Publication Name	World Journal of Gastroenterology
Manuscript ID	9845
Country	Italy

Received	2014-03-01 16:23
Peer-Review Started	2014-03-01 19:25
To Make the First Decision	2014-04-28 14:10
Return for Revision	2014-05-02 14:28
Revised	2014-06-12 00:24
Second Decision	2014-07-22 16:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-22 17:11
Articles in Press	2014-07-22 18:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-27 10:31
Publish the Manuscript Online	2014-11-10 19:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Enrico Lupia, Luca Pigozzi, Alberto Goffi, Emilio Hirsch and Giuseppe Montrucchio
Funding Agency and Grant Number	Funding Agency Grant Number Ministero dell’Università e della Ricerca Scientifica e Tecnologica (MURST) ex-60% to GM and EL
Corresponding Author	Enrico Lupia, MD, Department of Medical Sciences, University of Torino, Via Genova 3, 10126 Torino, Italy. enrico.lupia@unito.it
Key Words	Phosphoinositide 3-kinase; Cell signaling; Inflammation; Pathogenesis; Acute pancreatitis
Core Tip	Phosphoinositide 3-kinases (PI3Ks) are a family of lipid and protein kinases implicated in intracellular signal transduction and regulation of inflammation. Recent data suggest their involvement also in the pathogenesis of acute pancreatitis. PI3Ks, and in particular the PI3K? isoform, have a significant role in those events which are necessary for the initiation of acute pancreatic injury, namely calcium signaling alteration, trypsinogen activation, and nuclear factor-?B transcription. Moreover, PI3K? modulates acinar cell apoptosis, and regulates local and systemic inflammatory responses during experimental acute pancreatitis. Specific PI3K inhibitors may therefore provide new therapies to improve the clinical course of this disease.
Publish Date	2014-11-10 19:10
Citation	Lupia E, Pigozzi L, Goffi A, Hirsch E, Montrucchio G. Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis. World J Gastroenterol 2014; 20(41): 15190-15199
URL	http://www.wjgnet.com/1007-9327/full/v20/i41/15190.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i41.15190

Full Article (PDF)	WJG-20-15190.pdf
Full Article (Word)	WJG-20-15190.doc
Manuscript File	9845-Review.docx
Answering Reviewers	9845-Answering reviewers.pdf
Copyright License Agreement	9845-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9845-Language certificate.pdf
Peer-review Report	9845-Peer review(s).pdf
Scientific Misconduct Check	9845-CrossCheck.jpg
Scientific Editor Work List	9845-Scientific editor work list.pdf