BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
11/10/2014 7:09:00 PM | Browse: 1093 | Download: 1115
Publication Name World Journal of Gastroenterology
Manuscript ID 9904
Country/Territory Saudi Arabia
Received
2014-03-03 21:32
Peer-Review Started
2014-03-04 08:24
To Make the First Decision
2014-03-27 20:59
Return for Revision
2014-03-31 10:22
Revised
2014-06-29 00:00
Second Decision
2014-07-11 17:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-11 17:20
Articles in Press
2014-07-11 17:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-08-03 20:11
Typeset the Manuscript
2014-10-26 15:44
Publish the Manuscript Online
2014-11-10 19:10
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combination
Manuscript Source Unsolicited Manuscript
All Author List Ayman I Elkady, Rania Abd El Hamid Hussein and Osama A Abu-Zinadah
Funding Agency and Grant Number
Funding Agency Grant Number
Deanship of Scientific Research, King Abdulaziz University 1431/130/159
Corresponding Author Dr. Osama A Abu-Zinadah, Professor of Cell Biology and Histology, Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia. oaboznada@kau.edu.sa
Key Words Apoptosis; Colorectal cancer; Oncogenes; Phytochemicals; Tumor suppressor proteins
Core Tip Many medicinal plants represent a cornerstone for chemoprevention of colorectal cancer (CRC). Nonetheless, monotherapy with these agents has been unsatisfactory; therefore attention has turned towards therapies combining these plant-based extracts. In this study, we found that a combination of crude alkaloid and flavonoid extracts prepared from the medicinal herbs Rhazya stricta and Zingiber officinale, respectively, acted synergistically to suppress proliferation, induce apoptosis and modulate expression levels of cell cycle regulatory proteins in CRC cells. These results provide a foundation and rationale for exploiting these extracts for the prevention of CRC.
Publish Date 2014-11-10 19:10
Citation Elkady AI, Hussein RAEH, Abu-Zinadah OA. Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combination. World J Gastroenterol 2014; 20(41): 15275-15288
URL http://www.wjgnet.com/1007-9327/full/v20/i41/15275.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i41.15275
Full Article (PDF) WJG-20-15275.pdf
Full Article (Word) WJG-20-15275.doc
Manuscript File 9904-Review.docx
Answering Reviewers 9904-Answering Reviewers.pdf
Copyright License Agreement 9904-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate Editing_Certificate_20140303132133.pdf
Peer-review Report 9904-Peer reviews.pdf
Scientific Misconduct Check 9904-CrossCheck.jpg
Scientific Editor Work List 9904-Scientific editor work list.pdf