Publication Name	World Journal of Gastroenterology
Manuscript ID	9682
Country

Received	2014-02-24 09:26
Peer-Review Started	2014-02-24 13:22
To Make the First Decision	2014-03-13 18:55
Return for Revision	2014-03-19 21:21
Revised
Second Decision	2014-05-19 15:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-19 15:28
Articles in Press	2014-05-23 09:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-02 19:48
Publish the Manuscript Online	2014-09-19 19:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Potential mechanisms of hepatitis B virus induced liver injury
Manuscript Source	Invited Manuscript
All Author List	Mohd Suhail, Hany Abdel-Hafiz, Ashraf Ali, Kaneez Fatima, Ghazi A Damanhouri, Esam Azhar, Adeel GA Chaudhary and Ishtiaq Qadri
Funding Agency and Grant Number
Corresponding Author	Dr. Ishtiaq Qadri, King Fahd Medical Research Center, King Abdul Aziz University, PO Box 80216, Jeddah 21589, Saudi Arabia. ishtiaq80262@yahoo.com
Key Words	Hepatitis B virus; Hepatitis B virus genotype; Hepatocellular carcinoma; Woodchuck hepatitis virus; Ground squirrel hepatitis virus; Peripheral blood mononuclear cells; Interferon regulatory factor 7; Interleukin-1 receptor-associated kinase 4; TNF receptor-associated factor 3
Core Tip	There are over 400 million people infected with hepatitis B virus worldwide and chronic active hepatitis is recognized as an important risk factor for liver injury and hepatocellular carcinoma. Cirrhosis is the histological end point of this chronic inflammatory and fibrotic process and is coupled with increased DNA synthesis in cirrhotic as compared to normal livers. The potential mechanism(s) involved in chronic active hepatitis include a combination of processed leading to liver cell necrosis, inflammation and cytokine synthesis and fibrosis. The severity of liver damage is regulated by Hepatitis B virus genotypes and viral components. The viral and cellular factors that contribute to liver injury are discussed in this article. Liver injury caused by the viral infection affects many cellular process such as cell signaling, apoptosis, transcription, DNA repair which in turn induce radical effects on cell survival, growth, transformation and maintenance. The consequence of such perturbations is dictated in bile secretion, gluconeogenesis, glycolysis, detoxification and metabolism of carbohydrates, proteins, and fat and balance of nutrients. The identification and elucidation of the molecular pathways perturbed by the viral protein(s) are important in order to design effective strategy to minimize and/or restore the hepatocyte injury.
Publish Date	2014-09-19 19:25
Citation	Suhail M, Abdel-Hafiz H, Ali A, Fatima K, Damanhouri GA, Azhar E, Chaudhary AGA, Qadri I. Potential mechanisms of hepatitis B virus induced liver injury. World J Gastroenterol 2014; 20(35): 12462-12472
URL	http://www.wjgnet.com/1007-9327/full/v20/i35/12462.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i35.12462

Full Article (PDF)	WJG-20-12462.pdf
Full Article (Word)	WJG-20-12462.doc
Manuscript File	9682-Review.doc
Answering Reviewers	9682-Answering reviewers.pdf
Copyright License Agreement	9682-Copyright assignment.pdf
Peer-review Report	9682-Peer reviewers.pdf
Scientific Editor Work List	9682-Scientific editor work list.pdf