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Reader Comments
Publication Name
Article Title
Year Published
1
"the author should have concentrated in the study either on neoplastic or non neoplastic cyst of pancrease the title should be more clarified and more representative of the study abstract didn't represent the all aspects and results of study " 
Muniraj T, Aslanian HR, Laine L, Jamidar PA, Farrell JF, Mitchell KA, Salem RR. Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies. World J Gastroenterol 2021; 27(15): 1630-1642 [DOI: 10.3748/wjg.v27.i15.1630]
2
"I recognize that ABI-WAVE2 pathway has long been recognized as a pathway contributing to the adhesive and migration properties of the cells. This report referred to the role of ABI-SiL in the inhibiting effect against cell migration via hindering ABI-WAVE2 pathway and consequent function in treating metastasis of colon cancer. Therefore, the authors should pay more attention to the expression of ABI-SiL in patients with metastatic colon cancer. In order to delineate the functions of ABI1-SiL, the authors should knockout the ABI-SiL in a cell line that expresses this isoform and observe the following change of the characteristics of the cell line. Regarding Figure 7C and D, I am concerned that ABI1-p65 and ABI1-SiL do not bind to WAVE2 in SW480-V cells as the annotation demonstrates. In respect of Figure 7E, I am concerned that the bidirectional co-IP and Western blot analysis did not prove the direct interaction between ABI1-SiL and ABI1-p65 as the annotation demonstrates; moreover, the co-localization between ABI1-SiL and ABI1-p65 is not a strong evidence of the interaction between these two proteins: it is possible that ABI1-SiL, ABI-p65 and WAVE2 form a complex in the cells. In the third paragraph of Discussion, the authors misspelled “decrease” as “decresion”. Just as discussed in the article, I am looking forward to more work about the effect of ABI1-SiL on animal experiment. Moreover, I think the authors should compare the characteristic of the tumor in which ABI1-SiL decreased with that of the tumor that ABI-SiL remained unchanged. Besides, as the isoforms share the same opening reading frame as ABI1 and the mRNA level of ABI-p65 remains the same, I am curious about the mechanism under the differential expression of the isoforms. " 
Li K, Peng YF, Guo JZ, Li M, Zhang Y, Chen JY, Lin TR, Yu X, Yu WD. Abelson interactor 1 splice isoform-L plays an anti-oncogenic role in colorectal carcinoma through interactions with WAVE2 and full-length Abelson interactor 1. World J Gastroenterol 2021; 27(15): 1595-1615 [DOI: 10.3748/wjg.v27.i15.1595]
3
"The article reviewed a new concept for assessing the outcomes of the hepatopancreatobiliary surgery. The article helps readers to understand what is the "textbook outcome" indicates." 
Tsilimigras DI, Pawlik TM, Moris D. Textbook outcomes in hepatobiliary and pancreatic surgery. World J Gastroenterol 2021; 27(15): 1524-1530 [DOI: 10.3748/wjg.v27.i15.1524]
4
"The article is a very informative case report which provides readers to understand pathological/morphological/clinical features of invasive micropapillary carcinoma of the ampulla of the Vater. This case report is excellent in terms of describing specific clinical course of the patient and easy-to-read figures/tables." 
Noguchi H, Higashi M, Idichi T, Kurahara H, Mataki Y, Tasaki T, Kitazono I, Ohtsuka T, Tanimoto A. Rare histological subtype of invasive micropapillary carcinoma in the ampulla of Vater: A case report. World J Clin Cases 2021; 9(11): 2671-2678 [DOI: 10.12998/wjcc.v9.i11.2671]
5
"Point-of-care ultrasound: Clinician's Visualization Stethoscope Haitao Liu 1， Qi Chen 2 ，Yang Gao 3* 1 2 Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin 150081, Heilongjiang, China 3 Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin 150081, Heilongjiang, China *Corresponding Author of this Comment :Yang Gao Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin 150081, Heilongjiang, China. E-mail：gaoyang0312@126.com We recently read this case report about “Point-of-care ultrasound for the early diagnosis of emphysematous pyelonephritis”. Emphysematous pyelonephritis is rare in clinic, its onset is sudden and its condition is dangerous. Point-of-care ultrasound for the early diagnosis of emphysematous pyelonephritis is very important for the early diagnosis of critical patients. This early ultrasound diagnosis method is a new idea for the clinical application of critical ultrasound. Point-of-care ultrasound examinations are usually used in emergency and endangering the patient’s vital signs to speed up patient diagnosis and treatment. Because point-of-care ultrasound performs a single or limited examination for a specific clinical phenotype, it greatly shortens the examination time. Anesthesiologists, ICUs, and emergency physicians most need to master point-of-care ultrasound technology. Experts in different fields like to name their own field, such as critical ultrasound, emergency ultrasound, or anesthesia ultrasound. No matter what the name is, the purpose is the same. It is hoped that real-time ultrasound at the bedside can provide many physical examinations and information that cannot be provided by various monitoring equipment, so as to achieve rapid, dynamic and visual acquisition of the patient's pathophysiological state, and for visual guidance Provide help for operations such as puncture." 
Xing ZX, Yang H, Zhang W, Wang Y, Wang CS, Chen T, Chen HJ. Point-of-care ultrasound for the early diagnosis of emphysematous pyelonephritis: A case report and literature review . World J Clin Cases 2021; 9(11): 2584-2594 [DOI: 10.12998/wjcc.v9.i11.2584]
6
"This paper mainly discussed the relationship between intestinal bacteria in early organ failure SAP, which is a good story in the clinical treatment of AP. I think that if the article proved the figure about the characteristic of intestinal bacteria, it will be better to reader." 
Liang XY, Jia TX, Zhang M. Intestinal bacterial overgrowth in the early stage of severe acute pancreatitis is associated with acute respiratory distress syndrome. World J Gastroenterol 2021; 27(15): 1643-1654 [DOI: 10.3748/wjg.v27.i15.1643]
7
"The manuscript entitled " Intestinal bacterial overgrowth in the early stage of severe acute pancreatitis is associated with acute respiratory distress syndrome " is comprehensive study of the examining the intestinal bacterial overgrowth in the early stage in acute pancreatic. Title of article is appropriate. Abstract is good arranged. Introduction is good organized with sufficient literature review. Methods are evidence based. Results show findings clearly. Conclusion is logical and appropriate. References are related to the issue. I think the figures, tables and highlights are important and help to better understanding of the subject. " 
Liang XY, Jia TX, Zhang M. Intestinal bacterial overgrowth in the early stage of severe acute pancreatitis is associated with acute respiratory distress syndrome. World J Gastroenterol 2021; 27(15): 1643-1654 [DOI: 10.3748/wjg.v27.i15.1643]
8
"Readers comment I have some corrections to improve the article value that I describe in "the following queries (Q)". Six coronaviruses reported as human-affected viruses include α- coronaviruses NL63 and 229E, low-pathogenic β-coronaviruses OC43 and HKU1, these viruses cause mild respiratory symptoms as common cold [2]. The remaining two types were identified as β-coronavirus, which unusually induced fatal respiratory tract infections [3]. Q1. In those aforementioned sentences, author mentioned six types of coronavirus, but author just describe four types “α-coronaviruses NL63 and 229E, low-pathogenic β-coronaviruses OC43 and HKU1”. Even though author mentioned the remaining two types were identified as β-coronavirus however author did not mention these two types, my suggestion is better to put remaining two types were identified as β-coronavirus Q2. First paragraph in sentence “Between 2002 and 2003, severe acute respiratory syndrome (SARS) resulted in the outbreak of SARS0[4]….Please correct typos of SARS0 Q3. Paragraph 3 “On the same day, the international committee of taxonomy named this virus as SARS-CoV-2 and classified it as coronavirus under the family Coronaviridae, subfamily Orthocoronavirinae, based on the genotypic and serological characterization”. Please correct the sentence and give the abbreviation of international committee on taxonomy of virus (ICTV)” Q4: Why author just focused on the Cytokine and ACE-2, currently there are so many gene that was reported such as TMPRSS2. It will be better if author include explanation of TMPRSS2 as well. Hoffmann, H. Kleine-Weber, S. Schroeder, N. Kruger, T. Herrler, S. Erichsen,T.S. Schiergens, G. Herrler, N.H. Wu, A. Nitsche, M.A. Muller, C. Drosten,S. Pohlmann, SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and isblocked by a clinically proven protease inhibitor, Cell 181 (2) (2020) 271e280,https://doi.org/10.1016/j.cell.2020.02.052 Irham LM, Chou WH, Calkins MJ, Adikusuma W, Hsieh SL, Chang WC. Genetic variants that influence SARS‐CoV‐2 receptor TMPRSS2 expression among population cohorts from multiple continents. Biochem Res Commun. 2020;529(2):263‐269. Q5. Author mentioned “ SARS-CoV-2 may induce liver injury via a similar mechanism”. Which is the similar mechanis?. As reader I could not identified which mechanism Q6: Please cite the reference in the sentence” Patients with digestive issues and co-infected with SARS-CoV-2 show a higher risk of mortality than patients without digestive problems.” Q7: In part of Hepatitis B and COVID19. Author mentioned that “For patients with chronic hepatitis B and are in the immune tolerance phase, further tests are required to confirm whether these patients have active viral replication and repeated liver damage after co-infection with SARS-CoV-2” It is important point to elaborate more detail the Hepatitis B and COVID-19 in immune tolerance phase. It is better to mention the characterize of Immune intolerant phase. In this phase (immune tolerance phase) characterize by high level of HBV biomarkers such as HBsAg and HBeAg, but low level of ALT. it is mostly indicated the low inflammatory in this phase. Q8: In conclusion in the sentence “In this review, we concluded that the most destructive power of the virus is the generation of violent cytokine storm, which is probably the cause of high mortality rates in hepatic and nonhaptic patients”. I think it is better to not use the most destructive power of the virus is the generation of violent cytokine storm. Because current study does not perform analysis that reflect the most destructive power of the virus is the generation of violent cytokine storm, " 
Ali FEM, Mohammedsaleh ZM, Ali MM, Ghogar OM. Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges. World J Gastroenterol 2021; 27(15): 1531-1552 [DOI: 10.3748/wjg.v27.i15.1531]
9
"The findings of this case are meaningful and the conclusions are important implications for clinical neurologist. In clinical, sudden hearing loss (SHL) and vertigo are both common symptoms. Usually, it's considered that SHL is mainly due to blood circulation disorder of the inthe internal auditory artery (IAA) which originating from the anterior inferior cerebellar artery(AICA) and in the absence of obvious stroke symptoms and excluding peripheral vertigo, disturbance of posterior circulation is the primary cause of vertigo. Brain imagings including CT and MRI are usually recommended to help find lesions, but not done in all clinical practice. The authors reported a case of SHL and vertigo as first symptoms that was finally diagnosed as cerebral infarction, and they suggest that SHL and vertigo could be the initial symptoms of vertebrobasilar ischemic stroke. It has implications for clinical practice, especially for the early identification of acute posterior circulation stroke. The cited references are recommended to be the latest, important and authoritative." 
Wang XL, Sun M, Wang XP. Cerebellar artery infarction with sudden hearing loss and vertigo as initial symptoms: A case report. World J Clin Cases 2021; 9(11): 2519-2523 [DOI: 10.12998/wjcc.v9.i11.2519]
10
"Should people with chronic liver disease be vaccinated against COVID-19? Coronavirus disease 2019 (COVID-19) has become a global epidemic. It is not just a threat to public health, but also a major blow to economic development and regional stability. SARS-CoV-2 enters host cells by attaching to angiotensin-converting enzyme 2 (ACE2). ACE2 is not simply located in the respiratory tract, but also in the kidney, heart, skeletal muscle, central nervous system, liver, and gastrointestinal tract. Therefore, patients with severe COVID-19 show multiple organ dysfunction. Distribution of ACE2 in liver was unique. Chai, et al found that ACE2 was more highly expressed in cholangiocytes (59.7%) than hepatocytes (2.6%). The level of ACE2 expression in cholangiocytes was comparable to that in type 2 alveolar cells of the lungs, indicating that the liver impairment in COVID‐19 may be originated from damage to the cholangiocytes in the beginning, not directly infection of hepatocytes. Of course, hepatocyte damage in severe cases can also be indirectly induced by the systemic inflammatory response and abnormal metabolism. According to previous meta-analysis, Abnormal alanine transaminase (ALT), aspartate transaminase (AST) and bilirubin were reported in 15.0%, 15.0%, and 16.7% of all patients. However, the severity of liver impairment, clinical outcomes and mortality rate for patients under different chronic liver disease conditions co-infected with SARS-CoV-2 is less noticed. The present review summarizes the impact of SARS-CoV-2 on different chronic liver disease conditions, exhibited overexpression of ACE2 and cytokine storm overwhelming. These might worsen the liver impairment and increase the mortality rate. SARS-CoV-2 vaccines are regarded as the most effective weapon to end the epidemic. Countries around the world are working intensively to develop and produce vaccines. The consensus was reached that we should get as many people vaccinated as possible in order to achieve herd immunity. People with stable chronic liver disease conditions are capable of being included in clinical trials of mRNA BNT162b2, mRNA-1273 vaccine and CoronaVac, BBIBP-CorV Inactivated vaccine. It has proven to be safe and well tolerated. Consider the poor outcomes and high mortality rate of chronic liver disease co-infected with SARS-CoV-2 as stated in this article, the AASLD Expert Panel propose suggestions that COVID-19 vaccines should be given to all adult patients with chronic liver disease and liver transplant recipients. Moreover, patients with chronic liver disease who are receiving antiviral therapy for HBV or HCV should NOT withhold their medications while receiving the COVID-19 vaccines. Patients with hepatocellular carcinoma undergoing locoregional or systemic therapy should also be considered for vaccination without interruption of their treatment. mRNA COVID-19 vaccines are expected to have a favorable efficacy and safety profile in immunosuppressed patients and should be administered according to their standard dose and schedule. Liver transplant candidates with chronic liver disease should receive the mRNA COVID-19 vaccine prior to transplantation. " 
Ali FEM, Mohammedsaleh ZM, Ali MM, Ghogar OM. Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges. World J Gastroenterol 2021; 27(15): 1531-1552 [DOI: 10.3748/wjg.v27.i15.1531]
11
"I recognize that LGR5 and BMI1 are representative intestinal stem cell (ISC) markers. At the same time, LGR5 and BMI1 are also known to colorectal cancer stem cell (CSC) markers. This report referred to the cancer stem cells, using famous two cell lines: Caco-2 and Lovo. Therefore, the authors should discuss the relation between colorectal CSCs and LGR5 more in detail in Introduction and discussion. Moreover, the authors did not refer to the relation between colorectal CSCs and BMI1 at all. In contrast, the authors should reduce amount of the description about the relation between ISCs and Lgr5. ISCs did not relate with the main stream of the report. In discussion, the authors should discuss about underling mechanisms why LGR5-negative cells of Lovo could have stemness nature. For examples, RNA-seq from EYFP-positive or EYFP-negative cells of Lovo could help the understanding of different gene expression profile of CSCs and non-CSCs. Regarding Cell culture, the authors should confirm the possibility of mycoplasma infection. Regarding Figure 1I and 1J, I was concerned about stemness properties of LGR5-negative (EYFP-negative) tumor cells. In Figure 1I and 1J, the number of LGR5-negative cells increased day by day. The finding mean that LGR5-negative cells also had a capacity of producing their descendant (LGR5-negative) cells. Therefore, the authors should compare the productivity of daughter cells of LGR5-positive and LGR5-negtive cells (e.g. MTT assay). Regarding Figure 2, the authors confused ISC markers and CSC markers. The authors should refer to OLFM4, TERT…, as CSC markers, not as ISC markers. And they should displaye the number of samples. Regarding Figure4, the number of samples was too small (n = 3). The authors should perform xenograft experiments enough times to make a statistics analysis." 
Alharbi SA, Ovchinnikov DA, Wolvetang E. Leucine-rich repeat-containing G protein-coupled receptor 5 marks different cancer stem cell compartments in human Caco-2 and LoVo colon cancer lines. World J Gastroenterol 2021; 27(15): 1578-1594 [DOI: 10.3748/wjg.v27.i15.1578]
12
"It is an interesting study that the potential role of CXCL12 isoforms enhancing the metastatic tendency of pancreatic cancer was confirmed. It is wondering if three CXCL12 isotypes have differently interacted with CXCR4 in pancreatic cancer cells." 
Cecati M, Giulietti M, Righetti A, Sabanovic B, Piva F. Effects of CXCL12 isoforms in a pancreatic pre-tumour cellular model: Microarray analysis. World J Gastroenterol 2021; 27(15): 1616-1629 [DOI: 10.3748/wjg.v27.i15.1616]
13
"This review summarized the latest findings that COVID-19 exacerbate liver damage of liver diseases and the latest treatment recommendations for these kinds of patient. This review first pointed out that the SARS-CoV-2 infection caused a large proportion of patients with liver function abnormalities, and the patients with pre-existing liver disease (ALD, NAFLD, HBV or HCV infection) were more susceptible to the COVID-19 induced liver damage or drug-induced liver damage during the treatment. On the other hand, the author further proposed the mechanism of liver damage in this process, such as direct virus damage, cytokine storm, coagulative and fibrinolytic pathways. Finally, the author also listed the current recommendations for diagnosing and treating COVID-19 infection, in particular, for patients with pre-existing liver disease. However, there are also some ambiguities. For example, some of the data in Figure 1 showed the liver function abnormalities after COVID-19 infection, and others were the data about the liver damage in patients with pre-existing liver disease after COVID-19 infection." 
Ahmad A, Ishtiaq SM, Khan JA, Aslam R, Ali S, Arshad MI. COVID-19 and comorbidities of hepatic diseases in a global perspective. World J Gastroenterol 2021; 27(13): 1296-1310 [PMID: 33833483 DOI: 10.3748/wjg.v27.i13.1296]
14
"The authors seem to deal with an important topic carrying on HCV cure in pediatric patient. The study rational, aim and research motivation are relevant and enough well stated. The bibliographic search method seems to be omitted as well as the search date or period. The findings and/or conclusion answer to the study aim to a degree: “No pediatric studies with the children completing the DAA therapy has revealed evidence of children being unresponsive to DAA therapies. However, for patients with evidence of high-grade fibrosis or cirrhosis, they are still at high risk of developing HCC even after achieving SVR. Solid organ transplant from HCV infected recipients appears to be safe, is associated with excellent outcomes, and should be considered for recipients who would benefit from receiving an organ earlier than they would if they waited for an organ from an uninfected donor. Thus, reducing wait-list associated mortality. While no studies has been performed, based on the efficacy of DAA therapy in children, using HCV-infected donors should be an option. As children will now have access to DAA therapies and potential HCV cure, it is imperative that diagnosis and treatment of this population is not overlooked. A related issue is for patients with chronic liver disease to avoid COVID-19 exposure and infection, by educating patients/parents on the risk and the recommended precautions cure, it is imperative that diagnosis and treatment of this population is not overlooked. This is especially true in rare cases of children with cirrhosis or end stage liver disease secondary to HCV, as there appears to be a higher risk of a severe course of COVID-19. This pandemic should not be a hindrance to continuing the goal of eradication of HCV in the pediatric population. Enhanced screening and awareness efforts and continued education of healthcare providers will improve the outcomes of HCV infection in the pediatric population”. This review may be an informative and useful document for students, clinicians and researchers a fortiori those working in pediatric or hepatology field. However we have some observations to make: The authors noticed in Page 6-13: 1. “Introduction”: you noticed “Non- , Non-B Hepatitis”. I think that you omitted the “A” related to hepatitis A. You should write Non-A,….”. 2. “Epidemiology”: you noticed “All 6 HCV genotypes…”. However, to date 8 genotypes are identified for HCV. 3. “Natural history”: “Albeit uncommon, progression to cirrhosis has been described and…”. This sentence may be reformulated for better readability and comprehension. 4. “Improving the cascade or care”: ”KHAMP has trained primary care providers on HCV epidemiology, diagnosis, management…”. This sentence may be reformulated, because the word "management" means prevention, diagnosis, treatment and monitoring or follow up. 5. “Conclusion”: “…a major impact on health care outcomes for patients of all ages…including…”. In this sentence "...including" may be replaced by "a fortiori". " 
Rogers ME, Balistreri WF. Cascade of care for children and adolescents with chronic hepatitis C. World J Gastroenterol 2021; 27(12): 1117-1131 [PMID: 33828389 DOI: 10.3748/wjg.v27.i12.1117]
15
"The case report provided new aspect of re-treatment with NSCLC patients who developed resistance to EGFR-TKIs, and inspired the clinician to manage the difficult condition." 
Hu XY, Fei YC, Zhou WC, Zhu JM, Lv DL. Triple administration of osimertinib followed by chemotherapy for advanced lung adenocarcinoma: A case report. World J Clin Cases 2021; 9(11): 2627-2633 [DOI: 10.12998/wjcc.v9.i11.2627]
16
"The procedure is interesting. The used of endoprosthesis with giant cell tumor of bone with limited resection of tumor. The concerning point may be recurrence of tumor after limited resection to keep soft tissue reconstruction." 
Wang J, Zhou Y, Wang YT, Min L, Zhang YQ, Lu MX, Tang F, Luo Y, Zhang YH, Zhang XL, Tu CQ. Three-dimensional-printed custom-made patellar endoprosthesis for recurrent giant cell tumor of the patella: A case report and review of the literature. World J Clin Cases 2021; 9(11): 2524-2532 [DOI: 10.12998/wjcc.v9.i11.2524]
17
"It's very good." 
Joseph DF, Li E, Stanley III SL, Zhu YC, Li XN, Yang J, Ottaviano LF, Bucobo JC, Buscaglia JM, Miller JD, Veluvolu R, Follen M, Grossman EB. Impact of type 2 diabetes on adenoma detection in screening colonoscopies performed in disparate populations. World J Clin Cases 2021; 9(11): 2433-2445 [DOI: 10.12998/wjcc.v9.i11.2433]
18
"Intersting paper " 
Wang Q, Niu XY, Feng H, Wu J, Gao W, Zhang ZX, Zou YW, Zhang BY, Wang HJ. Gastrointestinal-type chemotherapy prolongs survival in an atypical primary ovarian mucinous carcinoma: A case report. World J Clin Cases 2021; 9(11): 2533-2541 [DOI: 10.12998/wjcc.v9.i11.2533]
19
"Very Interesting paper and provide novel data." 
Fan JZ, Wang GF, Cheng XB, Dong ZH, Chen X, Deng YJ, Song X. Relationship between mismatch repair protein, RAS, BRAF, PIK3CA gene expression and clinicopathological characteristics in elderly colorectal cancer patients. World J Clin Cases 2021; 9(11): 2458-2468 [DOI: 10.12998/wjcc.v9.i11.2458]
20
"This manuscript is a good collection of results that aim to determine the impact of hyper-transfusion on long term survival in pediatric living donor liver transplantation. Overall, the information are well collected. However, there are some important issues I would like to emphasize. 1. Method: The authors need to clarify what is (are) the primary outcomes of the study and what are the secondary outcomes of the study. The other minor findings can be described in the results but the discussion should be based on the outcomes of interest. 2. Results: Since hyper-transfusion may be the cause of an excess ten year mortality or an epiphenomenon (difficult patients, difficult medical care etc), the authors need to perform additional competing risk analysis to define the impact of hyper-transfusion on the ten year patient survival. As to the result, hyper-transfusion is significantly associated with 30 day reoperation and 30 day excess mortality, this factor need to be consider as a competing risk for long term survival. In addition, the impact of other set of risk factors should be analyzed for the association with ten year survival. 3. Discussion: Need to be reorganized according to the revised method and results. 4. The impact of hyper-transfusion on the outcome of pediatric living donor transplantation should be clearly stated. 5. Tables 3 and 5 . The information can be limited to what are related with the potential adverse events of hyper-transfusion on the primary and secondary outcomes. " 
Gordon K, Figueira ERR, Rocha-Filho JA, Mondadori LA, Joaquim EHG, Seda-Neto J, da Fonseca EA, Pugliese RPS, Vintimilla AM, Auler Jr JOC, Carmona MJC, D'Alburquerque LAC. Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation. World J Gastroenterol 2021; 27(12): 1161-1181 [PMID: 33828392 DOI: 10.3748/wjg.v27.i12.1161]
21
"Letter to editor: The World Health Organization (WHO) reported that the total number of people currently infected with HCV was approximately 185 million. Compared with adults, children and adolescents are more insidious in HCV infection, which is a public health issue that deserves great attention[1]. The estimated prevalence of HCV infection in children and adolescents is 0.15% globally, corresponding to 3.5 million patients (95% CI 3.1-3.9 million)[2]. Rogers et al comprehensively summarized the current status of HCV infection, clinical treatment strategies, clinical outcomes, diagnosis and screening in children and adolescents and point out the focus of the prevention and control of HCV to achieve the WHO goal of eliminating hepatitis in the future. For the epidemiology of HCV, this review indicated that the prevalence of HCV is increasing year by year in children and adolescents, while it is decreasing in adults. In developing countries with large populations, children’s health care was very worrying, and the prevention and treatment of HCV was even more severe, the prevalence of HCV among street children in Iran was found to be at 2.4% (95% CI: 1.8-3.3)[3]. Although vertical transmission is now the main route of HCV transmission among children and adolescents, in developing countries children who need special medical treatment, such as surgical resection, hemodialysis, and kidney transplantation, suffering higher risk of get HCV infection[4][5]. In addition, as injecting drug use becomes more and more common among children and adolescents, the risk of get HCV infection is gradually increasing. Before the 1990s, children were infected with HCV mainly through blood, blood products, or organ transplantation. Since the implementation of HCV screening of blood donors in various countries in 1992, vertical transmission has become the most important way for children to contract HCV. Although the spontaneous clearance rate of HCV through vertical transmission in children and adolescents was higher than that in adults, Modin et al reported liver disease developed in 32% of patients at a median of 33 years, the incidence of hepatocellular carcinoma was 5%, liver transplant 4% and death occurred in 3%[6]. It is worth that advanced liver disease and decompensated cirrhosis had been identified in children as young as 3 years old and as early as 1 year after infection.[7, 8] At present, the diagnosis of hepatitis C can be achieved through HCV antibody detection and HCV-RNA detection, but the status of patient’s liver damage cannot be grasped. Although the guidelines have not formally recommended the use of non-invasive methods for grading necroinflammatory activity and staging of fibrosis in routine clinical practice in children and adolescents, it can be considered for use before completing performance studies[9, 10]. In terms of treatment, the author comprehensively summarized the application status of direct-acting antiviral regimens in children and adolescents, including the therapeutic effects of different HCV gene types. However, among children and adolescents with HCV, there may be cases of receiving long-term dialysis and for the treatment of the above special populations, special attention should be paid to the possible toxic side effects of drugs. Since direct-acting antiviral regimens were not approved for HCV infected people younger than 18 years old until 2017, the prevention and treatment of HCV in children and adolescents has not received sufficient attention as in adults. Moreover, the focus of the global hepatitis has been on treatment and prevention among adult population, which bears the greatest burden of HCV. However, to realize the goal of eliminating HCV infection, all affected populations, including children and adolescents, should be taken seriously. There was still much work to be done in the prevention of HCV in children and adolescents. On the one hand, there is an urgent need to strengthen sexual education for teenagers and children and avoid drug use. On the other hand, clinical experimental research on the treatment of HCV in pregnant women should be accelerated to minimize the risk of vertical transmission. References: 1 Guidelines for the Screening Care and Treatment of Persons with Chronic Hepatitis C Infection: Updated Version. Geneva: World Health Organization, 2016. 2 Indolfi G, Easterbrook P, Dusheiko G, El-Sayed MH, Jonas MM, Thorne C, Bulterys M, Siberry G, Walsh N, Chang MH, Meyers T, Giaquinto C, Wirth S, Chan PL, Penazzato M. Hepatitis C virus infection in children and adolescents. Lancet Gastroenterol Hepatol 2019 2019-06-01; 4(6): 477-487. 3 Behzadifar M, Gorji HA, Rezapour A, Bragazzi NL. Prevalence of hepatitis C virus among street children in Iran. INFECT DIS POVERTY 2018 2018-10-01; 7(1): 88. 4 Ahmadi SM, Raeessi N. Assessing the prevalence of HBV and HCV infections in children under going hemodialysis and the related risk factors in a children's Medical Center: PS132. Porto Biomed J 2017 2017-09-01; 2(5): 236. 5 Seerat I, Mushtaq H, Rafiq M, Nadir A. Frequency and Associated Risk Factors of Hepatitis B Virus and Hepatitis C Virus Infections in Children at a Hepatitis Prevention and Treatment Clinic in Lahore, Pakistan. Cureus 2020 2020-05-02; 12(5): e7926. 6 Modin L, Arshad A, Wilkes B, Benselin J, Lloyd C, Irving WL, Kelly DA. Epidemiology and natural history of hepatitis C virus infection among children and young people. J HEPATOL 2019 2019-03-01; 70(3): 371-378. 7 Guido M, Bortolotti F, Leandro G, Jara P, Hierro L, Larrauri J, Barbera C, Giacchino R, Zancan L, Balli F, Crivellaro C, Cristina E, Pucci A, Rugge M. Fibrosis in chronic hepatitis C acquired in infancy: is it only a matter of time? AM J GASTROENTEROL 2003 2003-03-01; 98(3): 660-663. 8 Rumbo C, Fawaz RL, Emre SH, Suchy FJ, Kerkar N, Morotti RA, Shneider BL. Hepatitis C in children: a quaternary referral center perspective. J Pediatr Gastroenterol Nutr 2006 2006-08-01; 43(2): 209-216. 9 Fitzpatrick E, Quaglia A, Vimalesvaran S, Basso MS, Dhawan A. Transient elastography is a useful noninvasive tool for the evaluation of fibrosis in paediatric chronic liver disease. J Pediatr Gastroenterol Nutr 2013 2013-01-01; 56(1): 72-76. 10 Lee CK, Perez-Atayde AR, Mitchell PD, Raza R, Afdhal NH, Jonas MM. Serum biomarkers and transient elastography as predictors of advanced liver fibrosis in a United States cohort: the Boston children's hospital experience. J Pediatr 2013 2013-10-01; 163(4): 1058-1064. " 
Rogers ME, Balistreri WF. Cascade of care for children and adolescents with chronic hepatitis C. World J Gastroenterol 2021; 27(12): 1117-1131 [PMID: 33828389 DOI: 10.3748/wjg.v27.i12.1117]
22
"The review was very informative for a non-expert and recapitulated many aspects of interest, covering updated progress and additional challenges that need to be overcome. Section 1&2: Introduction/ Brief summary of autoimmunity in T1DM The authors should have merged the first two sections after the abstract. The review would flow better, if the second main section (Brief summary of autoiimunity in T1DM) came after the first paragraph of the first section (Introduction). Particularly, because the authors finish the former with the message of the Β islet destruction and in the second paragraph of th eintroduction they explain adequately how this challenge can be surpassed. Section 3: Defects of current T1DM treatment I think it would be interesting if the authors referenced in the second paragraph reviews on a) selection of encapsulation materials and transplantation site, b)improve immune regulation and c) blood vessel formation Moreover, since the following sections focus significantly on key transcription factors for stem cell differentiation, the authors could have made a more compelling case about their importance in this paragraph. ANother key point I would like to address is that I always find interesting the 'prevent autoimmune destruction' concept, since in many cases, the damage is irreversible at the time of diagnosis. Therefore, the authors should have addressed here, providing more literature, the two other options, which are induced regeneration from MSCs or their differentiation to Β-islet. Despite the focus on the latter in the following sections, if this contrast would have been explicitly explained and contrasted at this point, the readers would assimilate easier the greater image of the clinical bottlenecks of possible T1DM treatments. Section 4: Maturation process of Β cells in vivo This chapter feels a bit misleading from the title, since it mostly focuses on the islet development steps during the embryonic development, in mice or humans. Plus, many aspects of this paragraph are informative, yet do not correlate significantly with the follow-up section, of how the maturaiton actually occurs. Thus, most of the points raised in this paragraph can be overlooked and forgotten from the reader, thus weakening the overall view on the paper. The most relevant aspect described is the MAF transcription factor and a few others which are introduced later, however the major aspect of the chapter is very introductory and based on the paper title, could be reduced. Section 5: Key markers in the process of β-cell maturation This part was very detailed and elaborate, with lots of evidence and body of work done previously, which do not come by as superficial information. What could have made the whole paragraph to read, would have been to split it in at least two or three subsections, underlying a wider message across each, since it comprises of numeorus factors that affect β cell maturation Section 6: Induction of β cells in vitro and current problems This is also a very well-written paragraph touching upon many crucial prerequisites in testing methods to produce effectively β cells, such as prolonged and sustainable insulin release, autocrine regulation of Β cells by other pancreatic islet cell types, culture techniques based on nutrition, maturation, and TF delivery. " 
Sun ZY, Yu TY, Jiang FX, Wang W. Functional maturation of immature β cells: A roadblock for stem cell therapy for type 1 diabetes. World J Stem Cells 2021; 13(3): 193-207 [PMID: 33815669 DOI: 10.4252/wjsc.v13.i3.193]
23
"Malignant melanoma most often occurs in the skin. Intraspinal malignant melanoma is quite rare. It is mainly distributed in the cervical segment, followed by the thoracic segment and thoracolumbar junction segment. This study analyzed and discussed the clinical, pathological, imaging data and treatment of this case of lumbar melanoma. The MRI features of melanoma vary with the proportion of melanocytes in the tumor.The diagnosis of this disease depends on puncture or surgical pathology.Because malignant melanoma in spinal canal is very rare, and its imaging manifestations are variable, it mainly needs to be differentiated from schwannoma and meningioma in spinal canal. In addition, hemorrhagic malignant melanoma should be differentiated from epidural hematoma and lipoma. For other rare intramedullary spinal cord tumors in this group, careful separation along the tumor interface is also required during microsurgical resection.However, it is often difficult to completely remove the tumor during the operation. The use of high-power microscope and ultrasonic scalpel is helpful to completely remove the tumor, and greatly improves the safety of the operation.For high-grade malignant tumors, excessive resection should not be pursued when the peritumoral interface is unclear. Postoperative radiotherapy or targeted therapy or immunotherapy based on gene detection can be considered to prolong the disease-free survival or overall survival rate. Neurophysiological monitoring and intraoperative ultrasound accurate positioning have become one of the routine intraoperative auxiliary means in neurosurgery. It is of great significance to guide accurate tumor resection, avoid spinal cord injury and improve postoperative neurological function." 
Li XJ, Yang L, Yan XF, Zhan CT, Liu JH. Granulomatosis with polyangiitis presenting as high fever with diffuse alveolar hemorrhage and otitis media: A case report. World J Clin Cases 2021; 9(10): 2344-2351 [DOI: 10.12998/wjcc.v9.i10.2344]
24
"a well-done review" 
Marques HS, Araújo GRL, da Silva FAF, de Brito BB, Versiani PVD, Caires JS, Milet TC, de Melo FF. Tertiary peritonitis: A disease that should not be ignored. World J Clin Cases 2021; 9(10): 2160-2169 [DOI: 10.12998/wjcc.v9.i10.2160]
25
"Was a family history of gastric cancer part of the exclusion criteria? can you conclude on the best candidates for additionnal surgery " 
Zheng Z, Bu FD, Chen H, Yin J, Xu R, Cai J, Zhang J, Yao HW, Zhang ZT. Factors associated with overall survival in early gastric cancer patients who underwent additional surgery after endoscopic submucosal dissection. World J Clin Cases 2021; 9(10): 2192-2204 [DOI: 10.12998/wjcc.v9.i10.2192]
26
"you mentioned a questionnaire intended for patients before the colonoscopy without detailing it the 1st paragraph of the statistical analysis part describes responses definitions not the statistical analysis" 
Zhang H, Liu J, Ma SL, Huang ML, Fan Y, Song M, Yang J, Zhang XX, Song QL, Gong J, Huang PX, Zhang H. Impact of simethicone on bowel cleansing during colonoscopy in Chinese patients. World J Clin Cases 2021; 9(10): 2238-2246 [DOI: 10.12998/wjcc.v9.i10.2238]
27
"There is repeated data in the clinical presentation Have you performed endoscopic checks and follow-up imaging Details of histological examinations should be described in the clinical presentation section. Is there an interest in performing a systematic endoscopy in order to make the diagnosis of gastric cancer at an early stage and Can you propose a monitoring algorithm for these patients including CA19-9, imaging and endoscopy?" 
Ma YH, Yamaguchi T, Yasumura T, Kuno T, Kobayashi S, Yoshida T, Ishida T, Ishida Y, Takaoka S, Fan JL, Enomoto N. Pancreatic cancer secondary to intraductal papillary mucinous neoplasm with collision between gastric cancer and B-cell lymphoma: A case report. World J Clin Cases 2021; 9(10): 2400-2408 [DOI: 10.12998/wjcc.v9.i10.2400]
28
"I would like to thank the editorial board for the excellent summary of the activities of the journal. I would like to suggest one point; as board member I am having trouble in receiving communicatory mail from the journal website. Therefore, I have missed a review request. Could there be anything done about it?" 
Ma L, Li X. Meeting report of the editorial board meeting for World Journal of Hepatology 2021. World J Hepatol 2021; 13(2): 162-165 [PMID: 33708348 DOI: 10.4254/wjh.v13.i2.162]
29
"It's a great report. Are you sure if the waterfall sign will appear in other similar patient? In my opinion, I agree to explore this sign in advanced" 
Xing ZX, Yang H, Zhang W, Wang Y, Wang CS, Chen T, Chen HJ. Point-of-care ultrasound for the early diagnosis of emphysematous pyelonephritis: A case report and literature review . World J Clin Cases 2021; 9(11): 2584-2594 [DOI: 10.12998/wjcc.v9.i11.2584]
30
"1. The authors may use tables for further illustrating of "CPSP treatments", and "CPSP prevention". Adding tables will let readers more systemically and comprehensively understanding methods of CPSP treatment & prevention. 2. In introduction part, about the epidemiology, incidence of CPSP, the authors should illustrate more. 3. In a review paper published in 2018 [Thaba B, 2018 Jul;31(3):155-173.] , Thaba B et al. detailedly listed the prevention and managments of CPSP. Thus, the authors of this paper (Yi-Ming Liu et al.) should listed the new finding about the prevention and managments of CPSP during 2018-2021." 
Liu YM, Feng Y, Liu YQ, Lv Y, Xiong YC, Ma K, Zhang XW, Liu JF, Jin Y, Bao HG, Yan M, Song T, Liu Q. Chinese Association for the Study of Pain: Expert consensus on chronic postsurgical pain. World J Clin Cases 2021; 9(9): 2090-2099 [PMID: 33850928 DOI: 10.12998/wjcc.v9.i9.2090]
31
"1. The authors may use tables for further illustrating of "CPSP treatments", and "CPSP prevention". Adding tables will let readers more systemically and comprehensively understanding methods of CPSP treatment & prevention. 2. In introduction part, about the epidemiology, incidence of CPSP, the authors should illustrate more. 3. In a review paper published in 2018 [Thaba B, 2018 Jul;31(3):155-173.] , Thaba B et al. detailedly listed the prevention and managments of CPSP. Thus, the authors of this paper (Yi-Ming Liu et al.) should listed the new finding about the prevention and managments of CPSP during 2018-2021. " 
Huang D, Liu YQ, Xia LJ, Liu XG, Ma K, Liu GZ, Xiao LZ, Song T, Yang XQ, Fu ZJ, Yan M. Expert consensus of Chinese Association for the Study of Pain on the non-opioid analgesics for chronic musculoskeletal pain. World J Clin Cases 2021; 9(9): 2068-2076 [PMID: 33850926 DOI: 10.12998/wjcc.v9.i9.2068]
32
"As the authors emphasize, the limitation of this study is that it is essentially a retrospective and single-center study. However, the determination that male gender, T1b invasion, high-grade tumor, lymph node metastasis, and residual tumor are independently associated with OS in ECG cases in this study also reveals valuable parameters that need to be examined in future studies." 
Zheng Z, Bu FD, Chen H, Yin J, Xu R, Cai J, Zhang J, Yao HW, Zhang ZT. Factors associated with overall survival in early gastric cancer patients who underwent additional surgery after endoscopic submucosal dissection. World J Clin Cases 2021; 9(10): 2192-2204 [DOI: 10.12998/wjcc.v9.i10.2192]
33
"This study is presented to increase the limited knowledge about intrabdominal neurogenic tumors." 
Simsek C, Uner M, Ozkara F, Akman O, Akyol A, Kav T, Sokmensuer C, Gedikoglu G. Comprehensive clinicopathologic characteristics of intraabdominal neurogenic tumors: Single institution experience. World J Clin Cases 2021; 9(10): 2218-2227 [DOI: 10.12998/wjcc.v9.i10.2218]
34
"In this study, results emphasizing the geographical differences in the application of PEG and simethicone were obtained. In Chinese patients, it was concluded that the addition of Simethicone to PEG is not only effective in detecting neplastic lesions in the proximal colon, but also safe to use." 
Zhang H, Liu J, Ma SL, Huang ML, Fan Y, Song M, Yang J, Zhang XX, Song QL, Gong J, Huang PX, Zhang H. Impact of simethicone on bowel cleansing during colonoscopy in Chinese patients. World J Clin Cases 2021; 9(10): 2238-2246 [DOI: 10.12998/wjcc.v9.i10.2238]
35
"The case presented here supports that the findings that PD-1 inhibitors are effective in the therapy of soft tissue sarcomas, especially in alveolar soft part sarcoma and undifferentiated sarcoma. The latest can also be observed in the liver. During the pathological examination, determining the PD-1 expression of these tumors may be a valuable guide for treatment." 
Yu XH, Huang J, Ge NJ, Yang YF, Zhao JY. Recurrent undifferentiated embryonal sarcoma of the liver in adult patient treated by pembrolizumab: A case report. World J Clin Cases 2021; 9(10): 2281-2288 [DOI: 10.12998/wjcc.v9.i10.2281]
36
"LAMN is among the tumor groups that can cause problems both in the clinical and pathological differential diagnosis. Indeed, clinical findings may sometimes be needed during pathological evaluation for accurate diagnosis. The case presented here clearly highlights the importance of imaging features of such lesions and should be taken into account in the evaluation." 
Borges AL, Reis-de-Carvalho C, Chorão M, Pereira H, Djokovic D. Low-grade mucinous appendiceal neoplasm mimicking an ovarian lesion: A case report and review of literature. World J Clin Cases 2021; 9(10): 2334-2343 [DOI: 10.12998/wjcc.v9.i10.2334]
37
"this is a multistudy ananlysis that reports various studies results performed on HCV gentype 3. Great appreciable effort was to gathers data. however some of subtitles were not reflecting the contents as i expected. generally, HCV presents a public health problem worldwide, which further requires extensive study due to mutant forms and subtypes appearing with time. e.g HCV genotype 3 has further six sub- genotypes, it emerged as one of most difficult HCV genotypes to treatment regimens, conspicuously due to presence of presence of resistance-associated substations (RASs) in the viral sequence as Y93H substitution which contributs to lower SVR rates, especially in patients with cirrhosis. Also, several factors influence the choice and duration of therapy as presence of cirrhosis, and stage of liver disease, drug interactions, coexistent kidney disease and if patient received previous treatment regimen. It is also worth noting that clinical data for treatment-experienced individuals with genotype 3 is limited for glecaprevir-pibrentasvir." 
Zarębska-Michaluk D. Genotype 3-hepatitis C virus’ last line of defense. World J Gastroenterol 2021; 27(11): 1006-1021 [PMID: 33776369 DOI: 10.3748/wjg.v27.i11.1006]
38
"As the authors point out, immune checkpoints can be used in therapy beyond just having a critical role in the immune system function. The case presented here also suggests a treatment option of CAR-T cell and a PD-1 inhibitor for relapsing and refractory non-Hodgkin lymphoma." 
Niu ZY, Sun L, Wen SP, Song ZR, Xing L, Wang Y, Li JQ, Zhang XJ, Wang FX. Programmed cell death protein-1 inhibitor combined with chimeric antigen receptor T cells in the treatment of relapsed refractory non-Hodgkin lymphoma: A case report. World J Clin Cases 2021; 9(10): 2394-2399 [DOI: 10.12998/wjcc.v9.i10.2394]
39
"This case report provides comprehensive information on the diagnosis and treatment of collision tumors. However, it would be more interesting if the demographic findings of lymphomas detected with pancreatic and stomach cancers were given as a table." 
Ma YH, Yamaguchi T, Yasumura T, Kuno T, Kobayashi S, Yoshida T, Ishida T, Ishida Y, Takaoka S, Fan JL, Enomoto N. Pancreatic cancer secondary to intraductal papillary mucinous neoplasm with collision between gastric cancer and B-cell lymphoma: A case report. World J Clin Cases 2021; 9(10): 2400-2408 [DOI: 10.12998/wjcc.v9.i10.2400]
40
"This case reveals that although I have encountered patients with malignancy with unusual bleeding patterns, as the authors emphasize, AH, a condition ‘’I have never seen before’’, can be observed in bile duct carcinoma. However, if only comprehensive information could be provided in terms of other tumors in which AH is present." 
Krašek V, Kotnik A, Zavrtanik H, Klen J, Zver S. Acquired haemophilia in patients with malignant disease: A case report. World J Clin Cases 2021; 9(10): 2409-2418 [DOI: 10.12998/wjcc.v9.i10.2409]
41
"This article had shown us the key characteristics of white endoscopy of the sessile serrated lesions. It is a significant mention for the endoscopists. However, combining the pigment endoscopy, it may be a better method to differentiate the sessile serrated lesions with others such as adenomatous polyps. Another point is that comparison with other lesions may be a good method to identify the key characteristics of the sessile serrated lesions." 
Nishizawa T, Yoshida S, Toyoshima A, Yamada T, Sakaguchi Y, Irako T, Ebinuma H, Kanai T, Koike K, Toyoshima O. Endoscopic diagnosis for colorectal sessile serrated lesions. World J Gastroenterol 2021; 27(13): 1321-1329 [PMID: 33833485 DOI: 10.3748/wjg.v27.i13.1321]
42
"This study is very important on the impact of perioperative blood transfusion for outcomes in PLDLT. There are few reports of these kinds on young patients, and this study is excellent including both short and long-term outcomes. I could understand the negative effect of perioperative blood transfusion, but in this type of study, it remains a question whether blood transfusions are always bad or whether it is bad to have a condition that requires blood transfusions. To clarify this issue, it seems necessary to equal the amount of blood loss and compare these cases with and without blood transfusion, if possible. " 
Gordon K, Figueira ERR, Rocha-Filho JA, Mondadori LA, Joaquim EHG, Seda-Neto J, da Fonseca EA, Pugliese RPS, Vintimilla AM, Auler Jr JOC, Carmona MJC, D'Alburquerque LAC. Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation. World J Gastroenterol 2021; 27(12): 1161-1181 [PMID: 33828392 DOI: 10.3748/wjg.v27.i12.1161]
43
"Fatigue has a subjective nature which makes it very difficult to measure. However, this study is carried on fairly a large number of patients with different age groups, education varieties. I would like to add that fatigue may result from medication adverse effect and it may point to presence of complications from active disease. I think female or males experience fatigue similarly Another important risk factor for fatigue which require significant attention is micronutrient deficiency as result of malabsorption, diarrhea, dietary constrictions. For example, gluten-free diet may be poor in minerals and vitamins as calcium, iron, niacin, and thiamine. " 
Gong SS, Fan YH, Lv B, Zhang MQ, Xu Y, Zhao J. Fatigue in patients with inflammatory bowel disease in Eastern China. World J Gastroenterol 2021; 27(11): 1076-1089 [PMID: 33776374 DOI: 10.3748/wjg.v27.i11.1076]
44
"The current paper is a very interesting case report that describes the Three-dimensional-printed custom-made patellar endoprosthesis, 3D printing is now becoming more and more available for difficult cases like this. The paper has some clinical value and can be a reference for the future. " 
Wang J, Zhou Y, Wang YT, Min L, Zhang YQ, Lu MX, Tang F, Luo Y, Zhang YH, Zhang XL, Tu CQ. Three-dimensional-printed custom-made patellar endoprosthesis for recurrent giant cell tumor of the patella: A case report and review of the literature. World J Clin Cases 2021; 9(11): 2524-2532 [DOI: 10.12998/wjcc.v9.i11.2524]
45
"This paper is a study to analyze the coronavirus disease 2019 (COVID-19) mortality of patients diagnosed with inflammatory bowel disease (IBD) in Brazil according to the risk of developing COVID-19 or its complications, and see what differences there are in the geographical distribution. There seems to be no mention of how many IBD patients were confirmed for COVID-19 and what their prognosis was in the paper. Although it was mentioned as the limitation of the study in the discussion, there was no analysis based on the differences in IBD activity, and there are insufficient results on whether patients continued the IBD medication when infected with COVID-19. However, it seems to be a meaningful study to see the nationwide distribution of IBD patients and the mortality rates of COVID-19. " 
Queiroz NSF, Teixeira FV, Motta MP, Chebli LA, Hino AAF, Martins CA, Quaresma AB, Silva AAPD, Damião AOMC, Saad-Hossne R, Kotze PG. Risk stratification and geographical mapping of Brazilian inflammatory bowel disease patients during the COVID-19 outbreak: Results from a nationwide survey. World J Gastroenterol 2021; 27(12): 1226-1239 [PMID: 33828396 DOI: 10.3748/wjg.v27.i12.1226]
46
"In this review, very comprehensive information about gastric amyloidosis, which is rarely seen but whose differential diagnosis is challenging, is presented with good illustrations." 
Lin XY, Pan D, Sang LX, Chang B. Primary localized gastric amyloidosis: A scoping review of the literature from clinical presentations to prognosis . World J Gastroenterol 2021; 27(12): 1132-1148 [PMID: 33828390 DOI: 10.3748/wjg.v27.i12.1132]
47
"The prevalence of symptomatic obstructive sleep apnea in western countries is not low, ranging from 2%-4%. The condition is associated with oxygen desaturations and arousals from sleep, which can lead to increased blood pressure (BP) and high risk of cardiovascular disease. Previous researches have confirmed that both continuous positive airway pressure therapy (CPAP) and mandibular advancement devices (MADs) were associated with reductions in blood pressure. However, as noted by the author, compliance with CPAP is poor and there is a risk that the underlying condition may worsen in the long-term in patients using MADs. Thus, this is an interesting case and providing a promising method to treat OSA. I hope this would be widely used in clinic." 
Singh GD, Kherani S. Changes in sleep parameters following biomimetic oral appliance therapy: A case report. World J Clin Cases 2021; 9(10): 2312-2319 [DOI: 10.12998/wjcc.v9.i10.2312]
48
"Interesting topic, worth to read" 
Khalil MI, Banik GR, Mansoor S, Alqahtani AS, Rashid H. SARS-CoV-2, surgeons and surgical masks. World J Clin Cases 2021; 9(10): 2170-2180 [DOI: 10.12998/wjcc.v9.i10.2170]
49
"This was a very interesting, engaging and concrete case report, highlighting the diagnostic radiological imaging challenges of appendiceal neoplasms and adnexal lesions. The article was very well visualized. The main differences between LAMN and ovarian cancer imaging modalities were discussed. This article also pointed out the importance of multidisciplinary communication. The authors performed the literature search of accompanying cases which added more scientific quality to this case. The authors concluded that registering such cases and reviewing the preoperative imaging findings may increase preoperative diagnostic sensitivity and specificity, which I think is worth considering but hard to apply in daily clinical practice. What could have been improved? The needed follow-up of the patient could have been added. Is the follow-up required after appendectomy in such cases? What are the optimal imaging modalities and intervals for a follow-up? Is there any risk of disease renewal? " 
Borges AL, Reis-de-Carvalho C, Chorão M, Pereira H, Djokovic D. Low-grade mucinous appendiceal neoplasm mimicking an ovarian lesion: A case report and review of literature. World J Clin Cases 2021; 9(10): 2334-2343 [DOI: 10.12998/wjcc.v9.i10.2334]
50
"This is an interesting review that aimed to discuss the HCV impact on health care outcomes for patients of all ages. Overall, the manuscript is very well written and discuss various interesting aspects related to the topic. The role of new DAA antiviral drugs is thoroughly reviewed, with a good side to mention its impact on liver transplantation. Despite, the author forgot to mention either drug interaction with immuno-suppressant nor role of extrahepatic reservoir that proposed to play a role in HCV reinfection. Of note, the paragraph on HCV and coronavirus grabbed my attention and it shades a light on the next future for HCV and HCC patients. At all, I would recommend this review to the scientific community." 
Rogers ME, Balistreri WF. Cascade of care for children and adolescents with chronic hepatitis C. World J Gastroenterol 2021; 27(12): 1117-1131 [PMID: 33828389 DOI: 10.3748/wjg.v27.i12.1117]
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