| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Down-regulation of FoxM1 inhibits viability and invasion of gallbladder carcinoma cells, partially dependent on inducement of cellular senescence
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Tao, Xin-Sen Xu, Yan-Zhou Song, Kai Qu, Qi-Fei Wu, Rui-Tao Wang, Fan-Di Meng, Ji-Chao Wei, Shun-Bin Dong, Yue-Lang Zhang, Min-Hui Tai, Ya-Feng Dong, Lin Wang and Chang Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science Foundation of the First Affiliated Hospital of Medical College, Xi’an Jiaotong University |
2010YK1 |
|
| Corresponding Author |
Chang Liu, MD, PhD, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com |
| Key Words |
Forkhead box M1; Gallbladder carcinoma; Senescence; Viability; Invasion |
| Core Tip |
Gallbladder cancer is characterized by early metastases, thus it is in urgent need to identify novel therapies to enhance the therapeutic effect. We have previously reported that Forkhead box M1 (FoxM1) expression was closely correlated with gallbladder carcinoma differentiation, Nevin stage and metastasis, indicating the potential roles of FoxM1 in gallbladder carcinoma. In this study, by regulating the expression of FoxM1 with small interfering RNAs, we demonstrated the impact of FoxM1 on cellular viability in a human gallbladder carcinoma cell line, which was probably via the regulation of cellular senescence, revealing FoxM1 as a potential target for gallbladder carcinoma therapy. |
| Publish Date |
2014-07-26 13:36 |
| Citation |
Tao J, Xu XS, Song YZ, Qu K, Wu QF, Wang RT, Meng FD, Wei JC, Dong SB, Zhang YL, Tai MH, Dong YF, Wang L, Liu C. Down-regulation of FoxM1 inhibits viability and invasion of gallbladder carcinoma cells, partially dependent on inducement of cellular senescence. World J Gastroenterol 2014; 20(28): 9497-9505 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i28/9497.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i28.9497 |
