Publication Name	World Journal of Hepatology
Manuscript ID	9278
Country	Türkiye

Received	2014-01-29 22:24
Peer-Review Started	2014-02-08 09:36
To Make the First Decision	2014-02-27 10:32
Return for Revision	2014-03-11 21:19
Revised	2014-03-13 17:47
Second Decision	2014-07-14 17:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-07-14 17:13
Articles in Press	2014-07-14 17:33
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-22 15:55
Typeset the Manuscript	2014-08-28 14:03
Publish the Manuscript Online	2014-08-29 07:54

ISSN	1948-5182 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Circulating microRNAs in patients with non-alcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Mehmet Celikbilek, Mevlut Baskol, Serpil Taheri, Kemal Deniz, Serkan Dogan, Gokmen Zararsız, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Munis Dundar and Mehmet Yucesoy
Funding Agency and Grant Number
Corresponding Author	Mehmet Celikbilek, MD, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey. drcelikbilek@yahoo.com
Key Words	Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; MicroRNA; Noninvasive; Serum markers
Core Tip	Due to the limitations of liver biopsy, the use of non-invasive markers has emerged in recent years. MicroRNAs (miRNAs) are a class of naturally occurring small noncoding RNAs that regulate gene expression. Altered miRNA expression has been reported in animal and human liver samples in non-alcoholic fatty liver disease (NAFLD). There is, however, only limited information on their detection in blood and their correlation with histological disease severity in patients with NAFLD. For this reason, we measured the serum levels of some miRNAs in non-alcoholic steatohepatitis (NASH) patients. Of these microRNAs, miR-181d, miR-99a, miR-197 and miR-146b were expressed at lower levels in NASH patients than in controls. Serum levels of miR-197 and miR-10b were inversely correlated with degree of inflammation and miR-181d and miR-99a were inversely correlated with serum gamma glutamyl transferase levels in NASH patients.
Publish Date	2014-08-29 07:54
Citation	Celikbilek M, Baskol M, Taheri S, Deniz K, Dogan S, Zararsız G, Gursoy S, Guven K, Ozbakır O, Dundar M, Yucesoy M. Circulating microRNAs in patients with non-alcoholic fatty liver disease. World J Hepatol 2014; 6(8): 613-620
URL	http://www.wjgnet.com/1948-5182/full/v6/i8/613.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i8.613

Full Article (PDF)	WJH-6-613.pdf
Full Article (Word)	WJH-6-613.doc
Manuscript File	9278-Review.doc
Answering Reviewers	9278-Answering reviewers.pdf
Copyright License Agreement	9278-Copyright assignment.pdf
Peer-review Report	9278-Peer review(s).pdf
Scientific Misconduct Check	9278-CrossCheck.jpg
Scientific Editor Work List	9278-Scientific editor work list.pdf