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Reader Comments
Publication Name
Article Title
Year Published
1
"This is an interseting editorial that hypothesize in patients with DM, H.pylori are most likely to rely on both amino acids and glucose for its vital activety. This hypothses explain the the high positive rate of H.pylori infection and low eradicaiton rate of H.pylori in patients with DM. This hypothses may provide a new way to improve the eradication rate of H.pylori in patients with DM in clinical practice." 
Reshetnyak VI, Maev IV. Maintaining the metabolic homeostasis of Helicobacter pylori through chronic hyperglycemia in diabetes mellitus: A hypothesis. World J Meta-Anal 2022; 10(5): 238-243 [DOI: 10.13105/wjma.v10.i5.238]
2
"The manuscript touched an important area of Medicine in an important age group, investigation eating disorders is of great importance among adolescents with type 1 diabetes mellitus. The authors introduced their projects, presented their findings, discussed them, and reached a conclusion. Eating disorders are common, when co-exist with diabetes they exacerbate each other deleterious consequences. Importantly, adolescent might decrease the dose or omit insulin in an attempt to reduce weight, resulting in poor glycemic control or even ketoacidosis (diabulimia). Raising the awareness of eating disorders among patients with diabetes is vital to avoid acute and chronic diabetes complications. Hyder Mirghani, Professor of Internal Medicine and Endocrine, University of Tabuk, Saudi Arabia" 
Oliveira Cunha MCS, Dutra FCS, Cavaleiro Brito LMM, Costa RF, Gaspar MWG, Sousa DF, Moura de Araújo MF, Queiroz MVO. Disordered eating behaviour and eating disorder among adolescents with type 1 diabetes: An integrative review. World J Meta-Anal 2022; 10(5): 244-254 [DOI: 10.13105/wjma.v10.i5.244]
3
"The authors presented a well-structured review on an evolving diagnostic approach. They have thoroughly reviewed the bibliography, helping even readers not familliar with the subject to understand and gain knowledge " 
Liu JQ, Ren JY, Xu XL, Xiong LY, Peng YX, Pan XF, Dietrich CF, Cui XW. Ultrasound-based artificial intelligence in gastroenterology and hepatology. World J Gastroenterol 2022; 28(38): 5530-5546 [PMID: 36304086 DOI: 10.3748/wjg.v28.i38.5530]
4
"This is a good retrospective study, suggesting that the FAT somatic mutation is a potentially independent prognostic factor in CRC. The result has clinical value." 
Wang LL, Zheng W, Liu XL, Yin F. Somatic mutations in FAT cadherin family members constitute an underrecognized subtype of colorectal adenocarcinoma with unique clinicopathologic features. World J Clin Oncol 2022; 13(10): 779-788 [PMID: 36337316 DOI: 10.5306/wjco.v13.i10.779]
5
"This review presents several aspects of adjuvant therapy for treatment of pancreatic cancer. Very interesting." 
Zhang HQ, Li J, Tan CL, Chen YH, Zheng ZJ, Liu XB. Neoadjuvant therapy in resectable pancreatic cancer: A promising curative method to improve prognosis. World J Gastrointest Oncol 2022; 14(10): 1903-1917 [PMID: 36310705 DOI: 10.4251/wjgo.v14.i10.1903]
6
"The authors presented a well-structured conducted basic science study, based on current challenges of ischemia reperfusion injury in liver grafts." 
Tong JY, Jiang W, Yu XQ, Wang R, Lu GH, Gao DW, Lv ZW, Li D. Effect of low-dose radiation on thyroid function and the gut microbiota. World J Gastroenterol 2022; 28(38): 5557-5572 [PMID: 36304083 DOI: 10.3748/wjg.v28.i38.5557]
7
"I read with great interest this paper. It is a well-written, comprehensive and precisely presented case report of an extremely rare disease (mucinous adenocarcinoma arising from a tailgut cyst) manifested as large pelvic mass. This condition is well documented by interesting imaging, operative and histopathologic figures. I express my satisfaction and congratulations to the authors for their excellent work. " 
Malliou P, Syrnioti A, Koletsa T, Karlafti E, Karakatsanis A, Raptou G, Apostolidis S, Michalopoulos A, Paramythiotis D. Mucinous adenocarcinoma arising from a tailgut cyst: A case report. World J Clin Oncol 2022; 13(10): 853-860 [PMID: 36337315 DOI: 10.5306/wjco.v13.i10.853]
8
"The article discussed the predictive value of a serum tumor biomarkers scoring system for clinical stage II/III rectal cancer with neoadjuvant chemoradiotherapy comprehensively. " 
Zhao JY, Tang QQ, Luo YT, Wang SM, Zhu XR, Wang XY. Predictive value of a serum tumor biomarkers scoring system for clinical stage II/III rectal cancer with neoadjuvant chemoradiotherapy. World J Gastrointest Oncol 2022; 14(10): 2014-2024 [PMID: 36310703 DOI: 10.4251/wjgo.v14.i10.2014]
9
"The review presented potential mechanisms of mesenchymal stem cells on the treatment of inflammatory bowel disease and summarized the developed strategies for enhancing the therapeutic effect of mesenchymal stem cells. This review is well-organized with clear images." 
Shi MY, Liu L, Yang FY. Strategies to improve the effect of mesenchymal stem cell therapy on inflammatory bowel disease. World J Stem Cells 2022; 14(9): 684-699 [PMID: 36188115 DOI: 10.4252/wjsc.v14.i9.684]
10
"It is a well-written comprehensive review of a common problem of the necessity of cholecystectomy for asymptomatic cholelithiasis presenting the current data. I agree with the proposed discussion with the patient. I would like first to congratulate the authors and second to stress something important. In my point of view in the current era of laparoscopic cholecystectomy, a minimally invasive procedure, it must be performed in young and fit asymptomatic patients with long life expectancy, because later by age advance maybe they will not be fit due to the possible co-existing diseases. However, in frail or elderly patients with short life expectancy, it must be avoided weighing any operative risk. " 
Lee BJH, Yap QV, Low JK, Chan YH, Shelat VG. Cholecystectomy for asymptomatic gallstones: Markov decision tree analysis. World J Clin Cases 2022; 10(29): 10399-10412 [PMID: 36312509 DOI: 10.12998/wjcc.v10.i29.10399]
11
"Great summary on the consecuences of COVID pandemic related with cardiovascular field" 
Vidal-Perez R, Brandão M, Pazdernik M, Kresoja KP, Carpenito M, Maeda S, Casado-Arroyo R, Muscoli S, Pöss J, Fontes-Carvalho R, Vazquez-Rodriguez JM. Cardiovascular disease and COVID-19, a deadly combination: A review about direct and indirect impact of a pandemic. World J Clin Cases 2022; 10(27): 9556-9572 [PMID: 36186196 DOI: 10.12998/wjcc.v10.i27.9556]
12
"dear authors thank you for sharing this well conducted survey with us ; it was nice to read however we want to ask why do the survey was exclusive to male and did not include women? the effect of gender on COVID-19 pandemic has been discussed by many research the disease seems to trigger more severe course in male ;there were some report that gender differences did impose certain differences on the vaccine acceptance and side effects kindly see Alghamdi, A.; Ibrahim, A.; Almutairi, R.; Joseph, M.; Alghamdi, G.; Alhamza, A. A cross-sectional survey of side effects after COVID-19 vaccination in Saudi Arabia: Male versus female outcomes. J. Adv. Pharm. Educ. Res. 2021, 11, 51–56. Sincerely " 
Kang B, Chu H, Youn BY, Leem J. Prevention and management of adverse events following COVID-19 vaccination using traditional Korean medicine: An online survey of public health doctors . World J Clin Cases 2022; 10(28): 10053-10065 [PMID: 36246807 DOI: 10.12998/wjcc.v10.i28.10053]
13
"interesting article for reading...a few clinical trial drugs if so .. can also be included..." 
Warner JB, Guenthner SC, Hardesty JE, McClain CJ, Warner DR, Kirpich IA. Liver-specific drug delivery platforms: Applications for the treatment of alcohol-associated liver disease. World J Gastroenterol 2022; 28(36): 5280-5299 [PMID: 36185629 DOI: 10.3748/wjg.v28.i36.5280]
14
"The diverse functions of caldesmon related to cancer growth and metastasis indicated that it could be a potential biomarker targeting CRC." 
Alnuaimi AR, Nair VA, Malhab LJB, Abu-Gharbieh E, Ranade AV, Pintus G, Hamad M, Busch H, Kirfel J, Hamoudi R, Abdel-Rahman WM. Emerging role of caldesmon in cancer: A potential biomarker for colorectal cancer and other cancers. World J Gastrointest Oncol 2022; 14(9): 1637-1653 [PMID: 36187394 DOI: 10.4251/wjgo.v14.i9.1637]
15
"A variety of adjuvant therapies following surgery targeting liver cancer have been well documented." 
Zeng ZM, Mo N, Zeng J, Ma FC, Jiang YF, Huang HS, Liao XW, Zhu GZ, Ma J, Peng T. Advances in postoperative adjuvant therapy for primary liver cancer. World J Gastrointest Oncol 2022; 14(9): 1604-1621 [PMID: 36187393 DOI: 10.4251/wjgo.v14.i9.1604]
16
"These results may raise awareness that alcohol consumption may increase the risk of colorectal cancer." 
Nong FF, Liang YQ, Xing SP, Xiao YF, Chen HH, Wen B. Alcohol promotes epithelial mesenchymal transformation-mediated premetastatic niche formation of colorectal cancer by activating interaction between laminin-γ2 and integrin-β1. World J Gastroenterol 2022; 28(35): 5154-5174 [PMID: 36188720 DOI: 10.3748/wjg.v28.i35.5154]
17
"It is likely to be an important clinical clue in the treatment of metastatic colorectal cancer based on FOLFOX and FOLFIRI." 
Liu W, Chen FL, Wang K, Bao Q, Wang HW, Jin KM, Xing BC. Irinotecan- vs oxaliplatin-based regimens for neoadjuvant chemotherapy in colorectal liver metastasis patients: A retrospective study. World J Gastrointest Surg 2022; 14(9): 904-917 [PMID: 36185567 DOI: 10.4240/wjgs.v14.i9.904]
18
"Comment on “ Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional in vitro models” Chaolin Deng1, Bin Wu1 1 Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. Corresponding author: Bin Wu, MD, Chief Doctor, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan Road, Wangfujing, Dongcheng District, Beijing 100730, China. Email:wubin0279@hotmail.com Author contributions: Author contributions: Wu B designed and revised the manuscript; Deng CL wrote the manuscript; Abstract We recently read with interest the article“ Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional in vitro models”, this original article was using 2D/3D models of CRC demonstrating the efficacy of anti-tumor with Diiminoquinone (DQI). through further research and analysis, we feel obliged to offer some relevant insights. These comments may deepen our understanding in the context of the three-dimensional (3D) drug screening models and pathological subtypes have different responses to chemotherapies. Keywords: Colorectal cancer, Diiminoquinone, 3D-bioprinting, Pathological subtypes, Drug screening Core Tip: Colorectal cancer is one of the most prevalent cancers worldwide, for inoperable colorectal cancer, chemotherapy is the main treatment option. We recently read with interest the article” Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional in vitro models”. We would like to share our opinion on this article and hope that it will be of some help to the authors and readers   TO THE EDITOR We read with pleasure the article by Alissar Monzer et al. Within this article, the authors assessed the potential anti-tumor effects of Diiminoquinone(DIQ)in Colorectal cancer(CRC) two-dimensional (2D) or three-dimensional (3D) models. Furthermore, the in vivo anti-tumor ability assessment was evaluated using an in vivo model. The authors showed that DIQ could potentially be therapeutic, and inhibit proliferation, invasion, and migration of the tumor cells, by Wnt/-catenin and AKT and ERK pathways. The salient highlight of this article was using multiple 3D models to independent validation of this compound for treatment in CRC. The tumor microenvironment provides essential signals to guide tumor growth and survival[1, 2]. The conventional 2D culture system has long been used in studies of chemotherapy responses. However, the 2D model cannot maintain the interactions of tumor cells, which further complicates the successful translation into the clinic. The authors successfully established the Sphere formation with tumor cell lines, the salient feature of Cancer stem cells (CSCs), and derived-organoid culture with colon tumor tissue. In subsequent studies, DIQ triggered selective tumor inhibition, but not of normal cells, which verified the safety and efficacy. We found some details through further research and analysis and feel obliged to offer some relevant insights. The main role of 3D culture models aimed to mimic the native tumor microenvironment. Tumor microenvironment (TME) and intercellular communication can affect various signal transduction processes in cancer cells. The sphere formation assay is a classic functional approach for studying tumor stem cells. However, this method lack cell-to-cell communication in cancer cells and interstitial cells. 3D-printing is capable of fabricating complex 3D structures with multiple cell types, extracellular matrix components, and growth and signaling factors[3], we consider 3D-bioprinting can use multiple cell types in 3D architecture to better imitate the TME and then in developing more accurate therapeutic drug compared to 2D models[4]. Recently, various 3D-bioprinting drug screening models were reported to achieve higher predictive rates for drug response and novel drug development[2, 5]. Furthermore, 3D-bioprinting could as the foundation for future precision medicine for drug screening. Another interesting finding by Alissar Monzer et al was the DIQ showed the chemotherapy sensitivity in mucinous neoplasms, special pathological subtypes in CRC[6]. The first‐line treatment in patients with metastatic colorectal cancer (mCRC) usually involves chemotherapy. Previous studies demonstrated that patients with mucinous tumors with lesser involves either irinotecan‐ or oxaliplatin‐based chemotherapy benefit with than patients with non-mucinous tumor[7]. In the following, the anti-tumor mechanism of DQI was proved that was activating γH2AX expression to inducer of DNA damage. However, due to the small size of the tissue sample and the low rate of deriving colon patient-derived organoids, the effectiveness of chemotherapy in mucinous tumors needs to be addressed with further research. This may provide directions for targeted therapy with differentiated subtype interventions. In summary, this original article was using 2D/3D models of CRC demonstrating the efficacy of anti-tumor with DQI. However, in light of the complexity of CRC tumor and individual differences in patients, the detailed underlying mechanisms still need much more studies for rational and effective treatment innovation.  1 Habanjar O, Diab-Assaf M, Caldefie-Chezet F, Delort L. 3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages. Int J Mol Sci 2021; 22(22) [PMID: 34830082 PMCID: PMC8618305 DOI: 10.3390/ijms222212200] 2 Ramzy GM, Koessler T, Ducrey E, McKee T, Ris F, Buchs N, Rubbia-Brandt L, Dietrich PY, Nowak-Sliwinska P. Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma. Cancers (Basel) 2020; 12(6) [PMID: 32486365 PMCID: PMC7352800 DOI: 10.3390/cancers12061423] 3 Sbirkov Y, Molander D, Milet C, Bodurov I, Atanasov B, Penkov R, Belev N, Forraz N, McGuckin C, Sarafian V. A Colorectal Cancer 3D Bioprinting Workflow as a Platform for Disease Modeling and Chemotherapeutic Screening. Front Bioeng Biotechnol 2021; 9: 755563 [PMID: 34869264 PMCID: PMC8638705 DOI: 10.3389/fbioe.2021.755563] 4 Neufeld L, Yeini E, Reisman N, Shtilerman Y, Ben-Shushan D, Pozzi S, Madi A, Tiram G, Eldar-Boock A, Ferber S, Grossman R, Ram Z, Satchi-Fainaro R. Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment. Sci Adv 2021; 7(34) [PMID: 34407932 PMCID: PMC8373143 DOI: 10.1126/sciadv.abi9119] 5 Ma K, Zhao T, Yang L, Wang P, Jin J, Teng H, Xia D, Zhu L, Li L, Jiang Q, Wang X. Application of robotic-assisted in situ 3D printing in cartilage regeneration with HAMA hydrogel: An in vivo study. J Adv Res 2020; 23: 123-132 [PMID: 32099674 PMCID: PMC7030996 DOI: 10.1016/j.jare.2020.01.010] 6 Taieb J, Shi Q, Pederson L, Alberts S, Wolmark N, Van Cutsem E, de Gramont A, Kerr R, Grothey A, Lonardi S, Yoshino T, Yothers G, Sinicrope FA, Zaanan A, Andre T. Prognosis of microsatellite instability and/or mismatch repair deficiency stage III colon cancer patients after disease recurrence following adjuvant treatment: results of an ACCENT pooled analysis of seven studies. Ann Oncol 2019; 30(9): 1466-1471 [PMID: 31268130 PMCID: PMC7360150 DOI: 10.1093/annonc/mdz208] 7 Kwon M, Rubio G, Nolan N, Auteri P, Volmar JA, Adem A, Javidian P, Zhou Z, Verzi MP, Pine SR, Libutti SK. FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1. Cancer Res 2021; 81(21): 5523-5539 [PMID: 34417201 PMCID: PMC8563430 DOI: 10.1158/0008-5472.CAN-21-0897] " 
Monzer A, Wakimian K, Ballout F, Al Bitar S, Yehya A, Kanso M, Saheb N, Tawil A, Doughan S, Hussein M, Mukherji D, Faraj W, Gali-Muhtasib H, Abou-Kheir W. Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional in vitro models. World J Gastroenterol 2022; 28(33): 4787-4811 [PMID: 36156922 DOI: 10.3748/wjg.v28.i33.4787]
19
"This article has the following shortcomings: 1. When the blood pressure increases and the heart rate slows down, the blood pressure should be lowered first, but atropine should not be given. As a result, the blood pressure will further increase with the increase of the heart rate. The patient's basic heart rate will be 52 times/min, and after dropping to 41 times/min, after atropine was given, the heart rate maintained at 60-70 times/min, which shows that there are deficiencies in the treatment. 2. The patient did not have adrenal gland examination after operation, and pheochromocytoma could not be excluded." 
Jang MJ, Kim JH, Jeong HJ. Uncontrolled high blood pressure under total intravenous anesthesia with propofol and remifentanil: A case report. World J Clin Cases 2022; 10(26): 9411-9416 [PMID: 36159423 DOI: 10.12998/wjcc.v10.i26.9411]
20
" The article clearly depicts the literature on HCC recurrence after LT " 
Sposito C, Citterio D, Virdis M, Battiston C, Droz Dit Busset M, Flores M, Mazzaferro V. Therapeutic strategies for post-transplant recurrence of hepatocellular carcinoma. World J Gastroenterol 2022; 28(34): 4929-4942 [PMID: 36160651 DOI: 10.3748/wjg.v28.i34.4929]
21
"In the Table 1-5, the authors often use the P<0.0167; P<0.005; P<0.0083......which does not make any sense, P<0.05 already means it have statistical difference, or the authors can also say that P<0.01 if the difference is obvious. This leads to the results section a bit confusing somehow. " 
Jiao HB, Wang W, Guo MN, Su YL, Pang DQ, Wang BL, Shi J, Wu JH. Evaluation of high-risk factors and the diagnostic value of alpha-fetoprotein in the stratification of primary liver cancer. World J Clin Cases 2022; 10(26): 9264-9275 [PMID: 36159417 DOI: 10.12998/wjcc.v10.i26.9264]
22
"TGF-B is known to be an important factor involved in therapeutic resistance, so it is promising as a biomarker." 
Maslankova J, Vecurkovska I, Rabajdova M, Katuchova J, Kicka M, Gayova M, Katuch V. Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancer. World J Gastroenterol 2022; 28(33): 4744-4761 [PMID: 36156927 DOI: 10.3748/wjg.v28.i33.4744]
23
"Dear Editor, I am wondering how the aim and the structure of this article can be the same as the structure of the article that I submitted after the invitation, which was eventually not published after my withdrawal! Kind regards, Vasileios Athanasiou " 
Garcia-Mansilla I, Zicaro JP, Martinez EF, Astoul J, Yacuzzi C, Costa-Paz M. Overview of the anterolateral complex of the knee. World J Clin Cases 2022; 10(24): 8474-8481 [PMID: 36157829 DOI: 10.12998/wjcc.v10.i24.8474]
24
"This study provides an available perspective for prognosis evaluation of ICCs and HCC-CCs undergoing LT, which helps draw attention to the accurate preoperative diagnosis of these patients." 
Brandão ABM, Rodriguez S, Fleck Jr AM, Marroni CA, Wagner MB, Hörbe A, Fernandes MV, Cerski CT, Coral GP. Propensity-matched analysis of patients with intrahepatic cholangiocarcinoma or mixed hepatocellular-cholangiocarcinoma and hepatocellular carcinoma undergoing a liver transplant. World J Clin Oncol 2022; 13(8): 688-701 [PMID: 36160465 DOI: 10.5306/wjco.v13.i8.688]
25
"It has led to a tremendous rise in the quality of reference papers." 
Miao YD, Tang XL, Wang JT, Mi DH. Prognostic role of expression of angiogenesis markers in hepatocellular carcinoma: A bioinformatics analysis. World J Gastroenterol 2022; 28(30): 4221-4226 [PMID: 36157115 DOI: 10.3748/wjg.v28.i30.4221]
26
"interesting article." 
Bartolini I, Nannini G, Risaliti M, Matarazzo F, Moraldi L, Ringressi MN, Taddei A, Amedei A. Impact of microbiota-immunity axis in pancreatic cancer management. World J Gastroenterol 2022; 28(32): 4527-4539 [PMID: 36157926 DOI: 10.3748/wjg.v28.i32.4527]
27
"good" 
Biswas S, Ray Banerjee E. Probiotic treatment of inflammatory bowel disease: Its extent and intensity. World J Immunol 2022; 12(2): 15-24 [DOI: 10.5411/wji.v12.i2.15]
28
"Good" 
Biswas S, Ray Banerjee E. Probiotic treatment of inflammatory bowel disease: Its extent and intensity. World J Immunol 2022; 12(2): 15-24 [DOI: 10.5411/wji.v12.i2.15]
29
"Good" 
Velikova T. Vaccines and autoimmunity during the COVID-19 pandemic. World J Immunol 2022; 12(2): 9-14 [DOI: 10.5411/wji.v12.i2.9]
30
"Interesting topic " 
Santillo E, Migale M. Beta receptor blocker therapy for the elderly in the COVID-19 era. World J Clin Cases 2022; 10(23): 8088-8096 [PMID: 36159512 DOI: 10.12998/wjcc.v10.i23.8088]
31
"Retrospective study Small number of patients No control group included The cause of death is given in only one out of two patients died Findings not different from the prior publication quoted by the authors." 
Azam M, Hudgi A, Uy PP, Makhija J, Yap JEL. Safety of endoscopy in patients undergoing treatments with antiangiogenic agents: A 5-year retrospective review. World J Gastrointest Endosc 2022; 14(7): 416-423 [PMID: 36051996 DOI: 10.4253/wjge.v14.i7.416]
32
"It is well prepared and organised article. However they used an expensive metallic stent instead of a cheaper silicone tube. It can be better to discuss other choises and why they chose stent." 
Cheng SL, Xie L, Wu HW, Zhang XF, Lou LL, Shen HZ. Metal stent combined with ileus drainage tube for the treatment of delayed rectal perforation: A case report. World J Clin Cases 2022; 10(23): 8406-8416 [PMID: 36159539 DOI: 10.12998/wjcc.v10.i23.8406]
33
"Can the method part be presented separately in METHODS? This is more clear and beneficial to readers." 
Rais K, El Eulj O, El Moutaoukil N, Kamaoui I, Bennani A, Kharrasse G, Zazour A, Khannoussi W, Ismaili Z. Solitary pancreatic metastasis from squamous cell lung carcinoma: A case report and review of literature. World J Gastrointest Endosc 2022; 14(7): 455-466 [PMID: 36051994 DOI: 10.4253/wjge.v14.i7.455]
34
"Congratulations to the authors. They highlighted adequately the important role of imaging in diagnosis and the current management strategy of pancreaticobiliary maljunction. It is well known that the long common channel (10-20 mm in length) is a predisposing factor for both gall bladder and common bile duct cancer development in long term due to pancreatic fluid reflux into the extrahepatic biliary tree that causes by converting bile lecithin to lysolecithin, chronic irritation of biliary epithelium and finally carcinogenesis." 
Wang JY, Mu PY, Xu YK, Bai YY, Shen DH. Application of imaging techniques in pancreaticobiliary maljunction. World J Clin Cases 2022; 10(22): 7642-7652 [PMID: 36158479 DOI: 10.12998/wjcc.v10.i22.7642]
35
"It is a well-written comprehensive opinion review on a serious condition of infected necrotizing pancreatitis presenting the current data. I agree absolutely with the proposed step-by-step management. I would like first to congratulate the authors and second to make clear that the on-time detection of sepsis is crucial. Despite the intensive care efforts, the ongoing deterioration of the clinical picture is a strong indication. It is depended on a quick SOFA score (at least two out of three clinical indications are present i.e. tachypnea ≥ 22/ min, low level of consciousness and arterial pressure ≤ 100 mm Hg). This score along with procalcitonin levels >1.8 ng/ml and increased lactates necessitates urgent operation including necrosectomy, peritoneal lavage and wide drainage, either open or laparoscopic. This management gives about a 50% chance of survival in otherwise condemned patients." 
Xiao NJ, Cui TT, Liu F, Li W. Invasive intervention timing for infected necrotizing pancreatitis: Late invasive intervention is not late for collection. World J Clin Cases 2022; 10(23): 8057-8062 [PMID: 36159514 DOI: 10.12998/wjcc.v10.i23.8057]
36
"It is a narrative minireview article. For evidence-based synthesis in favour of beta-blocker in COVID-19, a meta-analysis or systematic review would have given a better insight." 
Santillo E, Migale M. Beta receptor blocker therapy for the elderly in the COVID-19 era. World J Clin Cases 2022; 10(23): 8088-8096 [PMID: 36159512 DOI: 10.12998/wjcc.v10.i23.8088]
37
"It is a nice article. But it lacks an explanation of methodology and statistical analysis aspects, and discussion on preventive and rehabilitative aspects. What search strategy the authors used there is no such mention. Otherwise, it is an informative article." 
Dhaduk K, Khosla J, Hussain M, Mangaroliya V, Chauhan S, Ashish K, Gupta R, Pal S. COVID-19 vaccination and myocarditis: A review of current literature. World J Virol 2022; 11(4): 170-175 [PMID: 36159608 DOI: 10.5501/wjv.v11.i4.170]
38
"Dear editor thank you for sharing this article we have carefully read the article and we would like to congratulate the authors for addressing an important aspect of diagnosing COVID-19 infection .ALL the scientific argument made in the article were sound and concise the advantage of RT-PCR over rapid antigen-detection tests are discussed well .The authors clearly argued the disadvantage of rapid antigen-detection tests in comparison to RT-PCR .However one must not forget the disadvantage of the latter test and its limitation that were intensively examined and addressed in many article ,a good example of these are published in RT- PCR, the gold standard in CoViD-19 diagnosis: the most common pitfalls and their interpretations https://www.oncology-and-cytogenetic-products.com/rt-pcr-the-gold-standard-in-covid-19-diagnosis-the-most-common-pitfalls-and-their-interpretations/ in this article the carful steps that one needs to follow in achieving the best accurate result and to avoid the pitfalls are well discussed, it could be a nice addition to the published article to cover the full aspects of the main research tool which is RT-PCR Best regrades " 
Tabain I, Cucevic D, Skreb N, Mrzljak A, Ferencak I, Hruskar Z, Misic A, Kuzle J, Skoda AM, Jankovic H, Vilibic-Cavlek T. Field evaluation of COVID-19 rapid antigen test: Are rapid antigen tests less reliable among the elderly? . World J Clin Cases 2022; 10(19): 6456-6463 [PMID: 35979325 DOI: 10.12998/wjcc.v10.i19.6456]
39
"An interesting report." 
Tamam MO, Tamam MC. Artificial intelligence technologies in nuclear medicine. World J Radiol 2022; 14(6): 151-154 [PMID: 35978976 DOI: 10.4329/wjr.v14.i6.151]
40
"correct argument" 
Wang JK, Wei W, Zhao DY, Wang HF, Zhang YL, Lei JP, Yao SK. Intestinal mucosal barrier in functional constipation: Dose it change? World J Clin Cases 2022; 10(19): 6385-6398 [PMID: 35979313 DOI: 10.12998/wjcc.v10.i19.6385]
41
"A precise examination regarding eradication therapy of Helicobacter pylori n the East, which allows considerations in multiple directions" 
Cho JH, Jin SY. Current guidelines for Helicobacter pylori treatment in East Asia 2022: Differences among China, Japan, and South Korea. World J Clin Cases 2022; 10(19): 6349-6359 [PMID: 35979311 DOI: 10.12998/wjcc.v10.i19.6349]
42
"The article follows current events and proposes a treatment for COVID-19 using stem cells." 
Cuevas-González MV, Cuevas-González JC. Stem cells as an option for the treatment of COVID-19. World J Clin Cases 2022; 10(18): 6338-6340 [PMID: 35949843 DOI: 10.12998/wjcc.v10.i18.6338]
43
"This paper is a novel attempt to summarize the treatment of diabetes at the level of genomics." 
Huang YY, Zhang XY, Zhu P, Ji L. Development of clustered regularly interspaced short palindromic repeats/CRISPR-associated technology for potential clinical applications. World J Clin Cases 2022; 10(18): 5934-5945 [PMID: 35949837 DOI: 10.12998/wjcc.v10.i18.5934]
44
"It is a nice review in a nutshell on hepatitis E-associated liver failure." 
Cho JH, Jin SY. Current guidelines for Helicobacter pylori treatment in East Asia 2022: Differences among China, Japan, and South Korea. World J Clin Cases 2022; 10(19): 6349-6359 [PMID: 35979311 DOI: 10.12998/wjcc.v10.i19.6349]
45
"In this paper the authors used HAR as yet another measure to assess the prognosis of Gastric cancer. The authors clearly showed the usefulness of HAR in this regard. However, it would have been better if the authors included Hb and Albumin as independent parameters to predict prognosis along with the HAR data they have analyzed. Additionally, it would have been nice to mention whether other factors like UGI bleeding resulted in a low HB. Finally, what was the rationale for coming up with the HAR for this study." 
Hu CG, Hu BE, Zhu JF, Zhu ZM, Huang C. Prognostic significance of the preoperative hemoglobin to albumin ratio for the short-term survival of gastric cancer patients . World J Gastrointest Surg 2022; 14(6): 580-593 [PMID: 35979426 DOI: 10.4240/wjgs.v14.i6.580]
46
"In order to describe the immunophenotype of immune checkpoint (IC) expression in OAC patients before and after radiotherapy, evaluate the effect of checkpoint blocking on cell viability, and pay more and more attention to the spread of anti-tumor immune response, this article studies the effect of radiation and checkpoint blocking on cell viability in OAC patients. A mixed combination of in vitro and in vitro models was used. The serum immune proteins were quantified by enzyme-linked immunosorbent assay. Flow cytometry staining was used to evaluate IC expression in OAC cell lines and OAC biopsies in vitro. The cell viability was evaluated by cell counting kit-8 analysis under the radiation conditions with or without IC blocking. The experimental process and data results are clear. The results of this study have great implications for clinical practice. In the new adjuvant treatment environment, ICIS and ionizing radiation have synergistic effects, which also have obvious implications for the treatment of specific patients in the future. It is a rare good article" 
Donlon NE, Davern M, O’Connell F, Sheppard A, Heeran A, Bhardwaj A, Butler C, Narayanasamy R, Donohoe C, Phelan JJ, Lynam-Lennon N, Dunne MR, Maher S, O’Sullivan J, Reynolds JV, Lysaght J. Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma. World J Gastroenterol 2022; 28(21): 2302-2319 [PMID: 35800186 DOI: 10.3748/wjg.v28.i21.2302]
47
"This review explores recent advances in biomarkers that may help identify clinically relevant PSC subgroups, assist in daily clinical work (e.g., diagnosis, disease stratification or monitoring) and explore potential therapeutic targets. Alkaline phosphatase produced by bile duct epithelial cells is associated with prognosis. In addition, this paper briefly reviews the evidence of these possible serological markers, which may help to solve the unmet clinical needs in PSC, from routine laboratory tests and comprehensive scores, immunoglobulins, other serological biomarkers, and the detection of serological biomarkers of cholangiocarcinoma in PSC. However, as mentioned in the article, the diagnosis of PSC is very difficult. So far, no specific biomarkers of the disease have been identified, and the problems of accurate risk assessment, disease stratification and follow-up strategy of PSC patients have not been solved. Some biomarkers can predict the prognosis of PSC, most of which have not been verified by subsequent studies. But the future clinical practice and research can open up a new way for medical treatment. This article is a very good and enlightening article worthy of continuous attention and reading" 
Tornai D, Ven PL, Lakatos PL, Papp M. Serological biomarkers for management of primary sclerosing cholangitis. World J Gastroenterol 2022; 28(21): 2291-2301 [PMID: 35800183 DOI: 10.3748/wjg.v28.i21.2291]
48
"This paper describes a systematic method of therapeutic drug monitoring (TDM) to manage these patients under the primary or secondary non response of biological agents and immunomodulators (IMM), summarizes the latest data of TDM, focuses on reactive TDM and active TDM, and discusses the effect of TDM on biological agents and thiopurines in the treatment of active IBD. It is analyzed from multiple drug perspectives, such as using research data and conclusions to evaluate the evolution over time and its correlation with clinical outcomes. It is revealed that TDM is helpful to predict the loss of response and prevent treatment failure. Higher serum drug concentration can improve the prognosis and reduce hospitalization, surgery and treatment failure. TDM plays an important role in the treatment outcome of IBD patients using biological agents. And TDM play an important role in the future clinical treatment. However, the use of TDM in IBD patients still has limitations. It is still necessary to further study the importance of different levels of ADA and analyze the correlation. Finally, it will be applied in the medical clinical environment." 
Lodhia N, Rao S. Updates in therapeutic drug monitoring in inflammatory bowel disease. World J Gastroenterol 2022; 28(21): 2282-2290 [PMID: 35800180 DOI: 10.3748/wjg.v28.i21.2282]
49
"This review recommends appropriate monitoring through clinical biochemical score and regular ultrasound evaluation, and summarizes the virus and microenvironment of disease occurrence, as well as the pathophysiology and molecular pathways of chronic infection and carcinogenesis of HBV, HCV and HDV, so as to clarify the mechanism of tumorigenesis, cooperate with the design of future treatment schemes for this kind of cancer, and focus on the impact of clinical monitoring and antiviral treatment on the risk of HCC. The detailed description is carried out from multiple angles of each virus. The diagram is clear and easy to understand, the data is real and detailed, and the research and design data are cited many times. Conclusion HBV and HCV infected patients have a higher risk of carcinogenesis, mainly because of the interaction between viral proteome, transcriptome and host cell molecular pathways, involving inflammation and cell replication. And looking forward to the future, the new biomarkers and risk stratification system may help clinicians identify patients for closer follow-up, so as to achieve more personalized liver cancer monitoring methods." 
Stella L, Santopaolo F, Gasbarrini A, Pompili M, Ponziani FR. Viral hepatitis and hepatocellular carcinoma: From molecular pathways to the role of clinical surveillance and antiviral treatment. World J Gastroenterol 2022; 28(21): 2251-2281 [PMID: 35800182 DOI: 10.3748/wjg.v28.i21.2251]
50
"So the ureteral obstrucion was a necrotic papillae? It seems a very rare entity to me, particularly, never seen it before. The ureteroscopy doesn't showed any other findings? Like distal ureteral stenosis maybe? Otherwise it is a very nice case, congratulations! " 
Pan HH, Luo YJ, Zhu QG, Ye LF. Renal papillary necrosis with urinary tract obstruction: A case report. World J Clin Cases 2022; 10(16): 5400-5405 [PMID: 35812662 DOI: 10.12998/wjcc.v10.i16.5400]