Publication Name	World Journal of Orthopedics
Manuscript ID	88347
Country	China

Received	2023-09-21 05:40
Peer-Review Started	2023-09-21 05:42
To Make the First Decision
Return for Revision	2023-11-29 06:57
Revised	2023-12-01 08:06
Second Decision	2024-01-11 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-01-11 07:06
Articles in Press	2024-01-11 07:06
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-01-10 02:15
Typeset the Manuscript	2024-01-23 00:21
Publish the Manuscript Online	2024-02-07 02:35

ISSN	2218-5836 (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Editorial
Article Title	Mitochondrial dysfunction in type 2 diabetes: A neglected path to skeletal muscle atrophy
Manuscript Source	Invited Manuscript
All Author List	Jian-Jun Wu, Hui-Min Xian, Da-Wei Yang and Fan Yang
ORCID	Author(s) ORCID Number Da-Wei Yang http://orcid.org/0000-0002-7217-9383 Fan Yang http://orcid.org/0000-0003-4676-3778
Funding Agency and Grant Number	Funding Agency Grant Number the Foundation of State Key Laboratory of Component-based Chinese Medicine CBCM2023107 National Natural Science Foundation of China 81901853 Specially Funded Scientific Research Project of the Fourth Affiliated Hospital of Harbin Medical University HYDSYTB202126
Corresponding Author	Fan Yang, MD, MMed, PhD, Associate Research Scientist, Occupational Physician, Postdoc, Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Nangang District, Harbin 150001, Heilongjiang Province, China. yangfana@sina.com
Key Words	Mfn-2; Oxidative stress; Mitochondria metabolism; Skeletal muscle atrophy; Diabetes
Core Tip	Type 2 diabetes mellitus (T2DM) poses a substantial global health challenge. Attaining optimal glycemic control is crucial for mitigating complications and mortality associated with T2DM. However, recent research has unveiled a frequently overlooked complication: The progressive atrophy of skeletal muscle. Mitochondria, pivotal for cellular energy production, uphold a delicate equilibrium in their fusion and fission processes. Investigating the interplay between mitochondrial dysfunction and skeletal muscle atrophy in T2DM is imperative for advancing our comprehension of diabetes. Findings from cellular and animal models suggest that targeting mitochondrial dynamics, particularly through the modulation of Mfn-2, holds promise as a therapeutic strategy to counteract muscle atrophy induced by diabetes. This approach underscores a novel intersection in the management of diabetic complications, forging a connection between metabolic control and muscular health.
Publish Date	2024-02-07 02:35
Citation	Wu JJ, Xian HM, Yang DW, Yang F. Mitochondrial dysfunction in type 2 diabetes: A neglected path to skeletal muscle atrophy. World J Orthop 2024; 15(2): 101-104
URL	https://www.wjgnet.com/2218-5836/full/v15/i2/101.htm
DOI	https://dx.doi.org/10.5312/wjo.v15.i2.101

Full Article (PDF)	WJO-15-101-with-cover.pdf
Full Article (Word)	WJO-15-101.docx
Manuscript File	88347_Auto_Edited-CL-WangTQ-YJP.docx
Answering Reviewers	88347-Answering reviewers.pdf
Audio Core Tip	88347-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	88347-Conflict-of-interest statement.pdf
Copyright License Agreement	88347-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	88347-Grant application form(s).PDF
Non-Native Speakers of English Editing Certificate	88347-Language certificate.pdf
Peer-review Report	88347-Peer-review(s).pdf
Scientific Misconduct Check	88347-Bing-Lin C-2.png
Scientific Editor Work List	88347-Scientific editor work list.pdf
CrossCheck Report	88347-CrossCheck.png
CrossCheck Report	88347-CrossCheck report.pdf