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Reader Comments
Publication Name
Article Title
Year Published
1
"Interesting topic but author should include biomechanical or patient data to consolidate his findings and conclusions." 
Nandi S. Revisiting Pauwels' classification of femoral neck fractures. World J Orthop 2021; 12(11): 811-815 [DOI: 10.5312/wjo.v12.i11.811]
2
"As the author mentions in discussion, further study is needed to determine the selection criteria for staging laparoscopy. " 
Hashimoto Y, Ajiki T, Yanagimoto H, Tsugawa D, Shinozaki K, Toyama H, Kido M, Fukumoto T. Risk factors for occult metastasis detected by inflammation-based prognostic scores and tumor markers in biliary tract cancer. World J Clin Cases 2021; 9(32): 9770-9782 [DOI: 10.12998/wjcc.v9.i32.9770]
3
"This article summarized the various treatment for depression and explained each advantages and disadvantages, especially table 1 and fogure1 were very useful for clinicians. If possible. it is more useful if the author made the table or figure about the somatic treatment ." 
Karrouri R, Hammani Z, Benjelloun R, Otheman Y. Major depressive disorder: Validated treatments and future challenges. World J Clin Cases 2021; 9(31): 9350-9367 [DOI: 10.12998/wjcc.v9.i31.9350]
4
"The authors present an excellent minireview highlighting the role of imaging on work-up of patients candidates for pancreatic head resection for pancreatic cancer, specifically the radiologic evaluation of mesopancreas for surgical planning, a critical region for locoregional recurrence after resection, therefore it impacts on prognosis of patients." 
Feng P, Cheng B, Wang ZD, Liu JG, Fan W, Liu H, Qi CY, Pan JJ. Application and progress of medical imaging in total mesopancreas excision for pancreatic head carcinoma. World J Gastrointest Surg 2021; 13(11): 1315-1326 [DOI: 10.4240/wjgs.v13.i11.1315]
5
"Not so hot topic, but interesting contents." 
Patel A, Spychalski P, Antoszewska M, Regula J, Kobiela J. Proton pump inhibitors and colorectal cancer: A systematic review. World J Gastroenterol 2021; 27(44): 7716-7733 [DOI: 10.3748/wjg.v27.i44.7716]
6
"This is an interesting study. It would be good to had been reported the status of renal function, because these patients usually present a rate of renal disease, which is combined with an additional risk of bleeding, since thrombocytopenia and thrombopathy are common characteristis of renal disease." 
Ostojic Z, Ostojic A, Bulum J, Mrzljak A. Safety and efficacy of dual antiplatelet therapy after percutaneous coronary interventions in patients with end-stage liver disease. World J Cardiol 2021; 13(11): 599-607 [DOI: 10.4330/wjc.v13.i11.599]
7
"It is an interesting article on the link between alcohol consumption and viral hepatitis. It would have been good to have further explained the association with alcohol metabolites." 
Xu HQ, Wang CG, Zhou Q, Gao YH. Effects of alcohol consumption on viral hepatitis B and C. World J Clin Cases 2021; 9(33): 10052-10063 [DOI: 10.12998/wjcc.v9.i33.10052]
8
"The article raises the awareness that the possibility of malignancy even for small lesions in the colon should be considered." 
Takashina Y, Kudo SE, Ichimasa K, Kouyama Y, Mochizuki K, Akimoto Y, Maeda Y, Mori Y, Misawa M, Ogata N, Kudo T, Hisayuki T, Hayashi T, Wakamura K, Sawada N, Baba T, Ishida F, Yokoyama K, Daita M, Nemoto T, Miyachi H. Clinicopathological features of small T1 colorectal cancers. World J Clin Cases 2021; 9(33): 10088-10097 [DOI: 10.12998/wjcc.v9.i33.10088]
9
"It is an interesting article on the link between alcohol consumption and viral hepatitis. It would have been good to have further explained the association with alcohol metabolites." 
Xu HQ, Wang CG, Zhou Q, Gao YH. Effects of alcohol consumption on viral hepatitis B and C. World J Clin Cases 2021; 9(33): 10052-10063 [DOI: 10.12998/wjcc.v9.i33.10052]
10
"For postoperative elderly gastric cancer patients, good nutrition may minimize postoperative complications, especially in patients with gastric cancer after total gastrectomy. Of course, laparoscopic surgery has advantages over open surgery. In our center, nasal jejunal nutrition tube will be routinely placed in elderly gastric cancer patients after operation, and this measure has greatly promoted the postoperative recovery of elderly gastric cancer patients. This article does not mention the application of nasal jejunal nutrition tube, I think the application of nasal jejunal nutrition tube should be properly advocated for postoperative elderly gastric cancer patients." 
Kawaguchi Y, Akaike H, Shoda K, Furuya S, Hosomura N, Amemiya H, Kawaida H, Kono H, Ichikawa D. Is surgery the best treatment for elderly gastric cancer patients? World J Gastrointest Surg 2021; 13(11): 1351-1360 [DOI: 10.4240/wjgs.v13.i11.1351]
11
"The study is very useful in highlighting the potential of Dual antiplatelet therapy (DAPT), a standard of care after percutaneous coronary intervention (PCI). It is also interesting to observe complementary medical therapy, such as proton pump inhibitors and beta-blockers, to be prescribed for lower bleeding risk patients. In this case, thromboelastography and “preventive” upper endoscopies in PCI circumstances which are somewhat novel approaches, is required for clinical confirmation. " 
Ostojic Z, Ostojic A, Bulum J, Mrzljak A. Safety and efficacy of dual antiplatelet therapy after percutaneous coronary interventions in patients with end-stage liver disease. World J Cardiol 2021; 13(11): 599-607 [DOI: 10.4330/wjc.v13.i11.599]
12
"The relationship between COVID-19 and acute appendicitis is an interesting topic." 
Teng TZJ, Thong XR, Lau KY, Balasubramaniam S, Shelat VG. Acute appendicitis–advances and controversies. World J Gastrointest Surg 2021; 13(11): 1293-1314 [DOI: 10.4240/wjgs.v13.i11.1293]
13
"This a minireview of the potencial methods for optimizing FLR before liver resection. The objetives for elucidating the crucial aspects of the subject are achieved, moreover the article is clear and concise, highlighting the main procedures of FLR hypertrophy according to the current literature. Very good article. " 
Del Basso C, Gaillard M, Lainas P, Zervaki S, Perlemuter G, Chagué P, Rocher L, Voican CS, Dagher I, Tranchart H. Current strategies to induce liver remnant hypertrophy before major liver resection. World J Hepatol 2021; 13(11): 1629-1641 [DOI: 10.4254/wjh.v13.i11.1629]
14
"In this review article, Hsiao et.al. summarized the current advancement in the use of 3D technology to differentiate dental pulp stem cells. The application of 3D conditions has been successfully used in stem cells isolated different sources including human embryonic stem cells (hESCs) and the induced pluripotent stem cells (iPSCs). 3D-mediated stem cells differentiation creates a microenvironment that mimics the in vivo situation, improves cell-cell contact, and enhances cell signaling." 
Hsiao HY, Nien CY, Hong HH, Cheng MH, Yen TH. Application of dental stem cells in three-dimensional tissue regeneration. World J Stem Cells 2021; 13(11): 1610-1624 [DOI: 10.4252/wjsc.v13.i11.1610]
15
"Well documented. But, There is no information about the Omentum/Bursectomy. It would have been more meaningful if there was a part about omentectomy." 
Bausys A, Gricius Z, Aniukstyte L, Luksta M, Bickaite K, Bausys R, Strupas K. Current treatment strategies for patients with only peritoneal cytology positive stage IV gastric cancer. World J Clin Cases 2021; 9(32): 9711-9721 [DOI: 10.12998/wjcc.v9.i32.9711]
16
"The study on cancer immunity in terms of dendritic cells is very important." 
Kwiecień I, Rutkowska E, Raniszewska A, Rzepecki P, Domagała-Kulawik J. Modulation of the immune response by heterogeneous monocytes and dendritic cells in lung cancer. World J Clin Oncol 2021; 12(11): 966-982 [DOI: 10.5306/wjco.v12.i11.966]
17
"This is a timely review that addresses an issue for which information is rapidly evolving. The authors point to several models that may permit avoidance of the need to continue surveillance of hepatocellular carcinoma in selected patients after hepatitis C cure. Although promising, longer term studies are needed to validate the utility of the proposed strategies." 
Ahumada A, Rayón L, Usón C, Bañares R, Alonso Lopez S. Hepatocellular carcinoma risk after viral response in hepatitis C virus-advanced fibrosis: Who to screen and for how long? World J Gastroenterol 2021; 27(40): 6737-6749 [PMID: 34790004 DOI: 10.3748/wjg.v27.i40.6737]
18
"This is a timely review that highlights barriers and opportunities for improving hepatocellular carcinoma (HCC) surveillance in high risk groups. A a minor comment, although leading professional societies endorse HCC surveillance in these populations, this view is not shared by the United States National Cancer Institute." 
Del Poggio P, Mazzoleni M, Lazzaroni S, D'Alessio A. Surveillance for hepatocellular carcinoma at the community level: Easier said than done. World J Gastroenterol 2021; 27(37): 6180-6190 [PMID: 34712026 DOI: 10.3748/wjg.v27.i37.6180]
19
"This is a retrospective study reinforces the crucial role of staging laparoscopy in BTC surgery, thereforereducing the rate of useless exploratory laparotomy." 
Hashimoto Y, Ajiki T, Yanagimoto H, Tsugawa D, Shinozaki K, Toyama H, Kido M, Fukumoto T. Risk factors for occult metastasis detected by inflammation-based prognostic scores and tumor markers in biliary tract cancer. World J Clin Cases 2021; 9(32): 9770-9782 [DOI: 10.12998/wjcc.v9.i32.9770]
20
"Pazopanib is a well-known but recently used drug extensively in renal neoplasms and these data are very useful for all readers who are interested in uro oncology" 
Buti S, Bersanelli M, Massari F, De Giorgi U, Caffo O, Aurilio G, Basso U, Carteni G, Caserta C, Galli L, Boccardo F, Procopio G, Facchini G, Fornarini G, Berruti A, Fea E, Naglieri E, Petrelli F, Iacovelli R, Porta C, Mosca A. First-line pazopanib in patients with advanced non-clear cell renal carcinoma: An Italian case series. World J Clin Oncol 2021; 12(11): 1037-1046 [DOI: 10.5306/wjco.v12.i11.1037]
21
"This review summarizes the current knowledge on how the gut microbiota and microbially-derived compounds affect host metabolism, especially in the context of obesity and related disorders. The overall quality of the manuscript is excellent with a very good quality of english language " 
Barone M, D'Amico F, Fabbrini M, Rampelli S, Brigidi P, Turroni S. Over-feeding the gut microbiome: A scoping review on health implications and therapeutic perspectives. World J Gastroenterol 2021; 27(41): 7041-7064 [DOI: 10.3748/wjg.v27.i41.7041]
22
"This article discusses the main limitations in the development of new drugs and potential future scenarios. In particular, the authors addressed three questions: (1) The main limitations of targeted therapy in the treatment of metastatic CRC (mCRC); (2) New target armamentarium that could escape primary and secondary resistance and lead to more personalized mCRC therapy; and (3) Future directions. The quality of the manuscript is grade B (very good)" 
Cherri S, Libertini M, Zaniboni A. New drugs for the treatment of metastatic colorectal cancer. World J Gastrointest Oncol 2021; 13(11): 1551-1560 [PMID: 34853636 DOI: 10.4251/wjgo.v13.i11.1551]
23
"This manuscript is creation of Inflammation-based prognostic scores and tumor markers, and found that are useful in detecting occult metastasis in BTC. They concluded that based on these factors, staging laparoscopy may reduce the rate of EL. It was a useful tool that help surgeon to choose the suitable operation method and find a right way in the surgery progress. With the evaluation of multicenter RCT, it may be more convinced. They should figure out the location of the patients with metastasis and assess the factor of tumor location in the progress of metastasis in abdominal disseminations. And the ALBI may be more suitable than Glasgow to evaluate the prognosis. " 
Hashimoto Y, Ajiki T, Yanagimoto H, Tsugawa D, Shinozaki K, Toyama H, Kido M, Fukumoto T. Risk factors for occult metastasis detected by inflammation-based prognostic scores and tumor markers in biliary tract cancer. World J Clin Cases 2021; 9(32): 9770-9782 [DOI: 10.12998/wjcc.v9.i32.9770]
24
" This is a well-written and presented rare case report .This manuscript gives additional new knowledge to the existing literatüre. I think that this manuscript is worth to publication. " 
Nguyen LC, Vu KT, Vo TTT, Trinh CH, Do TD, Pham NTV, Pham TV, Nguyen TT, Nguyen HC, Byeon JS. Brunner’s gland hyperplasia associated with lipomatous pseudohypertrophy of the pancreas presenting with gastrointestinal bleeding: A case report. World J Clin Cases 2021; 9(31): 9670-9679 [DOI: 10.12998/wjcc.v9.i31.9670]
25
"Reader could not understand the association between risk factor of occult metastasis and Staging laparoscopy, which means that their title has no correspondence with their conclusions. " 
Hashimoto Y, Ajiki T, Yanagimoto H, Tsugawa D, Shinozaki K, Toyama H, Kido M, Fukumoto T. Risk factors for occult metastasis detected by inflammation-based prognostic scores and tumor markers in biliary tract cancer. World J Clin Cases 2021; 9(32): 9770-9782 [DOI: 10.12998/wjcc.v9.i32.9770]
26
"This minireview highligths an updated general revision of the multi-disciplinary approach unresectable HC, including surgery, medical oncology, radiation oncology, diagnostic radiology, interventional radiology, gastroenterology, and pathology. The main conclusions lies in the achievement of overall survival, response rates, and tumor control with the combination of chemotherapy and minimal invasive ablatives strategies." 
Inchingolo R, Acquafredda F, Ferraro V, Laera L, Surico G, Surgo A, Fiorentino A, Marini S, de'Angelis N, Memeo R, Spiliopoulos S. Non-surgical treatment of hilar cholangiocarcinoma. World J Gastrointest Oncol 2021; 13(11): 1696-1708 [PMID: 34853644 DOI: 10.4251/wjgo.v13.i11.1696]
27
"Cirrhosis is closely associated with an enrichment of non-classical CD14+CD16+ monocyte-derived macrophages. It is highly potential that macrophages with this property may be a major diagnostic marker for cirrhosis." 
García-Peñarrubia P, Ruiz-Alcaraz AJ, Ruiz-Ballester M, Ramírez-Pávez TN, Martínez-Esparza M. Recent insights into the characteristics and role of peritoneal macrophages from ascites of cirrhotic patients. World J Gastroenterol 2021; 27(41): 7014-7024 [DOI: 10.3748/wjg.v27.i41.7014]
28
"I like the novel perspective of this article. It reminded us to focus on the patients with co-infection of chronic hepatitis C with and without cirrhosis and COVID-19. Male gender, diabetes mellitus, and liver cirrhosis were the independent factors affecting mortality in these patients. It may help the doctor to treat with such patients and improve the outcome of such patients. So it's very meaningful." 
Afify S, Eysa B, Hamid FA, Abo-Elazm OM, Edris MA, Maher R, Abdelhalim A, Abdel Ghaffar MM, Omran DA, Shousha HI. Survival and outcomes for co-infection of chronic hepatitis C with and without cirrhosis and COVID-19: A multicenter retrospective study. World J Gastroenterol 2021; 27(42): 7362-7375 [DOI: 10.3748/wjg.v27.i42.7362]
29
" Multimodal treatments of “gallstone cholangiopancreatitis” Vanella S., MD¹; Baiamonte F., MD², Crafa F., MD ¹ 1. General and Oncological Surgery Unit, Hospital of National Relevance and High Specialty “St. Giuseppe Moscati”, Avellino – Italy 2. General and Emergency Surgery 1 Unit, Civico Hospital, Palermo, Italy We have read your article with great attention and interest. Congratulations on the article, the definition of “gallstone cholangiopancreatitis”, the etiological and prognostic hypotheses. However, it seems appropriate to report some comments. It is difficult to distinguish with alanine aminotransferase alone whether it is cholangitis associated with gallstone pancreatitis or an onset of multiorgan failure or other concomitant liver disease. [1] Anyhow, your reflections pave the way for future studies to find methods to better define cholangiopancreatitis from other liver diseases that can compromise the course of this pathology. Furthermore, even if your article was not intended to deal with all management strategies, it seems appropriate to make some clarifications here too. Gallstone pancreatitis associated with cholangitis requires urgent biliary decompression to ameliorate the disease course. The possibilities of biliary decompression are many, not only endoscopic retrograde cholangiopancreatography (ERCP), and depend on the clinical status of the patient, on the size of the stones, on any previous bilio-digestive derivations. Guidelines recommend urgent ERCP in patients with gallstone pancreatitis with concomitant cholangitis and suggest that ERCP might be beneficial in patients with cholestasis but without cholangitis.[2-4] Schepers et al showed that the urgent ERCP + endoscopic sphynterotomy (ES) is indicated in patients with acute pancreatitis and cholangitis or persistent cholestasis. [5] The execution of an ERCP ensures excellent clearance of the VBP where, however, a certain percentage of patients require two or more treatments with ERCP. ERCP with sphincterotomy is an invasive procedure that is associated with complications in up to 10% of patients. [6,7] Local complications of ERCP include bleeding, duodenal perforation, cholangitis, pancreatitis, VBP lesions. Furthermore, in some cases the ERCP is not practicable. Previous trial suggested that ERCP was associated with increased respiratory complications.19 In severely ill patients these respiratory complications might be triggered by conscious sedation and potential aspiration or by temporarily reduced oxygenation associated with sedation. Schepers et al observed more intensive care admissions in the urgent ERCP group. [5] In our clinical practice we subject critically ill patients, who may not tolerate general anesthesia or deep sedation, to percutaneous placement of biliary drains as a first step with a possible attempt to clear the common bile duct also with the use of percutaneous cholangioscopy and laser. it is also clear that the postoperative management of a VBP drainage can present some complications such as displacement, obstruction, bacterial superinfection. At the same time, it offers the advantage of an easy cholangiographic check in the follow-up, useful for documenting the absence of residual stones and the patency of the biliary tract in its entirety. After stabilization of the clinical picture we proceed to surgery and ERCP with rendez-vous or if it is not possible to perform ERCP + ES, with laparoscopic CBD exploration (LCBDE). Aawsaj showed that laparoscopic bile duct exploration can be performed successfully in both the emergency and elective settings. A transcystic approach should be favoured where possible. [8] Cholecystectomy within the same admission might prevent recurrent gallstone pancreatitis. A previous Review showed no difference between open surgery versus ERCP in clearance, morbidity and mortality. In the open surgery group had significantly fewer retained stones compared with the ERCP group (6% vs 16%, p= 0.0002). Comparing LC + LCBDE versus two-staged pre-operative ERCP + LC or LC + post-operative ERCP There were fewer retained stones in the single-stage group (8%) compared with the two-stage group (14%) (p=ns). [9] In the study of Ding et al, at longer-term follow-up, recurrent CBD stones were seen more often in the two-stage group (9.5 vs. 2.1%, p = 0.037). [10] Endoscopic group had a significantly greater number of procedures per patient (p < 0.001) and a higher cost (p = 0.002). The two groups did not differ significantly in terms of major complications. [11] Balloon dilation is a valid alternative to endoscopic sphincterotomy, it can be performed both percutaneously and endoscopically, and compared to sphincterotomy it is simpler to perform, it is burdened by a lower percentage of bleeding and lesions of the sphincter of Oddi, but compared to sphincterotomy it is less effective in guaranteeing a correct clearance of VBP. In the era of multimodal treatments where endoscopic techniques offer significant diagnostic and therapeutic advantages for the treatment of common bile duct obstruction, laparoscopic treatment may represent the technique of choice in clinically stable patients with larger CBD, in patients with a history of previous bariatric surgery or other bilio-digestive derivations, and in patients in whom the endoscopic route has proved unsuccessful. In addition, the laparoscopic approach guarantees the possibility of performing only one anesthesia. The exploration by means of choledochoscopy of the main biliary tract and the simultaneous removal of the stones from the choledochus in a single stage (single-stage procedure), is an effective, safe and minimally invasive method in the treatment of gallstone cholangiopancreatitis, provided that it is performed in reference centers. and by operators with adequate experience. It also reduces the anesthetic risks associated with two subsequent procedures, reduces the average hospital stay and the costs of multiple hospitalizations. References 1. Brisinda G, Vanella S, Crocco A, Mazzari A, Tomaiuolo P, Santullo F, Grossi U, Crucitti A. Severe acute pancreatitis: advances and insights in assessment of severity and management. Eur J Gastroenterol Hepatol. 2011 Jul;23(7):541-51. doi: 10.1097/MEG.0b013e328346e21e. 2. Tenner S, Baillie J, DeWitt J, Vege SS; American College of Gastroenterology. American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol. 2013 Sep;108(9):1400-15; 1416. doi: 10.1038/ajg.2013.218. Epub 2013 Jul 30. Erratum in: Am J Gastroenterol. 2014 Feb;109(2):302. 3. Arvanitakis M, Dumonceau JM, Albert J, Badaoui A, Bali MA, Barthet M, Besselink M, Deviere J, Oliveira Ferreira A, Gyökeres T, Hritz I, Hucl T, Milashka M, Papanikolaou IS, Poley JW, Seewald S, Vanbiervliet G, van Lienden K, van Santvoort H, Voermans R, Delhaye M, van Hooft J. Endoscopic management of acute necrotizing pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) evidence-based multidisciplinary guidelines. Endoscopy. 2018 May;50(5):524-546. doi: 10.1055/a-0588-5365. Epub 2018 Apr 9. 4. Crockett SD, Wani S, Gardner TB, Falck-Ytter Y, Barkun AN; American Gastroenterological Association Institute Clinical Guidelines Committee. American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis. Gastroenterology. 2018 Mar;154(4):1096-1101. doi: 10.1053/j.gastro.2018.01.032. Epub 2018 Feb 3. 5. Schepers NJ, Hallensleben NDL, Besselink MG, Anten MGF, Bollen TL, da Costa DW, van Delft F, van Dijk SM, van Dullemen HM, Dijkgraaf MGW, van Eijck CHJ, Erkelens GW, Erler NS, Fockens P, van Geenen EJM, van Grinsven J, Hollemans RA, van Hooft JE, van der Hulst RWM, Jansen JM, Kubben FJGM, Kuiken SD, Laheij RJF, Quispel R, de Ridder RJJ, Rijk MCM, Römkens TEH, Ruigrok CHM, Schoon EJ, Schwartz MP, Smeets XJNM, Spanier BWM, Tan ACITL, Thijs WJ, Timmer R, Venneman NG, Verdonk RC, Vleggaar FP, van de Vrie W, Witteman BJ, van Santvoort HC, Bakker OJ, Bruno MJ; Dutch Pancreatitis Study Group. Urgent endoscopic retrograde cholangiopancreatography with sphincterotomy versus conservative treatment in predicted severe acute gallstone pancreatitis (APEC): a multicentre randomised controlled trial. Lancet. 2020 Jul 18;396(10245):167-176. doi: 10.1016/S0140-6736(20)30539-0. 6. Andriulli A, Loperfido S, Napolitano G, Niro G, Valvano MR, Spirito F, Pilotto A, Forlano R. Incidence rates of post-ERCP complications: a systematic survey of prospective studies. Am J Gastroenterol. 2007 Aug;102(8):1781-8. doi: 10.1111/j.1572-0241.2007.01279.x. Epub 2007 May 17. PMID: 17509029. 7. Freeman ML, Nelson DB, Sherman S, Haber GB, Herman ME, Dorsher PJ, Moore JP, Fennerty MB, Ryan ME, Shaw MJ, Lande JD, Pheley AM. Complications of endoscopic biliary sphincterotomy. N Engl J Med. 1996 Sep 26;335(13):909-18. doi: 10.1056/NEJM199609263351301. 8. Aawsaj Y, Light D, Horgan L. Laparoscopic common bile duct exploration: 15-year experience in a district general hospital. Surg Endosc. 2016 Jun;30(6):2563-6. doi: 10.1007/s00464-015-4523-0. Epub 2015 Aug 26. PMID: 26307600. 9. Dasari BV, Tan CJ, Gurusamy KS, Martin DJ, Kirk G, McKie L, Diamond T, Taylor MA. Surgical versus endoscopic treatment of bile duct stones. Cochrane Database Syst Rev. 2013 Dec 12;2013(12):CD003327. doi: 10.1002/14651858.CD003327.pub4. PMID: 24338858; PMCID: PMC6464772. 10. Ding G, Cai W, Qin M. Single-stage vs. two-stage management for concomitant gallstones and common bile duct stones: a prospective randomized trial with long-term follow-up. J Gastrointest Surg. 2014 May;18(5):947-51. doi: 10.1007/s11605-014-2467-7. Epub 2014 Feb 4. PMID: 24493296. 11. Bansal VK, Misra MC, Rajan K, Kilambi R, Kumar S, Krishna A, Kumar A, Pandav CS, Subramaniam R, Arora MK, Garg PK. Single-stage laparoscopic common bile duct exploration and cholecystectomy versus two-stage endoscopic stone extraction followed by laparoscopic cholecystectomy for patients with concomitant gallbladder stones and common bile duct stones: a randomized controlled trial. Surg Endosc. 2014 Mar;28(3):875-85. doi: 10.1007/s00464-013-3237-4. Epub 2013 Oct 26. PMID: 24162138. " 
Isogai M. Proposal of the term “gallstone cholangiopancreatitis” to specify gallstone pancreatitis that needs urgent endoscopic retrograde cholangiopancreatography. World J Gastrointest Endosc 2021; 13(10): 451-459 [PMID: 34733406 DOI: 10.4253/wjge.v13.i10.451]
30
"It is the first time to use a nomogram model to predict the prognosis of Primary small cell carcinoma of the esophagus. But this just a single centre in this research, it is more meaningful for multiple hospital to add into this research." 
Zhang DY, Huang GR, Ku JW, Zhao XK, Song X, Xu RH, Han WL, Zhou FY, Wang R, Wei MX, Wang LD. Development and validation of a prognostic nomogram model for Chinese patients with primary small cell carcinoma of the esophagus. World J Clin Cases 2021; 9(30): 9011-9022 [PMID: 34786384 DOI: 10.12998/wjcc.v9.i30.9011]
31
"Biopsy remains gold standard per guidelines for diagnosis in adults with CD. This was an interesting read. But with the sensitivity and specificity of antibody testing, biopsy remains the gold std." 
Losurdo G, Di Leo M, Santamato E, Arena M, Rendina M, Luigiano C, Ierardi E, Di Leo A. Serologic diagnosis of celiac disease: May it be suitable for adults? World J Gastroenterol 2021; 27(42): 7233-7239 [DOI: 10.3748/wjg.v27.i42.7233]
32
"Interesting read. Good summary of available data. " 
Phanchana M, Harnvoravongchai P, Wongkuna S, Phetruen T, Phothichaisri W, Panturat S, Pipatthana M, Charoensutthivarakul S, Chankhamhaengdecha S, Janvilisri T. Frontiers in antibiotic alternatives for Clostridioides difficile infection. World J Gastroenterol 2021; 27(42): 7210-7232 [DOI: 10.3748/wjg.v27.i42.7210]
33
"It was nice to be able to update the radiomics relating to HCC management." 
Yao S, Ye Z, Wei Y, Jiang HY, Song B. Radiomics in hepatocellular carcinoma: A state-of-the-art review. World J Gastrointest Oncol 2021; 13(11): 1599-1615 [PMID: 34853638 DOI: 10.4251/wjgo.v13.i11.1599]
34
"Several functions of extracellular vesicles associated with colorectal cancer were introduced. It would be good if the introduction of cancer treatment targeting EV were also discussed." 
Mammes A, Pasquier J, Mammes O, Conti M, Douard R, Loric S. Extracellular vesicles: General features and usefulness in diagnosis and therapeutic management of colorectal cancer. World J Gastrointest Oncol 2021; 13(11): 1561-1598 [PMID: 34853637 DOI: 10.4251/wjgo.v13.i11.1561]
35
"It makes possible to update the latest news on the treatment of metastatic colorectal cancer." 
Cherri S, Libertini M, Zaniboni A. New drugs for the treatment of metastatic colorectal cancer. World J Gastrointest Oncol 2021; 13(11): 1551-1560 [PMID: 34853636 DOI: 10.4251/wjgo.v13.i11.1551]
36
"The management of pain in pancreatic cancer is challenging. EUS-CPN has been proposed to these patients for almost 20 years since the first procedure by Wieserma and several studies emerged. The authors choose to review this cloudy topic. The manuscript encompassed the main issues and mentioned some innovations in this field. Nevertheless they named all innovations as EUS-CPN or variants of EUS-CPN and I recommend not to do this, as the techniques are different from EUS-CPN, both in the material used and in the target structure. To the end, the original technique has improved, but we still don't have promising and encourage results in the studies. EUS-CPN demonstrated limited efficacy and discouraging long term outcomes. Therefore we can question the real benefit in still using and discussing EUS-CPN for unresectable pancreatic cancer. Probably a revision focused on the new and alternative techniques would help practitioners in the management of pain in this patients. " 
Pérez-Aguado G, de la Mata DMA, Valenciano CML, Sainz IFU. Endoscopic ultrasonography-guided celiac plexus neurolysis in patients with unresectable pancreatic cancer: An update. World J Gastrointest Endosc 2021; 13(10): 460-472 [PMID: 34733407 DOI: 10.4253/wjge.v13.i10.460]
37
"Optimal management of potential organs donor should begin on ICU admission with the aim to reach optimal systemic organ perfusion. Identifying all reversible clinical conditions as goal is crucial for these patients, and this manuscript highlights very clearly this issue, emphasizing specific therapeutic interventions and pointing the utility of serial echocardiographic examinations for the identification of potential reversible cardiac conditions." 
Lazzeri C, Bonizzoli M, Guetti C, Fulceri GE, Peris A. Hemodynamic management in brain dead donors. World J Transplant 2021; 11(10): 410-420 [PMID: 34722170 DOI: 10.5500/wjt.v11.i10.410]
38
"While we welcome these promising researches into artificial intelligence in order to improve the quality of our medical provision, the study by Qiong et al. demonstrates the promising application of artificial intelligence in liver diseases from diagnosis to treatment. This paper systematacially reviews the application and prospects of artificial intelligence in liver diseases, and aims to improve clinicians' awareness of the importance of artificial intelligence in the diagnosis and treatment of liver diseases. AI is an algorithm-based application field that simulates human mental processes and intellectual activities, enabling machines to solve problems with knowledge. In the information age, AI is widely used in the medical field and can provide accurate diagnosis and treatment for complex diseases, reduce medical errors, and promote the development of medicine. However, the over-reliance on such algorithms needs to be further addressed, as well as the claims of Qiong et al that the AI should support rather than replace doctors. In addition, more deep, detailed and clinical investigations are still needed to confirm the potential application of artificial intelligence in the diagnosis and treatment of liver diseases. " 
Li Q, Li JF, Mao XR. Application of artificial intelligence in liver diseases: From diagnosis to treatment. Artif Intell Gastroenterol 2021; 2(5): 133-140 [DOI: 10.35712/aig.v2.i5.133]
39
"Artificial intelligence for cancer detection in upper gastrointestinal endoscopy, current status, and future aspirations In Sarah et al study, they discusses the benefits and pitfalls of machine learning, and artificial intelligence in upper gastrointestinal endoscopy for the detection and characterization of neoplasms. in addition, they also discussed the phases of machine learning and the importance of advanced imaging techniques in upper gastrointestinal endoscopy and its association with artificial intelligence.With the promising development of life sciences and cellular biology in recent years, the underlying pathophysiology and molecular mechanisms of cancer in vivo have been effectively revealed. However, the response efficiency of in vivo cancer drug therapy is still limited. Although the applications of AI integration with upper GI endoscopy could benefit trainees and general practitioners based on these theoretical researches, the establishment of a dataset library accessible to the researchers with upper GI lesions apparent irrespective of the geographical area was difficult. It still needs further detailed investigations to confirm the beneficial effect of artificial intelligence on cancer detection in upper gastrointestinal endoscopy." 
El-Nakeep S, El-Nakeep M. Artificial intelligence for cancer detection in upper gastrointestinal endoscopy, current status, and future aspirations. Artif Intell Gastroenterol 2021; 2(5): 124-132 [DOI: 10.35712/aig.v2.i5.124]
40
"We read with interest an original article by Luo SK et al. In their multicenter study, they investigated the outcome of adult diabetic patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). They conclude that diabetic patients with comorbidities such as hypertension, chronic kidney disease and cerebrovascular disease had worse outcome than patients with diabetes only. The association between obesity and diabetes, particularly Type 2, has been known for several years. This association has not been noted in this paper perhaps because of the retrospective and multiple-center design of their study as they mentioned in the discussion. Indeed, autoimmunity in diabetic patients with COVID-19 has not been studied as an outcome of the SARS-CoV2 infection. Now after almost two years of the emergence of this new coronavirus, several complications during and after the SARS-CoV-2 infection have been reported among which, the autoimmune complications take an important place. " 
Luo SK, Hu WH, Lu ZJ, Li C, Fan YM, Chen QJ, Chen ZS, Ye JF, Chen SY, Tong JL, Wang LL, Mei J, Lu HY. Diabetes patients with comorbidities had unfavorable outcomes following COVID-19: A retrospective study. World J Diabetes 2021; 12(10): 1789-1808 [PMID: 34754379 DOI: 10.4239/wjd.v12.i10.1789]
41
"I read with great interest this research article. It is well-structured and well-written. The authors clearly described the methodology and objectively reported the results. I also liked the way the authors discussed the limitations of the current work and suggested future perspectives. However, it would have been better to know whether the EGDs were interventional or diagnostic. I think including a third control group of matched drug-free patients would have added more value to the comparison. This is mainly because the reported significant hemodynamic differences could occur in any patient population. I also found table 4 a little bit hard to be understood, maybe separating the in-group comparisons (i.e. before/after or single-arm comparisons) from the between-groups comparisons would have made understanding the concept easier. I relied on the written text to understand the table, which I consider a minor negative point. Congratulations on a great paper! " 
Liyen Cartelle A, Nguyen A, Desai PM, Kotwal V, Makhija J, Yu J, Yap JEL. Safety of upper endoscopy in patients with active cocaine use. World J Gastrointest Endosc 2021; 13(10): 510-517 [PMID: 34733411 DOI: 10.4253/wjge.v13.i10.510]
42
"OVERALL A GOOD ARTICLE. MORE IMAGES SHOULD BE THERE. LABELLING SHOULD BE WITH ARROWS AS WELL AS TEXT." 
Pérez-Aguado G, de la Mata DMA, Valenciano CML, Sainz IFU. Endoscopic ultrasonography-guided celiac plexus neurolysis in patients with unresectable pancreatic cancer: An update. World J Gastrointest Endosc 2021; 13(10): 460-472 [PMID: 34733407 DOI: 10.4253/wjge.v13.i10.460]
43
"This review about the different adipose derived MSCs products is very well organized and easy to follow, written in a clear language and rationale sequence. Authors discused the adipose tissue derived products and breifly reviewed some scientific facts and some of the studies conducted with their conclusions accuratly. Only one part was not clearly written in this manuscript regarding the storage of ADSCs , where authors stated that ADSCs can be stored at -80C in liquid nitrogen for up to 6 months in page 1364. Liquid nitrogen is known to have 2 phases a -132 C gas phase and a -196 C liquid phase. Cells when cryopreserved they stay in -80 over night in a tempreture regulator to slowly freeze the cells then tranfered to liguid nirogen (gas or liquid phase) for storage for years. keeping them at -80 would affect the cell viability when thawed." 
Sharma S, Muthu S, Jeyaraman M, Ranjan R, Jha SK. Translational products of adipose tissue-derived mesenchymal stem cells: Bench to bedside applications. World J Stem Cells 2021; 13(10): 1360-1381 [PMID: 34786149 DOI: 10.4252/wjsc.v13.i10.1360]
44
"Dearly respected editor Thank you very much for asking me to comment on this article. The manuscript touched an important issue in Medicine. Diabetes mellitus is on the rise worldwide and no country is immune. The authors discussed the epidemiology and the effects of antidiabetic medications, diet, and robotics. An important area is microbiota transplantation and the effects of bariatric surgery on diabetes remission. Importantly, the diet and medications are not inducing diabetes remission. However, microbiota transplantation and bariatric surgery are very successful. I will draft a letter to the editor on that topic to improve the picture if you give me the chance. Best regards Hyder Mirghani, Associate Professor of Internal Medicine and Endocrine, University of Tabuk, Saudi Arabia" 
Xi Y, Xu PF. Diabetes and gut microbiota. World J Diabetes 2021; 12(10): 1693-1703 [PMID: 34754371 DOI: 10.4239/wjd.v12.i10.1693]
45
"It is an interesting study. Detecting early gastric cancer after eradicating Hp is an essential matter. In this point of view, AI could be a helpful tool. However, there are some concerns to overcome to use in a real-world setting(i.e., black box)." 
El-Nakeep S, El-Nakeep M. Artificial intelligence for cancer detection in upper gastrointestinal endoscopy, current status, and future aspirations. Artif Intell Gastroenterol 2021; 2(5): 124-132 [DOI: 10.35712/aig.v2.i5.124]
46
"It is very interesting study. Team medicine for preventing weight regain after bariatric surgery may be crucial." 
Demerdash HM. Weight regain after bariatric surgery: Promoters and potential predictors. World J Meta-Anal 2021; 9(5): 438-454 [DOI: 10.13105/wjma.v9.i5.438]
47
"Paper titled Artificial intelligence reveals roles of gut microbiota in driving human colorectal cancer evolution warrants the future work AI research for improving our understanding of the roles of gut microbiota in CRC evolution. There are machine-learning techniques have been widely used for the prediction of PPIs thus allowing experimental researchers to study cellular PPI networks. Hence there are more research is needed to fulfill the need of the clinical diagnosis design and selection of treatments. I congratulate the author for the good work." 
Wan XH. Artificial intelligence reveals roles of gut microbiota in driving human colorectal cancer evolution. Artif Intell Cancer 2021; 2(5): 69-78 [DOI: 10.35713/aic.v2.i5.69]
48
"Authors concluded that the article had AI models are related to: (1) the high dependency of the model on the data scale; (2) choice of a proper computational environment, and (3) practical problems of time or computational cost should be assumed. Thus, the future challenges in this discipline begin by smoothing such obstacles as much as possible, which will ultimately end up with AI as the tool of reference in healthcare institutions for a much broader analysis in oncology. Machine learning algorithms and software tools are going to play a vital role in the AI based assessments. " 
Morilla I. Repairing the human with artificial intelligence in oncology. Artif Intell Cancer 2021; 2(5): 60-68 [DOI: 10.35713/aic.v2.i5.60]
49
"The article published in the journal titled Artificial neural network for prediction of acute kidney injury after liver transplantation for cirrhosis and hepatocellular carcinoma had higher scope in futuristic healthcare demands. Further machine learning might help selecting diagnostic procedures with high predictive power and thereby contribute to the improvement of clinical guidelines. Recurrent neural network (RNN), developed by the Google subsidiary company DeepMind, that uses clinical data to predict a time course of the probability that a patient will develop acute kidney failure also favoring the utility of similar scope of research. I congratulate the author for the best work. " 
Bredt LC, Peres LAB. Artificial neural network for prediction of acute kidney injury after liver transplantation for cirrhosis and hepatocellular carcinoma. Artif Intell Cancer 2021; 2(5): 51-59 [DOI: 10.35713/aic.v2.i5.51]
50
"Excellent meta-analysis investigating the risk of post-transplant diabetes mellitus development in the context of the use of immunosuppressive drugs. Excellent paper on not very well studied topic." 
Kotha S, Lawendy B, Asim S, Gomes C, Yu J, Orchanian-Cheff A, Tomlinson G, Bhat M. Impact of immunosuppression on incidence of post-transplant diabetes mellitus in solid organ transplant recipients: Systematic review and meta-analysis. World J Transplant 2021; 11(10): 432-442 [PMID: 34722172 DOI: 10.5500/wjt.v11.i10.432]