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1
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"Portal hypertension (PHT) is when increased pressure in the portal vein system causes various clinical syndromes, mainly seen in advanced cirrhosis. The Transjugular Intrahepatic Portosystemic Shunt (TIPS) is commonly used to treat PHT and its complications. However, there's still a risk of further health decline and death after TIPS, highlighting the need for accurate models to predict patient outcomes and improve survival rates. Current models for predicting survival after TIPS are not comprehensive, missing some critical factors and their interactions. It is essential to analyze these factors thoroughly to refine prognosis predictions, aiming to better treatment approaches and patient outcomes.
The authors utilized a Bayesian networks（BNs） model combined with clinical data to construct a predictive model for patient survival after TIPS. The meticulous selection of variables through Cox and least absolute shrinkage and selection operator regression methods strengthens the model's reliability. The inclusion of key factors such as age, ascites, hypertension, and postoperative portal vein pressure, among others, ensures a comprehensive assessment of patient prognosis. The model's impressive accuracy, precision, recall, and F1 score, coupled with its ability to predict 2-year survival, make it a valuable tool for clinicians in strategizing treatment and evaluating prognosis. By creating a BN-based model to predict survival, this study marks a big step forward in personalized medicine. It helps the clinical physicians better understand how different factors affecting PHT interact and influence patient outcomes.
However, there are certain limitations to this study. Firstly, the training and verification data used in the model were obtained from the same hospital, which lacks external validation and may introduce selection bias. Additionally, the sample size is limited, necessitating further confirmation of its predictive universality through prospective studies in the future. Secondly，recent research has indicated a close association between sarcopenia and postoperative outcomes in tips procedures. Therefore, it is necessary to investigate whether sarcopenia can be incorporated into this prognostic model in future studies. Furthermore，all existing postoperative prediction models for tips fail to consider how heterogeneity within tips surgeries impacts prognosis. It would be worthwhile exploring whether variables related to tips surgery can be integrated into this prognostic model as well."
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Chen R, Luo L, Zhang YZ, Liu Z, Liu AL, Zhang YW. Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension. World J Gastroenterol 2024; 30(13): 1859-1870 [DOI: 10.3748/wjg.v30.i13.1859]
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2
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"Real-world studies evaluating the effectiveness and adverse effects of tofacitinib have been conducted, affirming its clinical efficacy in moderate to severe ulcerative colitis, mainly in western countries. With this in mind, we have read with great interest the manuscript submitted by Kojima et al. In their retrospective unicentric study involving 111 Asian patients diagnosed with moderate to severe ulcerative colitis, the authors demonstrated tofacitinib was efficient in both inducing and maintaining clinical remission, with a safety profile consistent with other real-world studies. The manuscript is well-written. However, a few suggestions could improve the manuscript. While it was not the primary or secondary outcome of this study, it would have been valuable to include data about other recognizable treatment targets, particularly fecal calprotectin and endoscopic healing. Moreover, inclusion of data regarding the frequency of serious adverse events resulting in hospitalization would be of interest. "
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Kojima K, Watanabe K, Kawai M, Yagi S, Kaku K, Ikenouchi M, Sato T, Kamikozuru K, Yokoyama Y, Takagawa T, Shimizu M, Shinzaki S. Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis. World J Gastroenterol 2024; 30(13): 1871-1886 [DOI: 10.3748/wjg.v30.i13.1871]
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3
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"The study exhibits a robust scientific methodology, utilizing retrospective analysis of clinical data from a substantial sample size of 393 patients. The selection of variables through Cox regression and least absolute shrinkage and selection operator regression methods enhances the credibility of the findings. The establishment of a Bayesian network-based survival prediction model reflects an innovative approach to address the limitations of existing prognostic models. Moreover, the model's validation through cross-validation techniques adds to its reliability. However, further validation studies in diverse patient populations would strengthen the generalizability of the model."
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Chen R, Luo L, Zhang YZ, Liu Z, Liu AL, Zhang YW. Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension. World J Gastroenterol 2024; 30(13): 1859-1870 [DOI: 10.3748/wjg.v30.i13.1859]
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4
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"I believe the authors have made an important review regarding the historical and the current knowledge about chronic gastritis. This minireview focuses on key milestones which were adequately mentioned. English language is adequate and the references represent the most important papers in this regard. I am pleased to have the opportunity of reading this manuscript.
The overall scientific/language quality are adequate considering the high standards of World Journal of Gastroenterology."
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Bordin D, Livzan M. History of chronic gastritis: How our perceptions have changed. World J Gastroenterol 2024; 30(13): 1851-1858 [DOI: 10.3748/wjg.v30.i13.1851]
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5
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"The introduction of the concept of DC is extremely relevant and justified. Many doctors have long tried to achieve comprehensive remission of the disease and the development of clear criteria - which is considered to be DC - will greatly help doctors around the world to prescribe drugs more clearly and track the results. DC also significantly reduces the risk of developing complications of the disease. It is important that the manuscript presents the results of a Systematic Review and Expert Consensus about Disease Clearance as a New Outcome in Ulcerative Colitis. Any infornation of the results of such consensuses in medical journals is useful for expanding the knowledge of doctors"
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Hassan SA, Kapur N, Sheikh F, Fahad A, Jamal S. Disease clearance in ulcerative colitis: A new therapeutic target for the future. World J Gastroenterol 2024; 30(13): 1801-1809 [DOI: 10.3748/wjg.v30.i13.1801]
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6
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"The study conducted by Senchukova, Kalinin, and Volchenko offers a valuable contribution to the field of oncology, particularly in understanding the recurrence of lung squamous cell carcinoma (LSCC) following radical resection and adjuvant chemotherapy. By focusing on stage IIb-IIIa LSCC patients, the research provides insights that are not only relevant but critical for improving patient outcomes in a subset of lung cancer characterized by its challenging prognosis.
The identification of predictors such as a low degree of tumor differentiation, regional lymph node metastases, the presence of loose, fine-fiber connective tissue in the tumor stroma, and fragmentation of the tumor solid component, furnishes clinicians with a more nuanced understanding of recurrence risks. These findings underscore the importance of considering tumor biology and the microenvironment in the post-surgical management of LSCC patients.
Moreover, the use of univariate and multivariate analyses to identify these predictors, along with the application of receiver operating characteristic curves, highlights the study's methodological rigor. The survival analysis further adds to its significance, offering a stark depiction of how these predictors influence disease-free and overall survival rates.
However, it's worth noting that while the study's methodology and its focus on a homogenous patient cohort enhance its validity, the single-center nature and relatively small sample size may limit the generalizability of the findings. Future multicenter studies with larger cohorts are essential to validate these predictors and potentially uncover additional factors influencing LSCC recurrence. Additionally, integrating these predictors into a broader prognostic model, possibly incorporating genetic and molecular markers, could offer a more comprehensive tool for tailoring patient management strategies post-resection.
In conclusion, this study not only advances our understanding of LSCC recurrence but also prompts further research into personalized treatment adjustments based on specific risk factors. Its implications for improving patient surveillance and identifying candidates for more aggressive adjuvant therapies are particularly noteworthy, marking a step forward in the quest to enhance survival outcomes for LSCC patients.
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Senchukova MA, Kalinin EA, Volchenko NN. Predictors of disease recurrence after radical resection and adjuvant chemotherapy in patients with stage IIb-IIIa squamous cell lung cancer: A retrospective analysis. World J Exp Med 2024; 14(1): 89319 [PMID: 38590307 DOI: 10.5493/wjem.v14.i1.89319]
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7
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"I recently read a manuscript titled "Therapeutic role of yoga in hypertension" by Joshi AM, Raveendran AV, and Arumugam M, published in the World Journal of Methodology in 2024, volume 14, issue 1.
I would like to congratulate the authors for providing detailed information about the benefits of yoga in managing hypertension. Practicing yoga is one of the lifestyle modifications in addition to pharmacotherapy for managing high blood pressure.
The term "Yoga" means union, and signifies the merging of Atman, which is the individual consciousness, with Paramatman, the universal consciousness. Yoga originated and practiced since ancient times in India, and it is increasingly being practiced worldwide. Hypertension, which is a medical condition characterized by high blood pressure, is one of the major causes of premature deaths worldwide. It accounts for approximately 14% of total deaths. In this manuscript, the authors describe the beneficial role of yoga practice for people suffering from hypertension. They explain in detail the various components, steps, and stages of yoga, which can help to reduce blood pressure.
Yoga is composed of various components, stages, and steps. These include internal cleansing practices (Shatkriya), warm-up practices (Sharir Sanchalana), Sun salutation (Surya Namaskara), yoga postures (Asana), regulated breathing practices (Pranayama), subtle gestures/body positions (Mudra), meditation/concentration (Dhyana), and effortless relaxation/yogic sleep or body and mind relaxation techniques. These practices are described in detail and designed to promote overall physical and mental well-being including lowering the blood pressure.
Reading through the full article, a few things are clear and everyone must realize and understand that;
1. Yoga practice is not a substitute for pharmacotherapy for hypertension,
2. Yoga is not for any emergency medical conditions,
3. It must be practiced under the supervision of a trained yoga professional,
4. There are no standard yoga components/yoga techniques, and it is not possible to formulate for all,
5. Self-motivation is a must, and sustaining the yoga practice is the real concern,
6. Yoga practice is relatively safe, but may have minor adverse effects like pain, muscle injuries, fatigue,
Overall, to obtain maximum benefit from practicing yoga, it all depends upon the individual’s mental and physical well-being, blood pressure status (mild, moderate, or severe), presence or absence of associated medical/surgical illness, duration of the yoga performed, etc. The literature also supports that yoga helps in reducing blood pressure. Yoga is also helpful in improving the overall well-being of an individual, reducing anxiety and stress, and helping with sleep disorders and a few other medical conditions.
Tanking you all,
With sincere regards,
"
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Joshi AM, Raveendran AV, Arumugam M. Therapeutic role of yoga in hypertension. World J Methodol 2024; 14(1): 90127 [PMID: 38577206 DOI: 10.5662/wjm.v14.i1.90127]
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8
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"Good and interesting editorial article. From my point of view conclusioni is too long and cumbersome, making it not easy to read and understand. Though it does not diminish the value of this article. "
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Xu SX, Yang F, Ge N, Guo JT, Sun SY. Role of albumin-bilirubin score in non-malignant liver disease. World J Gastroenterol 2024; 30(9): 999-1004 [PMID: 38577181 DOI: 10.3748/wjg.v30.i9.999]
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9
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"Good article, interesting to read. "
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Jiang YL, Li J, Zhang PF, Fan FX, Zou J, Yang P, Wang PF, Wang SY, Zhang J. Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models. World J Gastroenterol 2024; 30(9): 1164-1176 [PMID: 38577177 DOI: 10.3748/wjg.v30.i9.1164]
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10
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"The paper is good, But a paragraph on diagnosis of various complications like perianal complications,intestinal strictures can be diagnosed many times by science and symptoms.
Since in many part of the world, including India, we don’t have access to such advanced investigations. Even an ultrasound seems to be a boon for rural part of the world. It’s always better to add a small paragraph about how a good history and clinical examination surpasses. All of these investigations, especially where they are not available."
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Hudson AS, Wahbeh GT, Zheng HB. Imaging and endoscopic tools in pediatric inflammatory bowel disease: What’s new? World J Clin Pediatr 2024; 13(1): 89091 [PMID: 38596437 DOI: 10.5409/wjcp.v13.i1.89091]
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11
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"I value the thoughtful insights presented by Zhang et al. However, the latest iterations of ChatGPT (i.e., GPT-4) are still only able to provide basic personalized suggestions. Moreover, these suggestions are not always evidence-based. Overall, artificial intelligence has a long way to go before it can offer highly targeted and meaningful advice. For now, its recommendations should be taken as a preliminary reference rather than genuine guidance."
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Zhang YF, Liu XQ. Using ChatGPT to promote college students’ participation in physical activities and its effect on mental health. World J Psychiatry 2024; 14(2): 330-333 [PMID: 38464770 DOI: 10.5498/wjp.v14.i2.330]
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12
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"The study, based on a nationwide population, explored comprehensive epidemiological data on IBD in South Korea from 2010 to 2018. This is probably the first study to analyze the epidemiology of IBD in an Asian population. The large sample size of this study provides reliable epidemiological data for IBD studies in Asia."
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Kim S, Lee HJ, Lee SW, Park S, Koh SJ, Im JP, Kim BG, Han KD, Kim JS. Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea, 2010-2018. World J Gastroenterol 2024; 30(9): 1154-1163 [PMID: 38577186 DOI: 10.3748/wjg.v30.i9.1154]
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13
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"Remimazolam, a new ultra-short acting benzodiazepine, was recently approved for procedural sedation and general anesthesia. This study analyze the risk of adverse effects of remimazolam and propofol in the older adults under gastroenteroscopy. As a reader, I am puzzled by the study. The incidence of hypotension in elderly patients is closely related to the dose of sedative drugs, so the dose of remimazolam and propofol in each study should be indicated. Only one study included time to discharge, but in the results Fig 4A, there were two study included it. In the results Fig 4C, only one study (liu 2023) shown the successful sedation rate after administration of remimazolam was lower than propofol, the author should given more detail about that. In the discuss, these contradictory results should be discussed further."
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Li FZ, Zhao C, Tang YX, Liu JT. Safety and efficacy comparison of remimazolam and propofol for intravenous anesthesia during gastroenteroscopic surgery of older patients: A meta-analysis. World J Clin Cases 2024; 12(7): 1272-1283 [PMID: 38524507 DOI: 10.12998/wjcc.v12.i7.1272]
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14
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"Article could have been more descriptive and focussed more on predicting factors of IPN"
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Lv C, Zhang ZX, Ke L. Early prediction and prevention of infected pancreatic necrosis. World J Gastroenterol 2024; 30(9): 1005-1010 [PMID: 38577189 DOI: 10.3748/wjg.v30.i9.1005]
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15
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"Dear Authors,
We would like to congratulate with you for the publication of the article “Transcatheter arterial chemoembolization combined with PD-1 inhibitors and Lenvatinib for hepatocellular carcinoma with portal vein tumor thrombus.” on World Journal of Gastroenterology.
We really much appreciated your work as it reinforces the modern concept that multimodal treatment of advance HCC is of utmost importance to achieve good survival outcomes in a setting featured with dismal prognosis. Still, we believe that some comments are in order.
As far as methodology of the study is concerned, it is needless to say that the quality of the evidence that can be drawn from a retrospective study is dismal. Hence, we would recommend not to state that a superiority of the triple regimen TACE, PD-1 inhibitor, Lenvatinib has been proven. In fact, as you mentioned in the section dedicated to the limits of the article, the small dimension of the study population, its heterogeneity, the retrospective nature of the study along with the selection bias jeopardize the possibility to apply your conclusion to a specific population of HCC patients. In particular, we would suggest, for future research, to select a more specific population of advanced HCC. Although you showed a statistical homogeneity between the two study groups, it must be highlighted that the rate of patients with extra-hepatic disease in the two groups tends to statistical significance and it could be supposed that, with a higher numerosity, the difference could have reached it. This would have meant that one of the possible reasons for the inferiority of the dual regiment in terms of oncological outcomes could be attributed to the greater biological aggressiveness or advanced stage of HCC rather than to the true inferiority of the treatment. Moreover, it could be objectionable the reason why TACE was performed in patients with HCC with very advanced neoplastic portal vein thrombosis and distant metastasis. We would suggest to apply more stringent selection criteria such as exclusion of metastatic HCC and PVTT type III and IV. This would help identify a specific population of HCC patient that could benefit from the advantages you advocate a triple regimen seems to provide them with. Another suggestion to improve the applicability of the study would be to limit the use of immune-check point inhibitors to a single specific drug rather than to a wide group of different molecules and to specify the criteria that prompt the use of a specific molecule over another. Finally, it has to be noted that the vast majority of the population was affected by HBV-related liver cirrhosis. We know about the trend in changing prevalence of the etiology of liver cirrhosis in Western countries, with increasing rate of dysmetabolic and alcoholic etiologies over the viral ones, mainly due to the efficacy and wide distribution of the treatment of HCV with DAA. One could postulate that HCC harbored on HBV-related cirrhosis could be differently aggressive compared to other etiologies making it difficult to draw similar conclusion in a Western setting, where other etiologies are more prevalent and related HCC can possibly have different biological profile.
From a mere linguistic point of view, we would suggest the following correction:
- Line 3 of the introduction, change “concerning” with “accounting for”.
- Inclusion criteria n° 9: we would express this concept saying that the presence of extra-hepatic disease would not represent an exclusion criterion.
- In Table 1, the unit for bilirubin is clearly expressed in mmol/l rather than mg/dl.
- There is no agreement between the Figure 2C (p = 0.029) and what expressed in table 3 (p = 0.009).
- In the last line of first paragraph on page 852, we would rephrase as following “such association was not investigated”.
- Line 5 and 6 on the same paragraph, we would rephrase as following: “It means that patients with TACE-induced sever liver injury may have limited efficacy as liver function deterioration can hinder the administration of systemic drugs”.
"
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Wu HX, Ding XY, Xu YW, Yu MH, Li XM, Deng N, Chen JL. Transcatheter arterial chemoembolization combined with PD-1 inhibitors and Lenvatinib for hepatocellular carcinoma with portal vein tumor thrombus. World J Gastroenterol 2024; 30(8): 843-854 [PMID: 38516240 DOI: 10.3748/wjg.v30.i8.843]
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16
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"Good article. It posts questions from everyday practice that are sometimes hard to answer. Probably readers would like to see more details and regimens. But this editorial shows directions in new era settings."
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Zhong JH. Adjuvant therapy for hepatocellular carcinoma: Dilemmas at the start of a new era. World J Gastroenterol 2024; 30(8): 806-810 [PMID: 38516235 DOI: 10.3748/wjg.v30.i8.806]
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17
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"Very interesting editorial article. Authors underlined features of article of Zhang et al. Refrences are prettyt new and relevant. Discussion and conclusions are accurate and include future perspectives."
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Ramírez-Mejía MM, Méndez-Sánchez N. From prediction to prevention: Machine learning revolutionizes hepatocellular carcinoma recurrence monitoring. World J Gastroenterol 2024; 30(7): 631-635 [PMID: 38515945 DOI: 10.3748/wjg.v30.i7.631]
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18
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"Dear Editor,
Greetings for the day. First and foremost, I would like to express my gratitude for granting me the opportunity to submit reader's comments in your esteemed journal.
While reading the article with keen interest, I have noted several points that require clarification:
In the Materials and Methods section, inclusion criteria number 5 states, "thyroid function showing normal range of free T4 (FT4) and thyroid stimulating hormone (TSH) levels (< 10 Uiu/L), which was not treated after the initial diagnosis." However, in Table 2 of the Results section, all three groups exhibit TSH levels greater than >10 mU/L. This contradiction needs clarification, and if there is a discrepancy in units mentioned between the Materials and Methods section and the Results, it should be rectified for consistency.
In Table 4, the levels of LDL-C have increased in all three groups (controls, test A & B). However, the Discussion section fails to address this result adequately.
In the Discussion, the following statement appears: "As we all know, dyslipidemia in T2DM patients is mainly manifested by increased levels of TC, TG, and LDL-C and decreased levels of LDL-C." This statement seems to contain a typographical error as it contradicts itself by referring to both an increase and decrease in LDL-C levels in the same sentence.
In the Conclusion section, the final statement is ambiguous: "The elevated 25 (OH) D3, FT4, and TGAB levels were reduced." However, in the results section of the article with intervention, 25 (oh) D3 levels increased, FT4 increased, and TGAB levels decreased. This contradiction requires clarification and correction.
I trust that addressing these points will enhance the clarity and accuracy of the article, thereby contributing to the integrity of the research findings.
Thank you for considering my feedback.
Sincerely,
Dr Kotha Sugunakar Reddy
AIIMS - Bibinagar, Hyderabad, INDIA"
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Feng F, Zhou B, Zhou CL, Huang P, Wang G, Yao K. Vitamin D, selenium, and antidiabetic drugs in the treatment of type 2 diabetes mellitus with Hashimoto's thyroiditis. World J Diabetes 2024; 15(2): 209-219 [PMID: 38464371 DOI: 10.4239/wjd.v15.i2.209]
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19
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"This review describes potential interactions between genetic polymorphisms and dietary factors regarding T2DM susceptibility and disease progression, it elaborates novel genotype-based dietary strategies for the prevention and clinical management of T2DM, and also hypothesises future directions including the integration of genetics with another histological tool. This article develops new genotype-based dietary strategies to improve T2DM control, and these studies help to explain the heterogeneity of T2DM susceptibility and the development of associated systemic complications, as well as understanding the relevance of human genomic studies to disease stratification and precision nutrition. Certainly, this article provides a systematic account of genetic studies and precision nutrition in T2DM populations, and although the article has described glycaemic indicators in patients with T2DM in different countries and ethnic populations based on genotypes and diets, the article needs more studies to expand and confirm the effects of genes and diets of ethnic minorities in other regions on T2DM, and it can also provide further detailed explanations on the clinical management of the T2DM population can also be further explained in detail."
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Ramos-Lopez O. Genotype-based precision nutrition strategies for the prediction and clinical management of type 2 diabetes mellitus. World J Diabetes 2024; 15(2): 142-153 [PMID: 38464367 DOI: 10.4239/wjd.v15.i2.142]
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20
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"It is well known that H. pylori infection is a common infection worldwide and the treatment of H. pylori remains a global concern due to the prevalence of antimicrobial resistance. This study was a single-center, prospective, open-label, randomized study comparing the efficacy of optimized sequential therapy for 14 days with that of combination therapy for 10 days and 14 days. Data analysis showed that the use of optimized sequential therapy improved the eradication rate of H. pylori infection and reduced the incidence of adverse reactions. This provides us clinicians with more radical treatment options for H. pylori infection. It is expected that this study can be further verified in multi-center and multi-region studies."
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Seddik H, Benass J, Berrag S, Sair A, Berraida R, Boutallaka H. Optimized sequential therapy vs 10- and 14-d concomitant therapy for eradicating Helicobacter pylori: A randomized clinical trial. World J Gastroenterol 2024; 30(6): 556-564 [PMID: 38463026 DOI: 10.3748/wjg.v30.i6.556]
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21
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"In this paper, an early screening model was established to identify the high-risk population of colorectal cancer, and the model was internally validated using bootstrapping resampling technique. The data analysis was detailed and rigorous, and the results were reliable. Compared with traditional screening methods, the advantages of this method are that it is simple, rapid, and can be completed without invasive procedures, and it is better carried out in healthy people. More sample size and multi-center data analysis are expected."
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Xu LL, Lin Y, Han LY, Wang Y, Li JJ, Dai XY. Development and validation of a prediction model for early screening of people at high risk for colorectal cancer. World J Gastroenterol 2024; 30(5): 450-461 [PMID: 38414586 DOI: 10.3748/wjg.v30.i5.450]
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22
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"The study and its results are valuable and can be readily applied in clinical practice, however the use of a different PPI solely on the sequential therapy group makes it difficult to assess if the difference in edificacy/cost is due to concomitant vs sequential or Omeprazole vs Rabeprazole"
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Seddik H, Benass J, Berrag S, Sair A, Berraida R, Boutallaka H. Optimized sequential therapy vs 10- and 14-d concomitant therapy for eradicating Helicobacter pylori: A randomized clinical trial. World J Gastroenterol 2024; 30(6): 556-564 [PMID: 38463026 DOI: 10.3748/wjg.v30.i6.556]
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23
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"I enjoyed reading the manuscript Development and validation of a prediction model for early screening of people at high risk for colorectal cancer by Xu et al. Generally speaking, the background, aims, methods, results, and conclusions were clear and well-executed. There were a few word choices that may not have reflected the sentiment as thoroughly as intended. For example, in the background of the abstract, I don't know if I would describe CRC as a "threat", but maybe a "serious condition with significant mortality"; rather than the current "situation" of early screening, maybe "state" instead; and rather than describing early screening as "not optimistic", instead saying "not ideal". In the results section of the abstract, I would omit the word "information" after "family history". These are very minute remarks, but clearer language would optimize the quality of the abstract.
I applaud the manuscript for the size of the population studied; however, I think the results would be clearer if commas were used for numbers larger than 999.
The introduction provided nice background into the state of CRC screening specific to the population of the study. I enjoyed the inclusion of the study on the diagnostic delays in southern China; however, I'm not sure much was added with the inclusion of the cross-sectional study on CRC knowledge and awareness in the Caribbean as this population is vastly different from that of the study. Again, a small comment on language: I wouldn't describe colonoscopic screening as not "popular", but rather not "routine" or "widely accepted by the general public". The intention of the statement was clear, but I think better language could have been used.
I thought the methods section was thorough and explained each component of the study very well. Another small language comment on "Drinking alcohol". I would say "alcohol use" instead.
The results were interesting and displayed nicely in the tables and figures. In the very last sentence of this section, I don't know what "DCA" is, and I didn't see it defined anywhere else in the paper, although it's possible I missed it.
I thought the discussion was the strongest section of the manuscript. The results were contextualized well with commentary on the existing literature and framed in the setting of existing data on CRC screening. The implications of the findings on actions that could improve clinical diagnosis in order to reduce poor outcomes were well-communicated. "
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Xu LL, Lin Y, Han LY, Wang Y, Li JJ, Dai XY. Development and validation of a prediction model for early screening of people at high risk for colorectal cancer. World J Gastroenterol 2024; 30(5): 450-461 [PMID: 38414586 DOI: 10.3748/wjg.v30.i5.450]
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24
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"I enjoyed reading the manuscript Development and validation of a prediction model for early screening of people at high risk for colorectal cancer by Xu et al. Generally speaking, the background, aims, methods, results, and conclusions were clear and well-executed. There were a few word choices that may not have reflected the sentiment as thoroughly as intended. For example, in the background of the abstract, I don't know if I would describe CRC as a "threat", but maybe a "serious condition with significant mortality"; rather than the current "situation" of early screening, maybe "state" instead; and rather than describing early screening as "not optimistic", instead saying "not ideal". In the results section of the abstract, I would omit the word "information" after "family history". These are very minute remarks, but clearer language would optimize the quality of the abstract.
I applaud the manuscript for the size of the population studied; however, I think the results would be clearer if commas were used for numbers larger than 999.
The introduction provided nice background into the state of CRC screening specific to the population of the study. I enjoyed the inclusion of the study on the diagnostic delays in southern China; however, I'm not sure much was added with the inclusion of the cross-sectional study on CRC knowledge and awareness in the Caribbean as this population is vastly different from that of the study. Again, a small comment on language: I wouldn't describe colonoscopic screening as not "popular", but rather not "routine" or "widely accepted by the general public". The intention of the statement was clear, but I think better language could have been used.
I thought the methods section was thorough and explained each component of the study very well. Another small language comment on "Drinking alcohol". I would say "alcohol use" instead.
The results were interesting and displayed nicely in the tables and figures. In the very last sentence of this section, I don't know what "DCA" is, and I didn't see it defined anywhere else in the paper, although it's possible I missed it.
I thought the discussion was the strongest section of the manuscript. The results were contextualized well with commentary on the existing literature and framed in the setting of existing data on CRC screening. The implications of the findings on actions that could improve clinical diagnosis in order to reduce poor outcomes were well-communicated. "
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Deng Y, Jiang Y, Jiang T, Chen L, Mou HJ, Tuo BG, Shi GQ. Evaluation of the efficacy and safety of endoscopic band ligation in the treatment of bleeding from mild to moderate gastric varices type 1. World J Gastroenterol 2024; 30(5): 440-449 [PMID: 38414583 DOI: 10.3748/wjg.v30.i5.440]
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25
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"good"
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Lemos FFB, Castro CT, Silva Luz M, Rocha GR, Correa Santos GL, de Oliveira Silva LG, Calmon MS, Souza CL, Zarpelon-Schutz AC, Teixeira KN, Queiroz DMM, Freire de Melo F. Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy. World J Gastroenterol 2024; 30(6): 579-598 [PMID: 38463019 DOI: 10.3748/wjg.v30.i6.579]
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26
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"Worth in-depth learning"
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Seddik H, Benass J, Berrag S, Sair A, Berraida R, Boutallaka H. Optimized sequential therapy vs 10- and 14-d concomitant therapy for eradicating Helicobacter pylori: A randomized clinical trial. World J Gastroenterol 2024; 30(6): 556-564 [PMID: 38463026 DOI: 10.3748/wjg.v30.i6.556]
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27
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"good"
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Wang BC, Fan JG. Unmet needs in biomarkers for autoimmune pancreatitis diagnosis. World J Gastroenterol 2024; 30(6): 523-526 [PMID: 38463027 DOI: 10.3748/wjg.v30.i6.523]
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28
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"very good"
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Deng Y, Jiang Y, Jiang T, Chen L, Mou HJ, Tuo BG, Shi GQ. Evaluation of the efficacy and safety of endoscopic band ligation in the treatment of bleeding from mild to moderate gastric varices type 1. World J Gastroenterol 2024; 30(5): 440-449 [PMID: 38414583 DOI: 10.3748/wjg.v30.i5.440]
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29
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"good"
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Ravikulan A, Rostami K. Leveraging machine learning for early recurrence prediction in hepatocellular carcinoma: A step towards precision medicine. World J Gastroenterol 2024; 30(5): 424-428 [PMID: 38414588 DOI: 10.3748/wjg.v30.i5.424]
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30
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"The title did not reflect the discussion in the article.
The topic is extremely relevant right now. Semaglutide has the potential to prolong the honeymoon phase, however, we need more evidence. The study published in NEJM and cited in this article lacks more details so that we can understand what happened during the treatment."
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Nassar M, Chaudhuri A, Ghanim H, Dandona P. Glucagon-like peptide-1 receptor agonists as a possible intervention to delay the onset of type 1 diabetes: A new horizon. World J Diabetes 2024; 15(2): 133-136 [PMID: 38464377 DOI: 10.4239/wjd.v15.i2.133]
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31
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"Very well organized and presented manuscript in a critical subject.
The authors at first/in introduction present very interesting (statistical) facts about cancer in general and about colorectal cancer, as well as the economic benefits of a larger early screening versus late treating.
They present the vast majority of diagnostic tests, invasive and non-invasive, with an explanatory manner even for readers who have not heard all of these tests before, making them easy to understand with supporting data about sensitivity, specificity and advantages and disadvantages of each method.
In “why are these screening modalities not enough” section, the authors explain their thesis with evidence-based data, which also justify in the next paragraphs. They also refer studies about ways to improve patient’s adherence and studies that combined available diagnostic methods in order to achieve greater sensitivity and specificity.
I found very captivating the screening in the period of covid-19 paragraph as well as early colorectal cancer paragraph. Especially the second one, is a hot-topic which tends to show that the early age colorectal cancer is going to raise more our concerns in the near future.
The authors also use data from a variety of national health systems which emphasizes the existence of differences around the world and around the different populations.
According to my opinion, the authors could have added a small section, about the promising future perspectives in early diagnosis of colorectal cancer (for example AI in diagnosis of colorectal cancer). (there is only a brief mention in conclusion)
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Tonini V, Zanni M. Why is early detection of colon cancer still not possible in 2023? World J Gastroenterol 2024; 30(3): 211-224 [PMID: 38314134 DOI: 10.3748/wjg.v30.i3.211]
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"occurrence in hepatitis C virus associated cirrhosis: A real-world study” has been read enthusiastically. I wholeheartedly congratulate the authors on their well-written article. The topic is of interest to the scientific audience of the journal and the article is coherent, with a logical progression of ideas from one section to the next. However, I would like to highlight a few points, which I believe would not only be helpful to the readers but also highlight avenues for future research.
First, the retrospective design of the study makes it subject to bias, thus questioning the credibility of its results. Second, the modest sample size (only 427 patients) is an important limitation of this study which should have been mentioned in the limitations section. Third, excluding patients less than 18 years of age puts the credibility of the study findings into question. Fourth, The study enrolled only the patients admitted in the hospital. The authors should have provided an explanation for excluding patients in ambulatory settings. Last, although the authors mentioned that the data on Body mass index (BMI) were collected, they didn’t report it in the baseline characteristics table. Large multicenter prospective studies are needed to validate the results of this study.
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Tao XM, Zeng MH, Zhao YF, Han JX, Mi YQ, Xu L. Direct-acting antivirals failed to reduce the incidence of hepatocellular carcinoma occurrence in hepatitis C virus associated cirrhosis: A real-world study. World J Hepatol 2024; 16(1): 41-53 [PMID: 38313240 DOI: 10.4254/wjh.v16.i1.41]
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"A promising class of PDT photosensitizers for triple negative breast cancer：the luminescent platinum (II) complex with BODIPY derivative
Jia-Ming Lei†1, Zi-Han Wu†2, Shi-Jiao Cheng1, Fei-Fei Lu1, Mei-Chun Hu1* and Li Lin1*
1 Key Laboratory of Environmental Related Diseases and One Health, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, China
2 Xianning Traditional Chinese Medicine Hospital, Xianning, China
*Correspondence:
Mei-Chun Hu (Email: humeichun.530@163.com)
Li Lin (Email: alison1012li@163.com)
† These authors contributed equally to this work and share first authorship
Breast cancer is the most common lethal malignant tumor in women and the second leading cause of cancer-related mortality worldwide [1], of which triple-negative breast cancer (TNBC) accounts for about 20% of breast cancer, which is prone to recurrence and metastasis, and has a high degree of malignancy and death rate [2]. Due to lack of HR and HER2 expression [3,4], endocrine therapy and anti-HER2 therapy for TNBC are usually proved ineffective [5].
Clinical studies have shown that photodynamic therapy (PDT) can prolong the survival time of cancer patients and improve the quality of life of patients. It has become one of the latest candidates for tumor treatment with broad prospects [6].
In our work recently reported in the paper entitled “Identification of a luminescent platinum (II) complex with BODIPY derivative as novel photodynamic therapy agent for triple negative breast cancer cells” in Journal of Inorganic Biochemistry, we designed a luminescent monofunctional platinum (II) complex with a BODIPY derivative, namely, I2BC-Pt, as a novel high PDT anti-triple-negative breast cancer (TNBC) agent. Under the irradiation of green light (520 nm), I2BC-Pt exhibited superior PDT effect against TNBC and impeded DNA repair by attenuating RAD51, FoxM1 and BRCA1/2 and induced p53-mediated apoptosis in TNBC cells.
I2BC-Pt has good cellular selectivity and can be used as a promising photodynamic therapeutic agent, particularly suitable for triple-negative breast cancer. We examined the PDT anticancer activities of two novel monofunctional Pt (II) complexes BC-Pt, I2BC-Pt, and cisplatin toward six types of cancer lines, such as human TNBC cells (MDA-MB-468 and MDA-MB-231), human neuroblastoma cells (SH-SY5Y), human lung adenocarcinoma cells (HCC78), human pancreatic cancer cells (SW1990), human colorectal cancer cells (HCT116) and two types of normal cells including human immortal liver cells (THLE-3), human embryo kidney cells (SV40). In order to figure out the half of the maximum inhibitory concentrations (IC50) of each coordinator, we exposed the BC-Pt, I2BC-Pt and cisplatin for 48 h and derived the IC50 values. The green light (520 nm, 5 mW) had IC50 values of I2BC-Pt in the range of 0.11~0.71μM, much lower than BC-Pt and cisplatin which demonstrated good photodynamic efficacy. More interestingly, the human TNBC cells (MDA-MB-231) were sensitive to I2BC-Pt among all selected cancer cells, and showed satisfactory cytotoxicity with dark IC50 values of 6.1±0.5 μM and light IC50 values of 0.11±0.02 μM, which is the lowest. This indicates that I2BC-Pt exhibits optimal inhibitory efficacy against TNBC.
Tumor localization of photosensitizers is an important factor in determining the efficacy of PDT. We performed confocal microscopic experiments using MDA-MB-231 cells as a model. The colocalization of Pt (II) complexes (BC-Pt, I2BC-Pt and cisplatin) with DAPI and MitoTracker Red proved that the Pearson's correlation coefficient between the green fluorescence of I2BC-Pt and the red fluorescence of MitoTracker was about 0.89 after 30 min of dark incubation with I2BC-Pt, implying that was I2BC-Pt mainly accumulated in the mitochondrion. and the cellular imaging data demonstrated that I2BC-Pt is a PDT agent that can be specifically localized within the mitochondria of cancer cells, with significant selectivity and safety.
PDT can produce lethal cytotoxic effects, including induction of apoptosis, autophagy and cell necrosis. Since I2BC-Pt is mainly localized in mitochondria, we speculate that apoptosis may be the main mode of cell death. p53 protein dysfunction is closely related to mitochondria dysfunction and cell apoptosis. By protein immunoblotting hybridization experiments, the results showed that I2BC-Pt caused apoptosis and activated the p53-Bax-Bcl-2-caspase9 protein-caspase3-PARP1 pathway.
To examine whether DNA repair is involved in the process of DNA damage, we investigated the level fluctuations of RAD51 and FoxM1 which are both crucial factors associated with DNA repair, in MDA-MB-231 cells treated by cisplatin, BC-Pt and I2BC-Pt . Under light irradiation, RAD51 and FoxM1 have synchronous reduction by I2BC-Pt compared to the control as well as cisplatin-treated groups. The results indicating that I2BC-Pt not only induced DNA damage severely but also hindered the repair of DNA. BRCA1 and BRCA2 are two genes that inhibit the occurrence of breast cancer containing TNBC, and play an important role in DNA damage repair. We further examined the expression of BRCA1 and BRCA2. Compared to control group, we found that the levels of these two genes decreased when MDA-MB-231 cells treated with I2BC-Pt under the light irradiation, demonstrating the genomic heterogeneity of MDA-MB-231 cells was significantly reduced with the expression of BRCA1 and BRCA2 protein expression levels declined. Thus, I2BC - Pt exhibit the highest phototoxic among the three Pt (II) complexes, as mentioned above.
In conclusion, we have developed a series of monofunctional luminescent platinum compounds with BODIPY derivatives, which have a strong photodynamic responsiveness, high targeting as well as low toxic side effects, which are very promising new generation of photosensitizers, especially for triple-negative breast cancer, and it is worthy of further research and investigation.
Funding
This work was supported by the National Natural Science Foundation of China (No. 31900853)，the Science and Technology Research Project of Hubei Education Department (B2019161)
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
[1] R.L. Siegel, K.D. Miller, H.E. Fuchs, A. Jemal, Cancer statistics, 2022, CA Cancer J. Clin. 72 (2022) 7–33.
[2] LI Y, ZHANG H J, MERKHER Y, et al. Recent advances in therapeutic strategies for triple-negative breast cancer[J].J Hematol Oncol, 2022, 15(1): 1-30.
[3] S.C. Houghton, S.E. Hankinson, Cancer progress and priorities: breast cancer, Cancer Epidemiol. Biomark. Prev. 30 (2021) 822–844.
[4] L. Angus, M. Smid, S.M. Wilting, J. van Riet, A. Van Hoeck, L. Nguyen, S. NikZainal, T.G. Steenbruggen, V.C.G. Tjan-Heijnen, M. Labots, J. van Riel, H. J. Bloemendal, N. Steeghs, M.P. Lolkema, E.E. Voest, H.J.G. van de Werken, A. Jager, E. Cuppen, S. Sleijfer, J.W.M. Martens, The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies, Nat. Genet. 51 (2019) 1450–1458.
[5] R.N. Pedersen, B.O. Esen, L. Mellemkjaer, P. Christiansen, B. Ejlertsen, T.L. Lash, M. Norgaard, D. Cronin-Fenton, The incidence of breast cancer recurrence 10-32 years after primary diagnosis, J. Natl. Cancer Inst. 114 (2022) 391–399.
[6] BIKFALVI A, COSTA C A, AVRIL T, et al. Challenges in glioblastoma research: focus on the tumor microenvironment[J]. Trends Cancer,2023,9 (1) :9
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Yakar M, Etiz D. Prognostic factors of breast cancer brain metastasis. World J Clin Oncol 2024; 15(1): 5-8 [PMID: 38292663 DOI: 10.5306/wjco.v15.i1.5]
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"This study comprehensively reviews the available studies and provide a rough idea regarding the timing of correction and when to remove the implants.
The only weakness is that it is a review study rather than a systematic review. So it can help to provide an approximate idea regarding the timing but without more accurate systematically searches, identifies, selects, appraises, and synthesizes research evidence relevant to the question.
Otherwise, I think it is well written article as a review article"
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Zeng JF, Xie YY, Liu C, Song ZQ, Xu Z, Tang ZW, Wen J, Xiao S. Effective time, correction speed and termination time of hemi-epiphysiodesis in children. World J Orthop 2024; 15(1): 1-10 [PMID: 38293262 DOI: 10.5312/wjo.v15.i1.1]
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"This article is truly impressive! The author's analysis and thoughtful insights have been enlightening. Through detailed data analysis and clear reasoning, the author effectively elucidates the significance of the research and the value of its conclusions. I highly appreciate the author's research methods and results, as this article not only offers valuable insights to the academic community but also prompts profound contemplation for readers. I look forward to more research findings from the author in the future!"
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Emile SH, Ragheb J. Toward less invasive coloproctology: The future is out there. World J Gastroenterol 2024; 30(3): 199-203 [PMID: 38314131 DOI: 10.3748/wjg.v30.i3.199]
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"Thank you very much for giving us a chance for a comments of on “Analysis of the potential biological value of pyruvate dehydrogenase E1 subunit β in human cancer”. Though the study is interesting, and help define new ways in targeted therapeutics to combat different cancers by modulation in expression levels of the mitochondrial PDHB gene. We would further endorse to manage or invite a special collection on this topic, so this arena be highlighted for clinical use."
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Rong Y, Liu SH, Tang MZ, Wu ZH, Ma GR, Li XF, Cai H. Analysis of the potential biological value of pyruvate dehydrogenase E1 subunit β in human cancer. World J Gastrointest Oncol 2024; 16(1): 144-181 [PMID: 38292838 DOI: 10.4251/wjgo.v16.i1.144]
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"I read with great interest the manuscript by Chen J et al. analysing the prognostic value of simple biomarkers bilirubin and serum γ-glutamyltranspeptidase levels in type-2 diabetes mellitus patients with acute coronary syndrome. The paper discusses a rather unexplored topic and the authors have provided their suggestions subsequent to their findings.
However there are major concerns which could help improve the quality of research in this field in future by the authors or other researchers worldwide.
1) The overall quality of englight language is suboptimal with inappropriate choice of words at many places.
2) The study design is inherently prone to unaccounted biases and the hence the study has to be validated in larger prospective and randomised studies
3) There is confusion regarding the study population selection. Were they consecutive patients or randomly chosen. This may have significantly altered the results.
4) The description of sample size should have been mentioned considering this was a retrospective study.
5) The authors could have followed all participants for 3 months and then compared the outcomes. Why did they only choose DM + ACS and not ACS alone per say. Does bilirubin and serum γ-glutamyltranspeptidase metabolism differ in DM?
6) The rationale of choosing these should have been further explained in greater detail. Giving 1-2 prior studies and their results is not sufficient.
7) overall I do not see how this study can be applicable in clinical practice. Small numbers, retrospective data with likely confounders unaccounted for limit is value in its current form. Perhaps the authors can take these suggestions and further explore the value of these biomarkers in real world setting."
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Chen J, Zhang WC, Tang XQ, Yin RH, Wang T, Wei XY, Pan CJ. Predictive value of bilirubin and serum γ-glutamyltranspeptidase levels in type-2 diabetes mellitus patients with acute coronary syndrome. World J Diabetes 2024; 15(1): 34-42 [PMID: 38313856 DOI: 10.4239/wjd.v15.i1.34]
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"I read with great interest the systematic review of Wang and Liu regarding the impact of frailty on outcomes of elderly patients undergoing percutaneous coronary intervention (PCI). The authors conducted a systematic meta-analysis based on the well established PRISMA guidelines. A total of 739693 elderly patients undergoing PCI were included in the meta-analysis. Frail patients had significantly higher risks of in-hospital mortality, all-cause mortality, MACEs, and major bleeding compared to non-frail patients. Understanding that frailty significantly contributes to worse outcomes in elderly patients undergoing percutaneous coronary intervention (PCI) provides valuable insights for optimizing the care and outcomes of this vulnerable population. "
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Wang SS, Liu WH. Impact of frailty on outcomes of elderly patients undergoing percutaneous coronary intervention: A systematic review and meta-analysis. World J Clin Cases 2024; 12(1): 107-118 [PMID: 38292628 DOI: 10.12998/wjcc.v12.i1.107]
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"With the development of society, the incidence of fatty liver is increasing. Lipid metabolism is very important. The thesis is novel, detailed and worth reading."
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Li Y, Lee W, Zhao ZG, Liu Y, Cui H, Wang HY. Fatty acid binding protein 5 is a novel therapeutic target for hepatocellular carcinoma. World J Clin Oncol 2024; 15(1): 130-144 [PMID: 38292656 DOI: 10.5306/wjco.v15.i1.130]
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"This editorial manuscript highlights the negative effects of excessive insulin therapy, a long-standing issue in diabetes research.
However, both short-term and long-term complications of insulin overuse are often overlooked by health providers, particularly in adults with Type 2 Diabetes. Therefore this editorial is a welcome reminder of the potential complications of overinsulinization and a
strong recommendation to individualize insulin therapy plans and goals and to combine non-insulin diabetes medication early in the treatment plan
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Hu Y, Chen HJ, Ma JH. Individualized intensive insulin therapy of diabetes: Not only the goal, but also the time. World J Diabetes 2024; 15(1): 11-14 [PMID: 38313848 DOI: 10.4239/wjd.v15.i1.11]
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"The article is novel ，detailed and worth reading!"
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Shaikh SS, Qazi-Arisar FA, Nafay S, Zaheer S, Shaikh H, Azam Z. Metabolic puzzle: Exploring liver fibrosis differences in Asian metabolic-associated fatty liver disease subtypes. World J Hepatol 2024; 16(1): 54-64 [PMID: 38313248 DOI: 10.4254/wjh.v16.i1.54]
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"This paper on the impact of prediabetes on major adverse cardiac and cerebrovascular events (MACCE) in atrial fibrillation patients offers evidence in support of the harmful impact of prediabetes amongst AF patients. It highlights the heightened endothelial dysfunction and inflammation when the two coexist and lead to additive effects. Though similar impact on MACCE in the presence of prediabetes in AF has been reported before, this document is probably the largest data to date which sheds light on this topic.
The paper however could be taken further to discover novel insights and findings in this regard. Here are my suggestions:-
1) Since the authors had the access to database, might as well have analysed the normal patients and diabetic patients also and compared them amongst each other to get Odds ratios of all normal/prediabetes and diabetes. This would have clarified certain questions the readers may have. Further, prediabetes has an annual rate of 5-10% transitioning into diabetes which could have influenced your results. Perhaps that was not taken into account here. Another was would have been to stratify the entire cohort with HBa1C levels.
2) The authors could have analysed the impact of metformin as some of prediabetes patients were likely to be on metformin. This could have answered whether it is the blood glucose control of other variables like inflammation, endothelial dysfunction or the comorbidities that are responsible for the harmful effects amongst prediabets.
3) Definition of prediabetes is necessary. It has not been mentioned here. Whether Hba1c alone or blood glucose samples were taken ?
4) Reason for early discharge after prediabetes has not been discussed. Comes as a surprise to me.
5) Certain typos can be fixed like ("24 sary discharge" in source of data, "On the hand those who revert to normal blood sugar levels experience a decreased risk of heart failure"; other is missing after on the ___ hand)
Apart from the limitations accepted by the authors, another drawback is that it only analysis data for hospitalised patients which were discharged subsequently. Since majority of our patients are ambulatory who may not have ever been admitted to the hospital, the findings of this study may not hold true."
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Desai R, Katukuri N, Goguri SR, Kothawala A, Alle NR, Bellamkonda MK, Dey D, Ganesan S, Biswas M, Sarkar K, Prattipati P, Chauhan S. Prediabetes: An overlooked risk factor for major adverse cardiac and cerebrovascular events in atrial fibrillation patients. World J Diabetes 2024; 15(1): 24-33 [PMID: 38313858 DOI: 10.4239/wjd.v15.i1.24]
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"This article explores the important aspects of cancer treatment from a new perspective."
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Du YH, Zhao JJ, Li X, Huang SC, Ning N, Chen GQ, Yang Y, Nan Y, Yuan L. Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification. World J Gastrointest Oncol 2024; 16(1): 30-50 [PMID: 38292852 DOI: 10.4251/wjgo.v16.i1.30]
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"The article is well-written and effectively explores the impact of Tai Chi on the management of diabetes. The comprehensive discussion provides valuable insights into the potential benefits of this practice. While the literature search is mentioned, incorporating a pictorial diagram could enhance the visual representation of the search process, thereby improving the overall clarity and accessibility of the information"
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Hamasaki H. Effects of Tai Chi in diabetes patients: Insights from recent research. World J Diabetes 2024; 15(1): 1-10 [PMID: 38313854 DOI: 10.4239/wjd.v15.i1.1]
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"The paper presents a well-written and insightful exploration of diabetes management through targeted gut microbiota therapy. The clarity of the writing and the depth of the explanations contribute significantly to the overall quality of the paper."
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Xu TC, Liu Y, Yu Z, Xu B. Gut-targeted therapies for type 2 diabetes mellitus: A review. World J Clin Cases 2024; 12(1): 1-8 [PMID: 38292634 DOI: 10.12998/wjcc.v12.i1.1]
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"The authors revealed the findings that predictive nursing intervention can effectively relieve the pain, reduce the incidence of complications, improve mood and stress response, and serve as a reference value for the nursing of women undergoing rapid mass transfusion during CS.
The authors concluded in their original research article that, the predictive nursing mode has better clinical effect on pregnant women with CS bleeding after short-term massive blood transfusion, and the probability of postoperative complications is less.
Thus it reduced the maternal complications and maternal mortality.
The authors efforts are appreciated."
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Cheng L, Li LP, Zhang YY, Deng F, Lan TT. Clinical nursing value of predictive nursing in reducing complications of pregnant women undergoing short-term massive blood transfusion during cesarean section. World J Clin Cases 2024; 12(1): 51-58 [PMID: 38292622 DOI: 10.12998/wjcc.v12.i1.51]
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"This article focuses on the related risk factors affecting the rupture of gastrointestinal stromal tumors, and the results show that pathological risk is one of the risk factors. Then the author analyzes the related factors affecting the pathological risk of patients with gastrointestinal stromal tumors. Using SPSS software to analyze the data, the results are reliable, and the analysis results provide valuable ideas for future clinical work. However, the results would have been more convincing if the study had included patients with stromal tumors of colon origin and a multicenter study with a larger sample size."
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Liu JZ, Jia ZW, Sun LL. Factors associated with gastrointestinal stromal tumor rupture and pathological risk: A single-center retrospective study. World J Radiol 2023; 15(12): 350-358 [PMID: 38179203 DOI: 10.4329/wjr.v15.i12.350]
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"Firstly, I think that the current symptoms of the patients mostly related with the UCTD. The past medical history of the patients has completely evaluated by the medical team to exclude the possibility that the current problem was related with the UCTD. The article also completely report the laboratory finding to exclude the UCTD as the cause of the SCI. Undoubtedly management for the patient."
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Oleson CV, Olsen AC, Shermon S. Spinal cord infarction attributed to SARS-CoV-2, with post-acute sequelae of COVID-19: A case report. World J Clin Cases 2023; 11(36): 8542-8550 [PMID: 38188200 DOI: 10.12998/wjcc.v11.i36.8542]
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"no other comments."
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Abu-El-Rub E, Almahasneh F, Khasawneh RR, Alzu'bi A, Ghorab D, Almazari R, Magableh H, Sanajleh A, Shlool H, Mazari M, Bader NS, Al-Momani J. Human mesenchymal stem cells exhibit altered mitochondrial dynamics and poor survival in high glucose microenvironment. World J Stem Cells 2023; 15(12): 1093-1103 [PMID: 38179215 DOI: 10.4252/wjsc.v15.i12.1093]
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"No other comments."
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Silva MDVD, Piva M, Martelossi-Cebinelli G, Stinglin Rosa Ribas M, Hoffmann Salles Bianchini B, K Heintz O, Casagrande R, Verri Jr WA. Stem cells and pain. World J Stem Cells 2023; 15(12): 1035-1062 [PMID: 38179216 DOI: 10.4252/wjsc.v15.i12.1035]
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