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9/15/2023 10:15:19 AM | Browse: 125 | Download: 162
Publication Name World Journal of Psychiatry
Manuscript ID 85398
Country China
Received
2023-05-24 01:02
Peer-Review Started
2023-05-24 01:03
To Make the First Decision
Return for Revision
2023-06-12 02:36
Revised
2023-06-20 03:18
Second Decision
2023-07-14 02:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-07-14 09:52
Articles in Press
2023-07-14 09:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-09-08 07:43
Publish the Manuscript Online
2023-09-15 10:15
ISSN 2220-3206 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Clinical Neurology
Manuscript Type Basic Study
Article Title Exosomal miR-320e through wnt2targeted inhibition of the Wnt/β-catenin pathway allevisate cerebral small vessel disease and cognitive impairment
Manuscript Source Unsolicited Manuscript
All Author List Zheng Wang, Xue-Ning Li, Shao-Nan Yang, Yuan Wang, Ke-Jin Gao, Bin Han and Ai-Jun Ma
ORCID
Author(s) ORCID Number
Zheng Wang http://orcid.org/0000-0003-1675-7334
Ai-Jun Ma http://orcid.org/0009-0002-7624-0572
Funding Agency and Grant Number
Corresponding Author Ai-Jun Ma, MD, Attending Doctor, Department of Neurology, The Affiliated Hospital of Qingdao University, No.16, Jiangsu Street, Qingdao 266001, Shandong Province, China. drmaj@qdu.edu.cn
Key Words Exosome; Cerebral small vessel disease; miRNA-320e; Wnt2; Wnt/β-catenin pathway; Depressed
Core Tip Exosomal miR-320e is downregulated in patients with cerebral small vessel disease (CVSD), and it inhibits the Wnt/β-catenin pathway by targeting Wnt2 in response to oxidative stress. Uptake of exosomes carrying miR-320e can also target Wnt2 and inhibit the Wnt2/β-catenin pathway. Elevated miR-320e expression may protect patients with CVSD from severe cognitive impairment and depression, as it correlates positively with MoCA/EFA and HAMD/BDI scores. Therefore, exosomal miR-320e may play a protective role in CVSD progression by suppressing the Wnt/β-catenin pathway, indicating its potential as a therapeutic target for CVSD.
Publish Date 2023-09-15 10:15
Citation Wang Z, Li XN, Yang SN, Wang Y, Gao KJ, Han B, Ma AJ. Exosomal miR-320e through wnt2targeted inhibition of the Wnt/β-catenin pathway allevisate cerebral small vessel disease and cognitive impairment. World J Psychiatry 2023; 13(9): 630-644
URL https://www.wjgnet.com/2220-3206/full/v13/i9/630.htm
DOI https://dx.doi.org/10.5498/wjp.v13.i9.630
Full Article (PDF) WJP-13-630-with-cover.pdf
Full Article (Word) WJP-13-630.docx
Manuscript File 85398_Auto_Edited-JLW.doc
Answering Reviewers 85398-Answering reviewers.pdf
Audio Core Tip 85398-Audio core tip.mp3
Biostatistics Review Certificate 85398-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 85398-Conflict-of-interest statement.pdf
Copyright License Agreement 85398-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 85398-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 85398-Language certificate.pdf
Supplementary Material 85398-Supplementary material.pdf
Peer-review Report 85398-Peer-review(s).pdf
Scientific Misconduct Check 85398-Bing-Li L-2.png
Scientific Editor Work List 85398-Scientific editor work list.pdf
CrossCheck Report 85398-CrossCheck report.pdf
CrossCheck Report 85398-CrossCheck.png