Publication Name	World Journal of Gastroenterology
Manuscript ID	9423
Country	China

Received	2014-02-12 02:30
Peer-Review Started	2014-02-13 02:05
To Make the First Decision	2014-03-13 19:01
Return for Revision	2014-03-20 10:07
Revised	2014-04-08 13:25
Second Decision	2014-06-26 16:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-06-26 17:32
Articles in Press	2014-06-26 17:58
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-21 15:18
Typeset the Manuscript	2014-10-23 10:36
Publish the Manuscript Online	2014-11-10 19:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Autobiography
Article Title	N-acetylcysteine attenuates reactive-oxygen-species-mediated endoplasmic reticulum stress during liver ischemia-reperfusion injury
Manuscript Source	Unsolicited Manuscript
All Author List	Yong Sun, Li-Yong Pu, Ling Lu, Xue-Hao Wang, Feng Zhang and Jian-Hua Rao
Funding Agency and Grant Number	Funding Agency Grant Number First Affiliated Hospital of Nanjing Medical University National Natural Science Foundation of China 81100270 National Natural Science Foundation of China 81070380 National Natural Science Foundation of China 81310108001 National Natural Science Foundation of China 81210108017 National Natural Science Foundation of China 81273261
Corresponding Author	Feng Zhang, MD, PhD, Key Laboratory of Living Donor Liver Transplantation of Chinese Ministry of Health, Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. zhangf@njmu.edu.cn
Key Words	N-acetylcysteine; Reactive oxygen species; Endoplasmic reticulum stress; Apoptosis; Liver ischemia-reperfusion
Core Tip	The protective effect of N-acetylcysteine (NAC) treatment has been confirmed in IRI; however, its underlying mechanism remains unclear. Our previous data showed that endoplasmic reticulum (ER) stress is critical for the development of liver IRI. We have found new evidence for the protective effects of NAC on hepatocytes during liver IRI. Our data demonstrated that NAC modulates ER stress signaling and reduces ER-stress-mediated apoptosis during liver IRI. These findings provide further support for the usefulness of exploring NAC as a potential alternative drug for treating liver IRI.
Publish Date	2014-11-10 19:10
Citation	Sun Y, Pu LY, Lu L, Wang XH, Zhang F, Rao JH. N-acetylcysteine attenuates reactive-oxygen-species-mediated endoplasmic reticulum stress during liver ischemia-reperfusion injury. World J Gastroenterol 2014; 20(41): 15289-15298
URL	http://www.wjgnet.com/1007-9327/full/v20/i41/15289.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i41.15289

Full Article (PDF)	WJG-20-15289.pdf
Full Article (Word)	WJG-20-15289.doc
Manuscript File	9423-Review.doc
Answering Reviewers	9423-Answering reviewers.pdf
Copyright License Agreement	9423-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9423-Language certificate.pdf
Peer-review Report	9423-Peer review(s).pdf
Scientific Misconduct Check	9423-CrossCheck.jpg
Scientific Editor Work List	9423-Scientific editor work list.pdf