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Articles Published Processes
9/25/2023 2:36:45 AM | Browse: 208 | Download: 564
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Received |
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2023-07-27 03:04 |
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Peer-Review Started |
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2023-07-27 03:04 |
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To Make the First Decision |
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Return for Revision |
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2023-08-03 22:36 |
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Revised |
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2023-08-16 09:58 |
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Second Decision |
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2023-09-12 02:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-09-12 20:29 |
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Articles in Press |
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2023-09-12 20:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-09-18 10:47 |
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Publish the Manuscript Online |
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2023-09-25 02:36 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Mechanism of adipose-derived mesenchymal stem cell exosomes in the treatment of heart failure
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lei Wang, Jin-Jin Zhang, Sha-Sha Wang and Liang Li |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Liang Li, MM, Doctor, Doctor, Department of Geriatric Medicine, Fourth Medical Center of PLA General Hospital, No. 51 Fucheng road, Haidian District, Beijing 100048, China. liliangcc@163.com |
| Key Words |
Adipose-derived mesenchymal stem cell exosomes; Heart failure; Cardiomyocyte apoptosis |
| Core Tip |
Our study highlights the potential of mesenchymal stem cell exosomes (Exos) from adipose tissue as a promising therapy for heart failure (HF). Administration of adipose-derived mesenchymal stem cell Exos improved cardiac function, evidenced by increased ATP content and enhanced parameters like ejection fraction, fractional shortening, and stroke volume. Furthermore, adipose-derived stem cells (ADSCs)-Exo reduced serum levels of b-type natriuretic peptide and atrial natriuretic peptide, associated with HF progression, and exhibited anti-apoptotic effects by regulating pro- and anti-apoptotic proteins in cardiac tissue. These findings suggest that ADSCs-Exo could prevent cardiomyocyte death and inhibit HF progression. |
| Publish Date |
2023-09-25 02:36 |
| Citation |
Wang L, Zhang JJ, Wang SS, Li L. Mechanism of adipose-derived mesenchymal stem cell exosomes in the treatment of heart failure. World J Stem Cells 2023; 15(9): 897-907 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i9/897.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i9.897 |
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