| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Diabetes exacerbates inflammatory bowel disease in mice with diet-induced obesity
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kendra L Francis, Kimberly M Alonge, Maria Cristina Pacheco, Shannon J Hu, Cody A Krutzsch, Gregory J Morton, Michael W Schwartz and Jarrad M Scarlett |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The National Institutes of Health under the National Institute of Diabetes and Digestive and Kidney Diseases (NIH-NIDDK) |
DK114474 |
| The National Institutes of Health under the National Institute of Diabetes and Digestive and Kidney Diseases (NIH-NIDDK) |
DK128383 |
| The National Institutes of Health under the National Institute of Diabetes and Digestive and Kidney Diseases (NIH-NIDDK) |
DK131695 |
| The National Institutes of Health under the National Institute of Diabetes and Digestive and Kidney Diseases (NIH-NIDDK) |
DK101997 |
| The National Institutes of Health under the National Institute of Diabetes and Digestive and Kidney Diseases (NIH-NIDDK) |
DK083042 |
| The National Institutes of Health under the National Institute of Diabetes and Digestive and Kidney Diseases (NIH-NIDDK) |
DK089056 |
| The National Institutes of Health under the National Institute of Diabetes and Digestive and Kidney Diseases (NIH-NIDDK) |
DK124238 |
| Department of Defense (JMS) |
W81XWH2110635 |
| The University of Washington Royalty Research Fund (JMS) |
A139339 |
| The NIH-NIDDK T32 Training Grant (KLF) |
DK007742 |
| The NIH-National Heart, Lung, and Blood Institute T32 Training Grant (KMA) |
HL007028 |
| The NIH-NIDDK–funded Diabetes Research Center |
P30DK017047 |
| The Nutrition Obesity Research Center at the University of Washington |
P30DK035816 |
|
| Corresponding Author |
Jarrad M Scarlett, MD, PhD, Assistant Professor, Department of Pediatric Gastroenterology and Hepatology, Seattle Children’s Hospital, 750 East Republican Street F770, Seattle, WA 98105, United States. jarrad.scarlett@seattlechildrens.org |
| Key Words |
Tight junction proteins; Colitis in mice; Hyperglycemia; Intestinal barrier; Obesity; Type 2 diabetes; Inflammatory bowel disease |
| Core Tip |
Metabolic syndrome affects many patients with inflammatory bowel disease (IBD). This study used mouse models of colitis to investigate how diabetes and obesity interact to impair intestinal barrier function and exacerbate IBD outcomes, highlighting the deleterious impact of sustained hyperglycemia on intestinal barrier integrity. We showed that diabetic hyperglycemia impairs the colonic mucin barrier and tight junction protein abundance in the setting of diet-induced obesity, which corresponds to worse clinical and histopathological IBD outcomes. These findings are important because as more patients with IBD are affected by obesity and/or diabetes, it is imperative to understand how these disease processes interact. |
| Publish Date |
2023-09-01 08:11 |
| Citation |
Francis KL, Alonge KM, Pacheco MC, Hu SJ, Krutzsch CA, Morton GJ, Schwartz MW, Scarlett JM. Diabetes exacerbates inflammatory bowel disease in mice with diet-induced obesity. World J Gastroenterol 2023; 29(33): 4991-5004 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i33/4991.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i33.4991 |
