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Publication Name World Journal of Gastroenterology
Manuscript ID 9218
Country/Territory
Received
2014-01-27 11:42
Peer-Review Started
2014-01-27 14:51
To Make the First Decision
2014-02-28 21:07
Return for Revision
2014-03-06 20:02
Revised
2014-04-20 00:00
Second Decision
2014-06-23 10:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-06-23 10:20
Articles in Press
2014-06-23 10:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-07-20 19:28
Typeset the Manuscript
2014-09-05 17:53
Publish the Manuscript Online
2014-09-19 19:25
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Case Control Study
Article Title Serum immunoglobulin A concentration is a reliable biomarker for liver fibrosis in non-alcoholic fatty liver disease
Manuscript Source Unsolicited Manuscript
All Author List Iradj Maleki, Mahmood Reza Aminafshari, Tarang Taghvaei, Vahid Hosseini, Alireza Rafiei, Zhila Torabizadeh, Maryam Barzin and Elahe Orang
Funding Agency and Grant Number
Corresponding Author Zhila Torabizadeh, MD, Assistant Professor of Pathology, Department of Pathology, Mazandaran University of Medical Sciences, Imam Khomeini Hospital, Amir Mazandarani Street, Sari 48166-33131, Iran. zhtorabi@yahoo.com
Key Words Non-alcoholic Fatty Liver Disease; Biological Markers; Immunoglobulin A; Liver Cirrhosis; Fibrosis
Core Tip Nonalcoholic steatohepatitis (NASH) is a severe subtype of Nonalcoholic Fatty Liver Disease (NAFLD) that can progress to advanced liver disease and hepatocellular carcinoma. In this study, we investigated the diagnostic accuracy of serum Immunoglobulin A (IgA) as a biomarker for differentiating early stage NAFLD from NASH. We found that the extent of liver fibrosis correlated positively with IgA levels and these were higher in NASH cases than in non-NASH cases. Based on receiver operating characteristic analysis, the best predictive IgA cutoff value for detecting liver fibrosis was 360 mg/dL (61% sensitivity, 81% specificity).
Publish Date 2014-09-19 19:25
Citation Maleki I, Aminafshari MR, Taghvaei T, Hosseini V, Rafiei A, Torabizadeh Z, Barzin M, Orang E. Serum immunoglobulin a concentration is a reliable biomarker for liver fibrosis in non-alcoholic fatty liver disease. World J Gastroenterol 2014; 20(35): 12566-12573
URL http://www.wjgnet.com/1007-9327/full/v20/i35/12566.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i35.12566
Full Article (PDF) WJG-20-12566.pdf
Full Article (Word) WJG-20-12566.doc
Manuscript File 9218-Review.doc
Answering Reviewers 9218-Answering Reviewers.pdf
Copyright License Agreement 9218-Copyright assignment.pdf
Peer-review Report 9218-Peer review.pdf
Scientific Misconduct Check 9218-CorssCheck.jpg
Scientific Editor Work List 9218-Scientific editor work list.pdf