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Articles Published Processes
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Received |
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2014-01-27 11:42 |
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Peer-Review Started |
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2014-01-27 14:51 |
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To Make the First Decision |
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2014-02-28 21:07 |
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Return for Revision |
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2014-03-06 20:02 |
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Revised |
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2014-04-20 00:00 |
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Second Decision |
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2014-06-23 10:05 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-06-23 10:20 |
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Articles in Press |
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2014-06-23 10:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-07-20 19:28 |
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Typeset the Manuscript |
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2014-09-05 17:53 |
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Publish the Manuscript Online |
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2014-09-19 19:25 |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Case Control Study |
Article Title |
Serum immunoglobulin A concentration is a reliable biomarker for liver fibrosis in non-alcoholic fatty liver disease
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Iradj Maleki, Mahmood Reza Aminafshari, Tarang Taghvaei, Vahid Hosseini, Alireza Rafiei, Zhila Torabizadeh, Maryam Barzin and Elahe Orang |
Funding Agency and Grant Number |
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Corresponding Author |
Zhila Torabizadeh, MD, Assistant Professor of Pathology, Department of Pathology, Mazandaran University of Medical Sciences, Imam Khomeini Hospital, Amir Mazandarani Street, Sari 48166-33131,
Iran. zhtorabi@yahoo.com |
Key Words |
Non-alcoholic Fatty Liver Disease; Biological Markers; Immunoglobulin A; Liver Cirrhosis; Fibrosis |
Core Tip |
Nonalcoholic steatohepatitis (NASH) is a severe subtype of Nonalcoholic Fatty Liver Disease (NAFLD) that can progress to advanced liver disease and hepatocellular carcinoma. In this study, we investigated the diagnostic accuracy of serum Immunoglobulin A (IgA) as a biomarker for differentiating early stage NAFLD from NASH. We found that the extent of liver fibrosis correlated positively with IgA levels and these were higher in NASH cases than in non-NASH cases. Based on receiver operating characteristic analysis, the best predictive IgA cutoff value for detecting liver fibrosis was 360 mg/dL (61% sensitivity, 81% specificity). |
Publish Date |
2014-09-19 19:25 |
Citation |
Maleki I, Aminafshari MR, Taghvaei T, Hosseini V, Rafiei A, Torabizadeh Z, Barzin M, Orang E. Serum immunoglobulin a concentration is a reliable biomarker for liver fibrosis in non-alcoholic fatty liver disease. World J Gastroenterol 2014; 20(35): 12566-12573 |
URL |
http://www.wjgnet.com/1007-9327/full/v20/i35/12566.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v20.i35.12566 |
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