| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Osteopontin knockdown suppresses the growth and angiogenesis of colon cancer cells
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Xin-Lin Wu, Kai-Jin Lin, Ai-Ping Bai, Wan-Xiang Wang, Xing-Kai Meng, Xiu-Lan Su, Ming-Xing Hou, Pei-De Dong, Jun-Jing Zhang, Zhao-Yang Wang and Lin Shi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81260364 |
| National Natural Science Foundation of China |
81270472 |
| National Natural Science Foundation of China |
81070310 |
| “Chunhui” Program of Ministry of Education in China |
Z2012007 |
| Natural Science Foundation of Inner Mongolian Autonomous Region |
2012MS1123 |
| Natural Science Foundation of Inner Mongolian Autonomous Region |
2013MS1132 |
|
| Corresponding Author |
Lin Shi, MD, Department of Pathology, the Affiliated Hospital of Inner Mongolia Medical University, 1 Tongdao North Street, Inner Mongolian Autonomous Region, Huhhot 010059, Inner Mongolian Autonomous Region, China. shilinsd2003@aliyun.com |
| Key Words |
Colon carcinoma; Lovo cells; Osteopontin; Angiogenesis; RNA interference |
| Core Tip |
This study investigated the anti-tumor effects of osteopontin (OPN) knockdown in human colon cancer (Lovo) cells. Despite recent evidence that shows OPN expression is closely related to the development of colorectal cancer, the mechanism remains elusive. The results of the present study showed that siRNA-mediated downregulation of OPN inhibited the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, MMP-9 and urokinase plasminogen activator in Lovo cells, which may lead to decreased invasion and angiogenesis of colon cancer. |
| Publish Date |
2014-08-18 16:49 |
| Citation |
Wu XL, Lin KJ, Bai AP, Wang WX, Meng XK, Su XL, Hou MX, Dong PD, Zhang JJ, Wang ZY, Shi L. Osteopontin knockdown suppresses the growth and angiogenesis of colon cancer cells. World J Gastroenterol 2014; 20(30): 10440-10448 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i30/10440.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i30.10440 |
