BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/7/2014 1:30:00 PM | Browse: 1036 | Download: 956
Publication Name World Journal of Gastroenterology
Manuscript ID 8248
Country/Territory United States
Received
2013-12-22 13:28
Peer-Review Started
2013-12-23 09:01
To Make the First Decision
2014-02-28 18:04
Return for Revision
2014-03-07 20:23
Revised
2014-03-21 04:49
Second Decision
2014-06-05 10:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-06-05 10:58
Articles in Press
2014-06-05 11:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-08-24 20:48
Publish the Manuscript Online
2014-09-07 13:31
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Advances in the management of peritoneal mesothelioma
Manuscript Source Invited Manuscript
All Author List Ali Raza, Wei-Ching Huang and Kazuaki Takabe
Funding Agency and Grant Number
Funding Agency Grant Number
United States National Institute of Health R01CA160688
Susan G Komen Investigator Initiated Research Grant IIR12222224 (to Kazuaki Takabe)
Corresponding Author Kazuaki Takabe, MD, PhD, FACS, Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine and Massey Cancer Center, PO Box 980011, West Hospital 7-402, 1200 East Broad Street, Richmond, VA 23298-0011, United States. ktakabe@vcu.edu
Key Words Peritoneal mesothelioma; Mesothelioma; Hyperthermic intraperitoneal chemotherapy; Cytoreduction; Sphingosine kinase; Sphingosine-1-phosphate; FTY720
Core Tip Peritoneal mesothelioma (PM) historically has been associated with a very poor prognosis. Cytoreduction with hyperthermic intraperitoneal chemotherapy improved survival outcomes but carries significant morbidity. Increasingly, research has focused on identifying molecular targets and only a handful have been described; even fewer directed therapies have been evaluated. We review the role of sphingosine kinase 1 and sphingosine-1-phosphate (S1P) signaling in PM and discuss the possibility of targeting it with FTY720, a functional antagonist of S1P Receptor 1. Further investigation is warranted in this new avenue of interest.
Publish Date 2014-09-07 13:31
Citation Raza A, Huang WC, Takabe K. Advances in the management of peritoneal mesothelioma. World J Gastroenterol 2014; 20(33): 11700-11712
URL http://www.wjgnet.com/1007-9327/full/v20/i33/11700.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i33.11700
Full Article (PDF) WJG-20-11700.pdf
Full Article (Word) WJG-20-11700.doc
Manuscript File 8248-Review.doc
Answering Reviewers 8248-Answering reviewers.pdf
Copyright License Agreement 8248-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 8248-Language certificate.pdf
Peer-review Report 8248-Peer review(s).pdf
Scientific Misconduct Check 8248-CrossCheck.jpg
Scientific Editor Work List 8248-Scientific editor work list.pdf