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9/25/2023 2:36:45 AM | Browse: 85 | Download: 152
Publication Name World Journal of Stem Cells
Manuscript ID 85452
Country China
Received
2023-07-27 03:04
Peer-Review Started
2023-07-27 03:04
To Make the First Decision
Return for Revision
2023-08-03 22:36
Revised
2023-08-16 09:58
Second Decision
2023-09-12 02:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-09-12 20:29
Articles in Press
2023-09-12 20:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-09-18 10:47
Publish the Manuscript Online
2023-09-25 02:36
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Basic Study
Article Title Mechanism of adipose-derived mesenchymal stem cell exosomes in the treatment of heart failure
Manuscript Source Unsolicited Manuscript
All Author List Lei Wang, Jin-Jin Zhang, Sha-Sha Wang and Liang Li
ORCID
Author(s) ORCID Number
Liang Li http://orcid.org/0000-0001-9652-9782
Funding Agency and Grant Number
Corresponding Author Liang Li, MM, Doctor, Department of Geriatric Medicine, Fourth Medical Center of PLA General Hospital, No. 51 Fucheng road, Haidian District, Beijing 100048, China. liliangcc@163.com
Key Words Adipose-derived mesenchymal stem cell exosomes; Heart failure; Cardiomyocyte apoptosis
Core Tip Our study highlights the potential of mesenchymal stem cell exosomes (Exos) from adipose tissue as a promising therapy for heart failure (HF). Administration of adipose-derived mesenchymal stem cell Exos improved cardiac function, evidenced by increased ATP content and enhanced parameters like ejection fraction, fractional shortening, and stroke volume. Furthermore, adipose-derived stem cells (ADSCs)-Exo reduced serum levels of b-type natriuretic peptide and atrial natriuretic peptide, associated with HF progression, and exhibited anti-apoptotic effects by regulating pro- and anti-apoptotic proteins in cardiac tissue. These findings suggest that ADSCs-Exo could prevent cardiomyocyte death and inhibit HF progression.
Publish Date 2023-09-25 02:36
Citation Wang L, Zhang JJ, Wang SS, Li L. Mechanism of adipose-derived mesenchymal stem cell exosomes in the treatment of heart failure. World J Stem Cells 2023; 15(9): 897-907
URL https://www.wjgnet.com/1948-0210/full/v15/i9/897.htm
DOI https://dx.doi.org/10.4252/wjsc.v15.i9.897
Full Article (PDF) WJSC-15-897-with-cover.pdf
Full Article (Word) WJSC-15-897.docx
The ARRIVE Guidelines 85452-The ARRIVE guidelines.pdf
Manuscript File 85452_Auto_Edited-LM.docx
Answering Reviewers 85452-Answering reviewers.pdf
Audio Core Tip 85452-Audio core tip.mp3
Biostatistics Review Certificate 85452-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 85452-Conflict-of-interest statement.pdf
Copyright License Agreement 85452-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 85452-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 85452-Language certificate.pdf
Peer-review Report 85452-Peer-review(s).pdf
Scientific Misconduct Check 85452-Bing-Wang JJ-2.png
Scientific Editor Work List 85452-Scientific editor work list.pdf