Publication Name	World Journal of Diabetes
Manuscript ID	9129
Country	United Kingdom

Received	2014-02-18 17:28
Peer-Review Started	2014-02-20 21:21
To Make the First Decision	2014-03-26 15:28
Return for Revision	2014-04-02 20:37
Revised	2014-04-23 15:23
Second Decision	2014-05-29 08:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-29 09:42
Articles in Press	2014-05-29 11:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-05 18:40
Publish the Manuscript Online	2014-08-17 13:16

ISSN	1948-9358 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Molecular mechanisms of protein induced hyperinsulinaemic hypoglycaemia
Manuscript Source	Invited Manuscript
All Author List	Suresh Chandran, Fabian Yap and Khalid Hussain
Funding Agency and Grant Number
Corresponding Author	Dr. Khalid Hussain, Reader/Honorary Consultant Paediatric Endocrinologist, Developmental Endocrinology Research Group, Molecular Genetics Unit, Institute of Child Health, University College London, 30 Guildford Street, London WC1N 1EH, United Kingdom. khalid.hussain@ucl.ac.uk
Key Words	Hyperinsulinaemic hypoglycaemia; KATP ch?annel; Glutamate dehydrogenase; Hyperinsulinism/Hyperammonaemia syndrome; Short-chain-3-hydroxyacyl-CoA dehydrogenase; Glutamine
Core Tip	The interplay between glucose, amino acid and fatty acid metabolism is critical for regulated insulin secretion. Mitochondrial metabolism of glucose, amino acid and fatty acids generates metabolic coupling factors (such as ATP, NADPH, glutamate, long chain acyl-CoA and diacylglycerol) which trigger insulin secretion. The observation of protein induced hypoglycaemia in patients with mutations in GLUD1 [encoding for the enzyme glutamate dehydrogenase (GDH)] and HADH genes, has provided novel mechanistic insights into the regulation of insulin secretion by amino acid and fatty acid metabolism. Metabolic signals arising from amino acid and fatty acid metabolism converge on the enzyme GDH which integrates both signals from both pathways and controls insulin secretion. Hence GDH seems to play a pivotal role in regulating both amino acid and fatty acid metabolism.
Publish Date	2014-08-17 13:16
Citation	Chandran S, Yap F, Hussain K. Molecular mechanisms of protein induced hyperinsulinaemic hypoglycaemia. World J Diabetes 2014; 5(5): 666-677
URL	http://www.wjgnet.com/1948-9358/full/v5/i5/666.htm
DOI	http://dx.doi.org/10.4239/wjd.v5.i5.666

Full Article (PDF)	WJD-5-666.pdf
Full Article (Word)	WJD-5-666.doc
Manuscript File	9129-Review.docx
Answering Reviewers	9129-Answering reviewers.pdf
Copyright License Agreement	9129-Copyright assignment.pdf
Peer-review Report	9129-Peer review(s).pdf
Scientific Misconduct Check	9129-CrossCheck.jpg
Scientific Editor Work List	9129-Scientific editor work list.pdf