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Articles Published Processes
1/20/2023 1:48:21 PM | Browse: 26 | Download: 60
Publication Name World Journal of Gastroenterology
Manuscript ID 80548
Country/Territory Greece
Received
2022-10-02 12:02
Peer-Review Started
2022-10-02 12:05
To Make the First Decision
Return for Revision
2022-10-29 00:20
Revised
2022-11-03 12:56
Second Decision
2022-12-30 03:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-12-31 05:58
Articles in Press
2022-12-31 05:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
2023-01-08 00:43
Typeset the Manuscript
2023-01-12 08:32
Publish the Manuscript Online
2023-01-20 13:48
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Iron as a therapeutic target in chronic liver disease
Manuscript Source Invited Manuscript
All Author List Elias Kouroumalis, Ioannis Tsomidis and Argyro Voumvouraki
ORCID
Author(s) ORCID Number
Elias Kouroumalis http://orcid.org/0000-0002-6875-906X
Ioannis Tsomidis http://orcid.org/0000-0002-8595-2750
Argyro Voumvouraki http://orcid.org/0000-0002-2725-6028
Funding Agency and Grant Number
Corresponding Author Elias Kouroumalis, MD, PhD, Emeritus Professor, Liver Research Laboratory, University of Crete Medical School, 13 Kalokerinou Street, Voutes, Heraklion 71003, Greece. kouroumi@uoc.gr
Key Words Iron overload; Liver diseases; Ferroptosis; Ferritinophagy; Ferroptosis modulators
Core Tip Iron overload may damage the liver in a variety of liver diseases such as cirrhosis and hepatocellular carcinoma affecting patient survival. In this review, we presented the evidence, both experimental and clinical, of the detrimental effects of iron deposition in hepatocytes and other liver sinusoidal cells. Moreover, we examined the mechanism and implications of the recently described ferroptosis in the evolution of liver diseases. Ferroptosis, is a form of regulated hepatocyte death caused by excess iron and lipid peroxidation. Inhibition or induction of ferroptosis may profoundly improve the natural course of many liver diseases as demonstrated by a large number of experimental studies and few clinical data.
Publish Date 2023-01-20 13:48
Citation Kouroumalis E, Tsomidis I, Voumvouraki A. Iron as a therapeutic target in chronic liver disease. World J Gastroenterol 2023; 29(4): 616-655
URL https://www.wjgnet.com/1007-9327/full/v29/i4/616.htm
DOI https://dx.doi.org/10.3748/wjg.v29.i4.616
Full Article (PDF) WJG-29-616.pdf
Full Article (Word) WJG-29-616.docx
Manuscript File 80548-Review-FilipodiaCL.docx
Answering Reviewers 80548-Answering reviewers.pdf
Audio Core Tip 80548-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 80548-Conflict-of-interest statement.pdf
Copyright License Agreement 80548-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 80548-Language certificate.pdf
Peer-review Report 80548-Peer-review(s).pdf
Scientific Misconduct Check 80548-Bing-Wang JJ-2.png
Scientific Editor Work List 80548-Scientific editor work list.pdf