| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Beneficial effect of an omega-6 PUFA-rich diet in non-steroidal anti-inflammatory drug-induced mucosal damage in the murine small intestinez
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Toshihide Ueda, Ryota Hokari, Masaaki Higashiyama, Yuichi Yasutake, Koji Maruta, Chie Kurihara, Kengo Tomita, Shunsuke Komoto, Yoshikiyo Okada, Chikako Watanabe, Shingo Usui, Shigeaki Nagao and Soichiro Miura |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Defense Medical College |
|
| Health and Labour Sciences Research Grants |
|
| Research for the similarity and difference in epidemiology, pathophysiology, diagnosis and treatment of rare intestinal refractory diseases |
|
| Smoking Research Foundation |
|
|
| Corresponding Author |
Ryota Hokari, MD, Professor, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. ryota@ndmc.ac.jp |
| Key Words |
Non-steroidal anti-inflammatory drugs; Small intestine; Ulcer; Dietary fat; Adhesion molecules |
| Core Tip |
Non-steroidal anti-inflammatory drugs (NSAIDs) frequently induce mucosal damage in the gastrointestinal tract. The recently developed techniques of capsule enteroscopy and double balloon enteroscopy have shown that NSAIDs cause ulcers in the small intestine (68%) more frequently than previously thought. Although proton pump inhibitors are key drugs for NSAIDs-induced gastropathy, proton pump inhibitors have no effect on NSAIDs-induced intestinal lesions and no drugs are currently available for the prevention and treatment of NSAIDs-induced intestinal lesions. In the present study, we showed the beneficial effect of an omega-6 PUFA-rich diet in NSAID-induced mucosal damage in the murine small intestine. This is a completely novel finding and is important not only in the clinical field, but also in preventive medicine. |
| Publish Date |
2015-01-07 11:07 |
| Citation |
Ueda T, Hokari R, Higashiyama M, Yasutake Y, Maruta K, Kurihara C, Tomita K, Komoto S, Okada Y, Watanabe C, Usui S, Nagao S, Miura S. Beneficial effect of an omega-6 PUFA-rich diet in non-steroidal anti-inflammatory drug-induced mucosal damage in the murine small intestine. World J Gastroenterol 2015; 21(1): 177-186 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i1/177.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i1.177 |
