality, resulting in an exponential increase in draft genome deposits in public databases. This review will address the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology, as well as the impact of NGS on draft bacterial genomes. |
| Publish Date |
2014-06-11 10:30 |
| Citation |
Barbosa EGV, Aburjaile FF, Ramos RTJ, Carneiro AR, Le Loir Y, Baumbach J, Miyoshi A, Silva A, Azevedo V. value of a newly sequenced bacterial genome. World J Biol Chem 2014; 5(2): 161-168 |
| URL |
http://www.wjgnet.com/1949-8454/full/v5/i2/161.htm |
| DOI |
http://dx.doi.org/10.4331/wjbc.v5.i2.161 |
