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Reader Comments
Publication Name
Article Title
Year Published
"I am interested in reading an article with Cox II GA et al. Diagnostic reading of capsule endoscopy is challenging and has a consistent risk of readers missing significant findings. Currently, artificial intelligence (AI) has exceeded human image recognition abilities. The authors stated that artificial intelligence in VCE has improved GIAD detection. The diagnostic performance of a CADx algorithm, SSD, and ROI is almost over 90% of AUC on GIAD detection. I agree with their opinions. However, AI’s selection is based on the so-called “black box.” It is not easy to indicate the groups on the AI-decision made, and humans cannot understand it. The human physician can only answer, “the result is according to AI,” to the patient. As a result, the responsibility for diagnosis is unclear, and ethical issues must be resolved. In addition, current research is based on retrospective studies. Therefore, prospective studies using full-video capsule endoscopy and suitable DL architectures in multicenter settings are necessary. " 
Cox II GA, Jackson CS, Vega KJ. Artificial intelligence as a means to improve recognition of gastrointestinal angiodysplasia in video capsule endoscopy. Artif Intell Gastrointest Endosc 2021; 2(4): 179-184 [DOI: 10.37126/aige.v2.i4.179]
"The study demonstrates management of the locally advance rectal cancer. It is a nice article." 
Alvarez-Aguilera M, Jimenez-Rodriguez RM. Watch and wait in locally advance rectal cancer: Past, present and future. World J Meta-Anal 2021; 9(4): 327-332 [DOI: 10.13105/wjma.v9.i4.327]
"Suicidal thoughts and behaviors seem to be an important issue for spiritual and psychological practitioners around the world. A recent study showed that approximately half of the children who experienced suicidal thoughts and behaviors in adolescence first exhibited STBs in early childhood and comprised a trajectory suggesting increasing STBs. The other half probably developed suicidal thoughts and behaviors in early adolescence[1]. In addition to major depression, a mental illness with a high incidence among adolescents, subthreshold-depression and subthreshold-anxiety are also significantly associated with an increased suicide risk of adolescence[2]. Thus, Early screening and identification of at-risk youth during both preschool and late childhood is important for early intervention regarding Suicidal thoughts and behaviors. In China, we also face such serious problems. According to a recent study of China's continental regions, being a female and coming from a rural area are still potential risk factors for developing depressive traits among adolescent students in China[3]. How to reduce the self-injury and suicide behavior of adolescents with depression and adopt effective treatment methods has always been a difficult problem for doctors and their families. No pharmacotherapy alone was more effective than psychotherapy alone. Babeva et al [4] affirmed the potential value of personalized treatment approaches based on pretreatment characteristics. Zhou X et al[5] reported that only fluoxetine plus CBT and fluoxetine were significantly more effective than pill placebo or psychological controls, and only interpersonal therapy was more effective than all psychological controls. However, they also acknowledged that the effects of these interventions might vary between individuals. Due to the harmfulness of self-injury-suicide and the possibility of irreparable consequences, how to treat it quickly and effectively is also the concern of researchers. This paper, from researchers in Israel, offers a way to do it,In addition, the procedures and methods of Interpersonal psychotherapy for Adolescents (IPT-A) are illustrated in the form of individual cases, which is more practical. Interpersonal relationship has always been a major area of adolescent psychological problems, including the relationship with family members, friends, classmates, teachers, lovers and so on. In addition, there is something to be noted that, beginning in the teenage years, adolescents become less reliant on their parents for support and begin to turn to their peer group for support. Interpersonal psychotherapy for adolescents is an effective intervention for adolescent depression, improving a range of relevant outcomes. IPT-A may be particularly beneficial for adolescents who report a high level of avoidant attachment. However, IPT-A lacks an advantage in improving interpersonal difficulties[6], and has a weak effect on the prevention of adolescent depression[7]. Therefore, although IPT-A is recommended as A psychological treatment for adolescent depression, more clinical practice is needed to confirm it. In previous IPT-A studies, the treatment duration was about 10 weeks, while the ultra-short-term IPTA treatment duration was about 5 weeks. The specific clinical effect and the duration of the curative effect need to be verified by large-sample studies. All in all, as a psychiatrist who treats many children and adolescents with depression, this study may provide me with a more practical method for my work, however, further large sample studies are needed for clinical effectiveness. References [1] Whalen DJ, Hennefield L, Elsayed NM, Tillman R, Barch DM, Luby JL. Trajectories of Suicidal Thoughts and Behaviors From Preschool Through Late Adolescence. J Am Acad Child Adolesc Psychiatry 2021; S0890-8567(21)01364-2. Epub ahead of print. doi: 10.1016/j.jaac.2021.08.020. PMID: 34506928. [2] Balázs J, Miklósi M, Keresztény A, Hoven CW, Carli V, Wasserman C, Apter A, Bobes J, Brunner R, Cosman D, Cotter P, Haring C, Iosue M, Kaess M, Kahn JP, Keeley H, Marusic D, Postuvan V, Resch F, Saiz PA, Sisask M, Snir A, Tubiana A, Varnik A, Sarchiapone M, Wasserman D. Adolescent subthreshold-depression and anxiety: psychopathology, functional impairment and increased suicide risk. J Child Psychol Psychiatry 2013; 54(6):670-7. doi: 10.1111/jcpp.12016. PMID: 23330982. [3] Chen W, Huang Y, Riad A. Gender Differences in Depressive Traits among Rural and Urban Chinese Adolescent Students: Secondary Data Analysis of Nationwide Survey CFPS. Int J Environ Res Public Health 2021; 18(17):9124. doi: 10.3390/ijerph18179124. PMID: 34501714. [4] Babeva KN, Klomhaus AM, Sugar CA, Fitzpatrick O, Asarnow JR. Adolescent Suicide Attempt Prevention: Predictors of Response to a Cognitive-Behavioral Family and Youth Centered Intervention. Suicide Life Threat Behav 2020; 50(1):56-71. doi: 10.1111/sltb.12573. PMID: 31350782. [5] Zhou X, Teng T, Zhang Y, Del Giovane C, Furukawa TA, Weisz JR, Li X, Cuijpers P, Coghill D, Xiang Y, Hetrick SE, Leucht S, Qin M, Barth J, Ravindran AV, Yang L, Curry J, Fan L, Silva SG, Cipriani A, Xie P. Comparative efficacy and acceptability of antidepressants, psychotherapies, and their combination for acute treatment of children and adolescents with depressive disorder: a systematic review and network meta-analysis. Lancet Psychiatry 2020; 7(7):581-601. doi: 10.1016/S2215-0366(20)30137-1. PMID: 32563306. [6] Duffy F, Sharpe H, Schwannauer M. Review: The effectiveness of interpersonal psychotherapy for adolescents with depression - a systematic review and meta-analysis. Child Adolesc Ment Health 2019; 24(4):307-317. doi: 10.1111/camh.12342. PMID: 32677350. [7] Hetrick SE, Cox GR, Witt KG, Bir JJ, Merry SN. Cognitive behavioural therapy (CBT), third-wave CBT and interpersonal therapy (IPT) based interventions for preventing depression in children and adolescents. Cochrane Database Syst Rev 2016; 2016(8):CD003380. doi: 10.1002/14651858.CD003380.pub4. PMID: 27501438; PMCID: PMC8407360. " 
Klomek AB, Catalan LH, Apter A. Ultra-brief crisis interpersonal psychotherapy based intervention for suicidal children and adolescents. World J Psychiatr 2021; 11(8): 403-411 [PMID: 34513604 DOI: 10.5498/wjp.v11.i8.403]
"Concisely written article I congratulate authors for their effort in writing the article" 
Sekulovski M, Simonska B, Peruhova M, Krastev B, Peshevska-Sekulovska M, Spassov L, Velikova T. Factors affecting complications development and mortality after single lung transplant. World J Transplant 2021; 11(8): 320-334 [PMID: 34447669 DOI: 10.5500/wjt.v11.i8.320]
"This was an interesting analysis of the research trends in the area of visual hallucinations. That PD & DLB emerged as the two fields of research was not surprising The contributions by Prof McKeith to the research on visual hallucinations in DLB are well known. I am surprised that delirium, particularly alcohol withdrawal delirium does not form a part of the list. Perhaps, research in this area is not quite as prolific." 
Zhong M, Wu Z, Jiang X, Shen B, Zhu J, Zhang L. Knowledge domain and emerging trends in visual hallucination research: A scientometric analysis. World J Psychiatr 2021; 11(8): 491-506 [PMID: 34513610 DOI: 10.5498/wjp.v11.i8.491]
"Excellent review article. The authors could also present the most recent guidelines regarding imaging in sports medicine (in the form of a table)." 
Palermi S, Serio A, Vecchiato M, Sirico F, Gambardella F, Ricci F, Iodice F, Radmilovic J, Russo V, D'Andrea A. Potential role of an athlete-focused echocardiogram in sports eligibility. World J Cardiol 2021; 13(8): 271-297 [DOI: 10.4330/wjc.v13.i8.271]
"The authors demonstrated that the treatment of acute cholecystitis through papillary gallbladder drainage is both effective and safe for inoperable patients. This paper can be important evidence of clinical practice." 
Jandura DM, Puli SR. Efficacy and safety of endoscopic transpapillary gallbladder drainage in acute cholecystitis: An updated meta-analysis. World J Gastrointest Endosc 2021; 13(8): 345-355 [PMID: 34512882 DOI: 10.4253/wjge.v13.i8.345]
"It is an excellent and informative review article. The authors could present in details, in my opinion, the recent guidelines regarding the diagnosis of IE, such as in the form of a new table/figure. " 
Lo Presti S, Elajami TK, Zmaili M, Reyaldeen R, Xu B. Multimodality imaging in the diagnosis and management of prosthetic valve endocarditis: A contemporary narrative review. World J Cardiol 2021; 13(8): 254-270 [DOI: 10.4330/wjc.v13.i8.254]
"It is an important scientific paper which sheds light to a critical question that concerns patients undergoing TAVI. Indeed, further studies are needed in order to classify patients that would benefit more from a late coronary intervention than a preemptive approach. I have not any specific comments for the authors." 
Beska B, Manoharan D, Mohammed A, Das R, Edwards R, Zaman A, Alkhalil M. Role of coronary angiogram before transcatheter aortic valve implantation. World J Cardiol 2021; 13(8): 361-371 [DOI: 10.4330/wjc.v13.i8.361]
"It is a well written manuscript which sheds light in a confusing topic of Cardiology. I would not suggest any other comments." 
Vidal-Perez R, Bouzas-Mosquera A, Peteiro J, Vazquez-Rodriguez JM. ISCHEMIA trial: How to apply the results to clinical practice. World J Cardiol 2021; 13(8): 237-242 [DOI: 10.4330/wjc.v13.i8.237]
"In general it is a well written manuscript which covers an important topic of interest. Nevertheless, I think that the authors should take into consideration possible confounders such as liver dysfunction or other prothrombotic states or make a separate analysis regarding the use of antiplatelets and anticoagulants in order to eliminate confounders (if possible). Moreover, in the segment of discussion, they could enrich the mechanisms of thrombosis. " 
Kaewput W, Thongprayoon C, Rangsin R, Bathini T, Mao MA, Cheungpasitporn W. Associations of new-onset atrial fibrillation and severe visual impairment in type 2 diabetes: A multicenter nationwide study. World J Cardiol 2021; 13(8): 372-380 [DOI: 10.4330/wjc.v13.i8.372]
"In general, it is a well written manuscript. You could also mention the importance of pharmacogenomics and specifically resistance to clopidogrel/polymorphisms of CYP enzymes regarding thrombosis and bleeding post coronary artery stenting. " 
Han J, Attar N. Shortened dual antiplatelet therapy in contemporary percutaneous coronary intervention era. World J Cardiol 2021; 13(8): 243-253 [DOI: 10.4330/wjc.v13.i8.243]
"1. You could also describe in short the standard of care for patients with HF (pharmacologic and non-pharmacologic options) according to the most recent guidelines. 2. In the segment of introduction (1st paragraph) please provide better classification of HF syndromes (acute, chronic, diastolic, systolic, classification according to etiology-structural/functional causes). 3. At figure 2, please change the schemes of valsartan/sacubitril in order to "bind" appropriately to their molecular targets. 4. At figure 3, please correct spelling errors (ACD--> ICD, NYHA VI--> NYHA IV)." 
Usuda D, Higashikawa T, Hotchi Y, Usami K, Shimozawa S, Tokunaga S, Osugi I, Katou R, Ito S, Yoshizawa T, Asako S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Oba J, Nomura T, Sugita M. Angiotensin receptor blocker neprilysin inhibitors. World J Cardiol 2021; 13(8): 325-339 [DOI: 10.4330/wjc.v13.i8.325]
"It is in general a well-written manuscript. Nevertheless, there are a few limitations such as the use of ICDs for the detection of the patients/controls, the lack of control for other classic cardiovascular risk factors (ex. family history of CVD, exercise) and other personal characteristics (ex. income, educational status, alcohol consumption, other sources of social support, employment status etc). Moreover, a separate sub-analysis of the impact of certain psychiatric disorders on TTS would be of interest, is possible." 
Appiah D, Farias R, Helo D, Appiah L, Olokede OA, Nwabuo CC, Nair N. Association of marital status with takotsubo syndrome (broken heart syndrome) among adults in the United States. World J Cardiol 2021; 13(8): 340-347 [DOI: 10.4330/wjc.v13.i8.340]
"1. You could make grammatic/syntax improvements of the manuscript. 2. You could enrich the quality of the figures (ex. present mechanisms in detail). 3. You could describe mechanisms of disease in detail, whenever possible. 4. You should use references in every sentence. 5. You could present the mechanisms of function of LVAD as well as ECMO in details. 6. You could also present current evidence/knowledge about the use of HF medications in patients with COVID-19. " 
Raffaello WM, Huang I, Budi Siswanto B, Pranata R. In-depth review of cardiopulmonary support in COVID-19 patients with heart failure. World J Cardiol 2021; 13(8): 298-308 [DOI: 10.4330/wjc.v13.i8.298]
"This is a comprehensive review in the relevant topic and in the era of prolonged survival may lead to post-transplant complication which in turn can interfere transplant longevity and outcomes. Adding a table to summarize key characteristics of post-lung transplant complications can make readers grasp better core concept and for future citation. Complications related to COVID-19 in lung transplantation will be topic of interest to be add briefly in the article or subsequent work. " 
Sekulovski M, Simonska B, Peruhova M, Krastev B, Peshevska-Sekulovska M, Spassov L, Velikova T. Factors affecting complications development and mortality after single lung transplant. World J Transplant 2021; 11(8): 320-334 [PMID: 34447669 DOI: 10.5500/wjt.v11.i8.320]
"This article is well written . The emerging role of AI in RC is well presented. Technical details of DL in a simple way should have made the paper better. Most readers are not used to the software used in collection , extraction and segmentation. so a better explanation would have made the article even better. Overall the message came across very nicely. " 
Stanzione A, Verde F, Romeo V, Boccadifuoco F, Mainenti PP, Maurea S. Radiomics and machine learning applications in rectal cancer: Current update and future perspectives. World J Gastroenterol 2021; 27(32): 5306-5321 [DOI: 10.3748/wjg.v27.i32.5306]
"The Author does a good job putting up a concise review of mesenchymal therapy in COVID-19 infection. Author has explained the known pathogenesis in easy understanding way. As COVID -19 is still an evolving situation the true benefits of the treatment is still to be seen. It would have been interesting to see the effect of these therapies in pediatric population." 
Sütlüoğlu H, Özdemir Ö. May mesenchymal stem cell transplantation be a solution for COVID-19 induced cytokine storm? World J Transplant 2021; 11(8): 344-355 [PMID: 34447671 DOI: 10.5500/wjt.v11.i8.344]
"The author does a good job briefly outlining the markers used clinically in various stages of the GVHD. In my view it would have more beneficial if the author would have described in bit more detail the clinical utility of markers like their sensitivity/specificity and how they can effect clinical decision making. " 
Nagasawa M. Biomarkers of graft-vs-host disease: Understanding and applications for the future. World J Transplant 2021; 11(8): 335-343 [PMID: 34447670 DOI: 10.5500/wjt.v11.i8.335]
"The application of AI in microbiome is very important. This is an interesting study." 
Li ZM, Zhuang X. Application of artificial intelligence in microbiome study promotes precision medicine for gastric cancer. Artif Intell Gastroenterol 2021; 2(4): 105-110 [DOI: 10.35712/aig.v2.i4.105]
"The authors were very successful in using an interesting term of Endo-hepatology, however, there are still many uses of EUS in hepatology that they were not mentioned. As regarding the usage of endoscopic SWE as a non-invasive tool for measurement of fibrosis, it was not as successful as we have many other non-invasive tools (e.g fibroscan, CAP) rather than endoscopy that is much safer. EUS-guided paracentesis (EUS-P) is still not a practical issue. There are also some very important and useful uses for EUS that are not mentioned as the feasibility in the detection of small hepatic lesions that could be missed by other imaging modalities and the possibility of biopsy from those lesions. " 
Hogan DE, Ma M, Kadosh D, Menon A, Chin K, Swaminath A. Endo-hepatology: An emerging field. World J Gastrointest Endosc 2021; 13(8): 296-301 [PMID: 34512877 DOI: 10.4253/wjge.v13.i8.296]
"The authors report the effects of dietary natural products on gut microbiota and associated mechanisms in diabetes mellitus, however the authors describe the fruits, vegetables, herbs, and other plant foods. Why the author does not mention animal or fish products. e.g. milk, kefir, products with omega acids or vitamin D, " 
Xia F, Wen LP, Ge BC, Li YX, Li FP, Zhou BJ. Gut microbiota as a target for prevention and treatment of type 2 diabetes: Mechanisms and dietary natural products. World J Diabetes 2021; 12(8): 1146-1163 [PMID: 34512884 DOI: 10.4239/wjd.v12.i8.1146]
"The conclusion about the effects of melatonin in sleep is thought-provoking due the role of sleep in the evolution of schizophrenia. The results reported raise the relevance of use new methodologies to analyze data, for instance network analysis. This could help to clarify the relationship between symptoms in a complex system like shaped by psychotic symptoms. Reduction in sleep disturbances accountable for melatonin could lead to an improvement in cognitive function of people diagnosed with schizophrenia. This effect may be neglected by classical statistical methods." 
Duan C, Jenkins ZM, Castle D. Therapeutic use of melatonin in schizophrenia: A systematic review. World J Psychiatr 2021; 11(8): 463-476 [PMID: 34513608 DOI: 10.5498/wjp.v11.i8.463]
"The article is well-written, concise and easy to read. The topic debated is of a great interest for clinicians nowdays. Thank you." 
Norsa L, Bonaffini PA, Caldato M, Bonifacio C, Sonzogni A, Indriolo A, Valle C, Furfaro F, Bonanomi A, Franco PN, Gori M, Smania V, Scaramella L, Forzenigo L, Vecchi M, Solbiati M, Costantino G, Danese S, D'Antiga L, Sironi S, Elli L. Intestinal ischemic manifestations of SARS-CoV-2: Results from the ABDOCOVID multicentre study. World J Gastroenterol 2021; 27(32): 5448-5459 [DOI: 10.3748/wjg.v27.i32.5448]
"In this review, the authors described the diagnosis and treatment, especially EMR and ESD, for colorectal non-pedunculated polyps. In my opinion, the most important thing is an accurate qualitative and quantitative diagnosis of the lesion before treatment, although this may be assisted by AI in the future. In addition to this pre-treatment diagnosis, the treatment method should be chosen according to the size of the lesion and the skills of the endoscopists. From the viewpoint of accurate histopathological diagnosis and recurrence rate, en bloc resection of all lesions is desirable, but piecemeal resection may be acceptable for non-cancerous lesions. The treatment options may be different between Japan, where ESD was initially developed and is widely used in general practice, and Western countries, where ESD is not so widely used. However, the important thing is to provide the best medical care to patients in each environment, including the option of laparoscopic resection." 
Shahini E, Libânio D, Lo Secco G, Pisani A, Arezzo A. Indications and outcomes of endoscopic resection for non-pedunculated colorectal lesions: A narrative review. World J Gastrointest Endosc 2021; 13(8): 275-295 [PMID: 34512876 DOI: 10.4253/wjge.v13.i8.275]
"We appreciate Subho Chakrabarti’s review work and believe that this is a comprehensive paper for clozapine-resistant schizophrenia (CRS). I would like to raise two minor points. It is recommended that CRS is a subspecifier of treatment-resistant schizophrenia (TRS). Clinicians are recommended to exclude the possibility of nonadherence to clozapine (i.e., pseudo-resistance) and administer an adequate trial of clozapine. A diagnosis of CRS is made when blood levels of clozapine is ≥ 350 ng/mL; however, if obtaining blood samples is not feasible, a minimum dose of 500 mg/day is recommended. In the review article by Subho Chakrabarti, the adequate dose of clozapine (200 to 500 mg/day) in patients with CRS may be low. Besides, when assessing the available evidence for CRS, we need to exclude studies that were TRS but not CRS. For example, Subho Chakrabarti cited a study by Masoudzadeh and Khalillian[3] who compared clozapine, electroconvulsive therapy, and a combination of clozapine and electroconvulsive therapy. Patients in the clozapine group achieved a 40% reduction of the Positive and Negative Syndrome Scale scores. Therefore, participants in the study by by Masoudzadeh and Khalillian may be TRS but not CRS. " 
Chakrabarti S. Clozapine resistant schizophrenia: Newer avenues of management. World J Psychiatr 2021; 11(8): 429-448 [PMID: 34513606 DOI: 10.5498/wjp.v11.i8.429]
"This review contains very useful and comprehensive information about pancreatic tumors, which are rarely observed in childhood." 
Diaconescu S, Gîlcă-Blanariu GE, Poamaneagra S, Marginean O, Paduraru G, Stefanescu G. Could the burden of pancreatic cancer originate in childhood? World J Gastroenterol 2021; 27(32): 5322-5340 [DOI: 10.3748/wjg.v27.i32.5322]
"This review is the most comprehensive review I have read about liver complications, their diagnosis, and treatment of ICI, which has been increasingly used in cancer treatment in recent years. Thank you so much" 
Remash D, Prince DS, McKenzie C, Strasser SI, Kao S, Liu K. Immune checkpoint inhibitor-related hepatotoxicity: A review. World J Gastroenterol 2021; 27(32): 5376-5391 [DOI: 10.3748/wjg.v27.i32.5376]
"The results of this experimental study show that recombinant human angiopoietin-like protein 4 could be a promising therapeutic agent for intestinal ischemia/reperfusion-induced intestine injury. " 
Wang ZY, Lin JY, Feng YR, Liu DS, Zhao XZ, Li T, Li SY, Sun JC, Li SF, Jia WY, Jing HR. Recombinant angiopoietin-like protein 4 attenuates intestinal barrier structure and function injury after ischemia/reperfusion. World J Gastroenterol 2021; 27(32): 5404-5423 [DOI: 10.3748/wjg.v27.i32.5404]
"This review contains updated information about SPNN. As a pathologist, I think that this manuscript is very useful in emphasizing that these tumors should also be considered in the clinical differential diagnosis of pancreatic tumors. Thanks" 
Omiyale AO. Solid pseudopapillary neoplasm of the pancreas. World J Hepatol 2021; 13(8): 896-903 [DOI: 10.4254/wjh.v13.i8.896]
"This manuscript, which contains comprehensive and systematically valuable information on the pathogenesis of AIH, once again highlights how difficult the diagnosis of AIH is, both clinically and histopathologically. It also draws attention to how complex the current data are to detect a diagnostic tool. I wish the data associated with TIPE-2 were a bit more detailed." 
Fan JH, Liu GF, Lv XD, Zeng RZ, Zhan LL, Lv XP. Pathogenesis of autoimmune hepatitis. World J Hepatol 2021; 13(8): 879-886 [DOI: 10.4254/wjh.v13.i8.879]
"The authors compared the results of two different surgical methods (thoracoscopic-assisted surgery vs. transhiatal surgery) and concluded that thoracoscopic-assisted surgery has a better effect on early adenocarcinoma of the esophagus-gastric junction. There are some issues in the article that deserve attention. 1. The surgery data were collected from two medical centers, spanning 17 years, with a total of 147 operations. The average annual number of operations in each medical center is less than 5 cases. It is well known that the success rate of major surgery is related to the accumulation of surgical volume in medical units. For such a major operation, it is difficult to accumulate the surgeon's experience through this number of cases. It is difficult to guarantee the homogeneity of treatment in the two medical centers. 2. In most country, the application of thoracoscopy to the disease is later than transhiatal method. To a certain extent, the thoracoscopic technology is an improvement of transhiatal surgery. Because of better expose and more effective in mediastinal lymph nodes cleaning, more accurate tumor staging could be achieved. This can make the patient's subsequent adjuvant treatment selection more precise. If two different surgical methods are to be compared, the baseline data of the two groups of patients should be comparable. However, there is a significant difference in the age of the two groups of patients in the article, which shows that there is a serious selection bias in the treatment process. In addition, there is no data to prove that the tumor stages of the two groups of patients are comparable. The TNM staging of the tumor should be introduced. 3. In the introduction section of thoracoscopic surgery, there is no description of resection on the lymph nodes adjacent to the recurrent laryngeal nerve. In fact, the main cause of hoarseness is damage related with the recurrent laryngeal nerve. 4. The statistics on complications in the article are ambiguous. For example, atelectasis is statistically analyzed in respiratory complications and infections, which is unreasonable. 5. The data seem to be contradictory. The number of removed lymph nodes described in the article is inconsistent with that in Table 3. 6. The names of lymph nodes are confusing. In the outcome, there are named as resected lymph nodes (LDs) and lymph nodes affected (LA), which are changed to AL/DL in Table 3. By the way, the P value is also inconsistent with the table. 7. In the Long-term results section, the authors said "longer survival is observed in patients with earlier disease (up to stage 2B), undergoing thoracoscopic esophagectomy'. And they also said "The multivariable analysis demonstrated better results related to transhiatal access in early staging tumors, hazard ratio 1.73". This is contradictory. 8. The 10.9% incidence of respiratory complication in the discussion does not match the 14.8% in the table. 9. In the discussion, the complication of anastomotic fistula should actually be leakage, not fistula. Fistula and leakage are different. In addition, this complication does not require balloon expansion. Balloon dilatation is only considered for anastomotic stenosis. 10. The text and data in Table 4 are difficult to understand. It looks like two tables are merged to one. " 
Takeda FR, Obregon CA, Navarro YP, Moura DTH, Ribeiro Jr U, Aissar Sallum RA, Cecconello I. Thoracoscopic esophagectomy is related to better outcomes in early adenocarcinoma of esophagogastric junction tumors. World J Gastrointest Endosc 2021; 13(8): 319-328 [PMID: 34512879 DOI: 10.4253/wjge.v13.i8.319]
"The study design of the current study is confusing. The current study was published as a case control study and conducted in accordance with STROBE statement. However, the current study did not declare the study design type in the research and use "random", "ITT", and "PP" and several times in their manuscript." 
Choi YI, Chung JW, Kim KO, Kwon KA, Kim YJ, Kim JH, Seo JY, Park DK. Tailored eradication strategy vs concomitant therapy for Helicobacter pylori eradication treatment in Korean patients. World J Gastroenterol 2021; 27(31): 5247-5258 [PMID: 34497448 DOI: 10.3748/wjg.v27.i31.5247]
"Concise and easily readable article. The manuscript concerns a prospective study which in my opinion has some limitations and unfortunately these limitations lower its potential importance. 1) as mentioned by the authors themselves, the sample of patients is small; 2) The average follow-up period is too short to be able to evaluate a recurrence of the disease or its progress in stages; 3) in the discussion the Authors make some hints to other treatment methods but in a short and superficial way; 4) The references are dated. On the basis of these limits, the manuscript does not reach levels of innovation, it remains of general interest and hardly quotable" 
Kothari TH, Bittner K, Kothari S, Kaul V. Prospective evaluation of the hemorrhoid energy treatment for the management of bleeding internal hemorrhoids. World J Gastrointest Endosc 2021; 13(8): 329-335 [PMID: 34512880 DOI: 10.4253/wjge.v13.i8.329]
"It is a very interesting study. The authors conducted a systematic and comprehensive retrospective evaluation on computed tomography similarities and discrepancies between coronavirus disease 2019 pneumonia and other pulmonary illness (Focusing on cancer patients),which have clinical significance. The article is well organized, logical, and informative, with some innovativeness, and no previous review was conducted to summarize this topic, and the language/clinical figures was also fine. If the author could update their work and summarize the latest studies (2020/10-2021/6) on this topic, the research significance would be higher. Thanks for their efforts on this good study. " 
Perrone F, Balbi M, Casartelli C, Buti S, Milanese G, Sverzellati N, Bersanelli M. Differential diagnosis of COVID-19 at the chest computed tomography scan: A review with special focus on cancer patients. World J Radiol 2021; 13(8): 243-257 [DOI: 10.4329/wjr.v13.i8.243]
"It's a nice detailed review. I will take an approach on how it could be better from a critical point of view. Abstract; 1-2 sentences can be added about diagnosis, preoperative follow-up, biopsy indication (?) and operation indication (management). The part of "Typically, these tumors express nuclear and/or cytoplasmic β-catenin. Almost all solid pseudopapillary neoplasms harbor mutations in exon 3 of CTNNB1, the gene encoding β-catenin" in the abstract could have been explained in the "differential diagnosis" section. Instead, its relationship with general inherited disease (FAP) could be mentioned in general. An algorithm could be useful in differential diagnosis. As a result, it has been a study that provides clear information to the reader. Congratulations to the authors." 
Omiyale AO. Solid pseudopapillary neoplasm of the pancreas. World J Hepatol 2021; 13(8): 896-903 [DOI: 10.4254/wjh.v13.i8.896]
"Growing evidence has revealed the potential of gut microbiota in host homeostatic functions and multiple physiological processes. Recent data suggests the associations between GM and various diseases, including immunological diseases and cancers. It's a relatively new area of gut microbiota and immune checkpoint inhibitors. This paper mainly focused on the faecal microbiota transplantation and discussed its efficacy on immune checkpoint inhibitors therapy against cancers. It is well-organized, give us a clear and more clinical trials would be helpful providing more information. In addition, in the first paragraph in Introduction, the last word "word" should be "world"." 
Kang YB, Cai Y. Faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer. World J Gastroenterol 2021; 27(32): 5362-5375 [DOI: 10.3748/wjg.v27.i32.5362]
"In this mini-review, the authors describe the utility of AI for the detection of dysplasia in Barrett's esophagus, the detection and diagnosis of colorectal polyps, and the evaluation of mucosa in ulcerative colitis, based on the latest findings. AI is a breakthrough technology in recent medicine and is expected to play an active role in various fields. In the future, the role of AI in the field of endoscopy will increase further. However, AI can tell us the answer, but not the process by which the answer was derived. Therefore, over-reliance on AI may stop the growth of abilities and skills for doctors, especially beginners. AI is only a supplementary tool and should not be relied on as a mainstay. It is because that it must be humans who make the diagnosis and decide the treatment policy. If we understand this and get along well with AI, AI can be a good partner for us in various situations. I look forward to further technological innovation in AI. " 
Correia FP, Lourenço LC. Artificial intelligence application in diagnostic gastrointestinal endoscopy - Deus ex machina? World J Gastroenterol 2021; 27(32): 5351-5361 [DOI: 10.3748/wjg.v27.i32.5351]
"1.The first line in Introduction, viz., Diabetes mellitus (DM) is characterized by hyperglycemia and insufficient insulin secretion and/or dysfunction, should be reworded as Diabetes mellitus (DM) is characterized by hyperglycemia and insufficient insulin secretion and/or insulin resistance, and beta-cell dysfunction. 2.The second section title, viz., ALTERNATION OF GUT MICROBIOTA IN T2DM, should read as ALTERATION OF GUT MICROBIOTA IN T2DM. 3.IN FIGURE 1, THERE IS MENTION OF WHITE/BROWN ADIPOSE TISSUE, WHAT ABOUT BEIGE OR BRITE (BROWN AND WHITE) ADIPOSE TISSUE? 4.Rapamycin is so named because it was isolated from an island called Rapa Nui by an Indian (Sehgal). 5.Well written and comprehensive with 136 references. 6.Some questions for the authors: A. So many articles have been written on gut microbiota and diabetes, yet none of the major diabetes guidelines mention the use of probiotics, prebiotics, or synbiotics to treat diabetes. Is it because we need more human data from RCCTs? How do you propose to get diabetes societies to include this topic in the next version of their guidelines? B. Just as there is glucotoxicity and lipotoxicity, what about amino acid toxicity? After all, diabetes is a metabolic disorder affecting all 3 macronutrients. " 
Xia F, Wen LP, Ge BC, Li YX, Li FP, Zhou BJ. Gut microbiota as a target for prevention and treatment of type 2 diabetes: Mechanisms and dietary natural products. World J Diabetes 2021; 12(8): 1146-1163 [PMID: 34512884 DOI: 10.4239/wjd.v12.i8.1146]
"1. Although the authors' goal was to evaluate the coronary arteries and clinical aspects of young and middle-aged male CHD patients, the publication did not specify an age range for the young and middle-aged groups. 2. The definition from several references: 2.1 "People between the ages of 40 and 60 are usually considered to be middle-aged." From https://www.collinsdictionary.com/ dictionary/english/middle-aged. 2.2 "Definition of middle age: the period of life from about 45 to about 64. From https://www.merriam-webster.com/dictionary/ middle%20age. 2.3 "Defined as being between the ages of 40 and 60. From https://www.britannica.com/science/middle-age. 3. In the manuscript, The patients’ ages ranged from 33 to 77 (60.63 ± 5.48) years, not in the range of middle-age group. 4. In table 1, the middle-age group (n = 55) was 71.36 ± 5.43 years, this was not the correct definition of middle age. 5. It's mean that the results were not represented the middle-age group of male poppulation." 
Peng KG, Yu HL. Characteristic analysis of clinical coronary heart disease and coronary artery disease concerning young and middle-aged male patients. World J Clin Cases 2021; 9(25): 7358-7364 [DOI: 10.12998/wjcc.v9.i25.7358]
" Indocyanine green (ICG) emits an infrared signal when excited by laser light in situ. This signal can be detected with a near-infrared fluorescence (NIF) camera. NIF imaging uses laser technology to activate an intravenously delivered agent, ICG, which rapidly binds to plasma proteins. This allows ICG to remain predominantly in the vasculature enabling visual assessment of blood flow and tissue perfusion, sentinel lymph node biopsy, and lymph node road mapping. In this issue of the World Journal of Gastroenterology, the review article by Zocola et al. highlights the role of NIF in colorectal surgery. They have reviewed the literature on the use of NIF for three main indications: estimation of intestinal vascularization to detect areas of poor perfusion to prevent anastomotic leakage; visualization of sentinal lymphatic drainage and peritoneal metastases; and examination of the ureter to reduce the risk of iatrogenic ureteral lesions in colorectal surgery. NIF in conjunction with ICG allows visualization of the microcirculation before development of the anastomosis, thereby allowing the surgeon to choose the point of transaction in an optimally perfused area. Zocola et al. have intensively reviewed the role of NIF in intraoperative assessment of bowel viability for prevention of anastomotic leaks. They assessed the findings of retrospective cohort and prospective randomized controlled studies and reviewed the effectiveness of NIF in reducing anastomotic leakage. Regarding the role of NIF with ICG in detecting metastatic lymph nodes, Zocola et al. reviewed studies on the identification of sentinel lymph nodes and mapping of additional lymph nodes outside the proposed resection margins to achieve curative radical lymphadenectomy. In addition to the studies described by Zocola et al., I would like to discuss some recent relevant literature. One of the issues related to radical lymphadenectomy in colorectal cancer is lateral pelvic node dissection (LPND), and the data on this procedure using NIF have been recently reported. Kim et al. [1] demonstrated a novel application of NIF using ICG during robotic total mesorectal excision (TME) with LPND to identify suspected lateral pelvic lymph nodes and prevent incomplete dissection. They injected ICG at a dose of 2.5 mg around the tumor transanally before surgery, and NIF imaging–guided robotic TME with lateral pelvic lymphadenectomy allowed the surgeon to identify lymph nodes and lymphatic flow of rectal cancer. Zhou et al. [2] compared patients who underwent TME and LPND with the NIF technique (n = 12) and those who received conventional TME and LPND without NIF-guided imaging (n = 30). They reported that the NIF group had significantly lower intraoperative blood loss (55.8 ± 37.5 mL vs 108.0 ± 52.7 mL, P = 0.003) and a significantly larger number of lateral pelvic nodes harvested (11.5 ± 5.9 vs 7.1 ± 4.8, P = 0.017), and lateral pelvic lymph nodes from two patients in the NIF group remained during LPND. Additionally, Park et al. [3] used the NIF technique for colorectal cancer surgery for D3 lymphadenectomy, especially for right-sided colon cancer. They injected ICG around the tumor for visualization of lymphatic flow and lymph nodes and demonstrated that the number of apical lymph nodes (14 vs. 7, p < 0.001) and total harvested lymph nodes (39 vs. 30, p = 0.003) were significantly higher in the NIF group than in the conventional group. When injected intravenously, ICG rapidly binds to plasma proteins and remains predominantly in the vasculature. Although this has not been mentioned in this review article, NIF angiography can be used to examine the vascular system. ICG can be easily injected into blood vessels during surgery allowing direct visual observation of vascular structure. Bae et al. [4] studied 11 patients who underwent robotic TME with preservation of the left colic artery for rectal cancer using the NIF technique. The optimal point of division was then chosen by the surgeon under NIF imaging, which facilitated identification of the left colic branch of the inferior mesenteric artery (IMA). NIF imaging was also used to identify the collateral vessels (arc of Riolan) around the inferior mesenteric vein in their study. The left colic artery branches mainly at the Griffith point (watershed), which is located in the splenic bend, where the left branch of the middle colic and the ascending branch of the left colic join. This area is vulnerable to intraoperative injury and ischemia due to poor blood supply. Therefore, great care must be taken to avoid injuring the bifurcation of the left colic artery. Real-time identification of collateral vessels using NIF technology can help perform safe low ligation of the IMA while preventing damage to these vessels. Currently, it remains a linear graded outcome that requires subjective interpretation of the demarcation point between sufficient and insufficient perfusion, and perfusion is assessed based on the subjective qualitative impression of the surgeon. Quantitative analysis of NIF images is desirable but is not currently available in robotic or laparoscopic systems. Son et al. [5] performed a quantitative evaluation of colon perfusion patterns using NIF angiography to identify the most reliable predictive factor of anastomotic complications after laparoscopic colorectal surgery. They found that the fluorescence slope, T1/2MAX, and time ratio were related to anastomotic complications, which were significantly correlated with the novel factor time ratio (> 0.6) as the most reliable predictor of perfusion and anastomotic complications. Recently, Han et al. [6] compared the changes in perfusion status between high tie and low tie through quantitative evaluation of ICG using NIF. They demonstrated that T_max increased and Slope_max decreased significantly in the high-tie group after IMA ligation, whereas the intensity of perfusion status (F_max), which indicates the intensity of perfusion, did not change according to the level of IMA ligation. They suggested that the speed of blood perfusion could be more delayed after high tie than after low tie, but the intensity of perfusion was similar between high and low ligation of the IMA. There are still many questions and debates requiring resolution, but we believe that the NIF technique will play an important role in improving the clinical and oncologic outcomes of colorectal surgery. References 1 Kim HJ, Park JS, Choi GS, Park SY, Lee HJ. Fluorescence-guided robotic total mesorectal excision with lateral pelvic lymph node dissection in locally advanced rectal cancer: A video presentation. Dis Colon Rectum 2017; 60(12): 1332-3. 2 Zhou SC, Tian YT, Wang XW et al. Application of indocyanine green-enhanced near-infrared fluorescence-guided imaging in laparoscopic lateral pelvic lymph node dissection for middle-low rectal cancer. World J Gastroenterol 2019; 25(31): 4502-11. 3 Park SY, Park JS, Kim HJ, Woo IT, Park IK, Choi GS. Indocyanine green fluorescence imaging-guided laparoscopic surgery could achieve radical D3 dissection in patients with advanced right-sided colon cancer. Dis Colon Rectum 2020; 63(4): 441-9. 4 Bae SU, Min BS, Kim NK. Robotic low ligation of the inferior mesenteric artery for rectal cancer using the firefly technique. Yonsei Med J 2015; 56(4): 1028-35. 5 Son GM, Kwon MS, Kim Y, Kim J, Kim SH, Lee JW. Quantitative analysis of colon perfusion pattern using indocyanine green (ICG) angiography in laparoscopic colorectal surgery. Surg Endosc 2019; 33(5): 1640-9. 6 Han SR, Lee CS, Bae JH et al. Quantitative evaluation of colon perfusion after high versus low ligation in rectal surgery by indocyanine green: A pilot study. Surg Endosc 2021. 1. Kim HJ, Park JS, Choi GS, Park SY, Lee HJ. Fluorescence-guided Robotic Total Mesorectal Excision with Lateral Pelvic Lymph Node Dissection in Locally Advanced Rectal Cancer: A Video Presentation. Dis Colon Rectum. 2017;60(12):1332-1333. 2. Zhou SC, Tian YT, Wang XW, Zhao CD, Ma S, Jiang J, et al. Application of indocyanine green-enhanced near-infrared fluorescence-guided imaging in laparoscopic lateral pelvic lymph node dissection for middle-low rectal cancer. World J Gastroenterol. 2019;25(31):4502-4511. 3. Park SY, Park JS, Kim HJ, Woo IT, Park IK, Choi GS. Indocyanine Green Fluorescence Imaging-Guided Laparoscopic Surgery Could Achieve Radical D3 Dissection in Patients With Advanced Right-Sided Colon Cancer. Dis Colon Rectum. 2020;63(4):441-449. 4. Bae SU, Min BS, Kim NK. Robotic Low Ligation of the Inferior Mesenteric Artery for Rectal Cancer Using the Firefly Technique. Yonsei Med J. 2015;56(4):1028-1035. 5. Son GM, Kwon MS, Kim Y, Kim J, Kim SH, Lee JW. Quantitative analysis of colon perfusion pattern using indocyanine green (ICG) angiography in laparoscopic colorectal surgery. Surg Endosc. 2019;33(5):1640-1649. 6. Han SR, Lee CS, Bae JH, Lee HJ, Yoon MR, Al-Sawat A, et al. Quantitative evaluation of colon perfusion after high versus low ligation in rectal surgery by indocyanine green: a pilot study. Surg Endosc. 2021. doi:10.1007/s00464-021-08673-x. " 
Zocola E, Meyer J, Christou N, Liot E, Toso C, Buchs NC, Ris F. Role of near-infrared fluorescence in colorectal surgery. World J Gastroenterol 2021; 27(31): 5189-5200 [PMID: 34497444 DOI: 10.3748/wjg.v27.i31.5189]
"This is a nice study." 
Polyak A, Kuo A, Sundaram V. Evolution of liver transplant organ allocation policy: Current limitations and future directions. World J Hepatol 2021; 13(8): 830-839 [DOI: 10.4254/wjh.v13.i8.830]
"I read with great interest the article on Antibiotic prophylaxis in patients with cirrhosis: Current evidence for clinical practice by Alberto Ferrarese et al. In this review article , authors have given an overview about the application of antibiotic prophylaxis in patients with cirrhosis according to the current evidence. Patients with cirrhosis, particularly those with decompensated cirrhosis, are at increased risk of bacterial infections that may further precipitate other liver decompensations including acute-on-chronic liver failure. Infections constitute the main cause of death in patients with advanced cirrhosis, and strategies to prevent them are essential. The main current strategy is the use of prophylactic antibiotics targeted at specific subpopulations at high risk of infection: prior episode of spontaneous bacterial peritonitis, upper gastrointestinal bleeding, and low-protein ascites with associated poor liver function. Antibiotic prophylaxis effectively prevents not only the development of bacterial infections in all these indications but also further decompensation (variceal bleeding, hepatorenal syndrome) and improves survival. However, antibiotic prophylaxis is also associated with a clinically relevant and increasing drawback, the development of infections due to multidrug-resistant organisms. Several strategies have been suggested to balance the risks and benefits of antibiotic prophylaxis. Antibiotic stewardship principles such as the restriction of antibiotic prophylaxis to subpopulations at a very high risk for infection, the avoidance of antibiotic overuse, and early deescalation policies are key to achieve this balance; nonantibiotic prophylactic measures such as probiotics, prokinetics, bile acids, statins, and hematopoietic growth factors could also contribute to ameliorate the development and spread of multidrug-resistant bacteria in cirrhosis. " 
Ferrarese A, Passigato N, Cusumano C, Gemini S, Tonon A, Dajti E, Marasco G, Ravaioli F, Colecchia A. Antibiotic prophylaxis in patients with cirrhosis: Current evidence for clinical practice. World J Hepatol 2021; 13(8): 840-852 [DOI: 10.4254/wjh.v13.i8.840]
"Read the review with great interest. Authors have discussed in detail regarding antibiotic prophylaxis in both elective as well as emergency procedures and complications of cirrhosis. The CANONIC study has shown infections as the most common precipitant of acute decompensation either alone or in combination leading to Acute-on-chronic Liver Failure. In addition, infections cause acute worsening of portal hypertension leading to increased risk of bleeding, HRS etc. Considering emergence of multi drug resistant infections, judicious use of antibiotics for prophylaxis should be explored. Rifaximin as a non-absorbable antibiotic has been a promising agent in HE with some data favoring use in SBP needs further studies. More studies are needed for secondary prophylaxis in patients with ACLF who had MDR infections to prevent future decompensations, especially when liver transplant is not feasible." 
Ferrarese A, Passigato N, Cusumano C, Gemini S, Tonon A, Dajti E, Marasco G, Ravaioli F, Colecchia A. Antibiotic prophylaxis in patients with cirrhosis: Current evidence for clinical practice. World J Hepatol 2021; 13(8): 840-852 [DOI: 10.4254/wjh.v13.i8.840]
"The authors have highlighted the possible multiple effects of immune impairment in the patients with diabetes and how the immune response to to COVID-19. It gives an idea about the diagnosis and treatment aspects of the of diabetic patients who suffered with COVID-19. And also it can be useful the development of remedial measures in treating for COVID-19 in individuals with diabetes. If the stages of the diabetes could be more informative to understand the concept in detail in future will be appreciated. " 
Lu ZH, Yu WL, Sun Y. Multiple immune function impairments in diabetic patients and their effects on COVID-19. World J Clin Cases 2021; 9(24): 6969-6978 [DOI: 10.12998/wjcc.v9.i24.6969]
"some abbreviations are not included once mentioned e.g. AVB, although VB (variceal bleeding is there), however AVB (whether Acute or Advanced) needed to be shown. " 
Ferrarese A, Passigato N, Cusumano C, Gemini S, Tonon A, Dajti E, Marasco G, Ravaioli F, Colecchia A. Antibiotic prophylaxis in patients with cirrhosis: Current evidence for clinical practice. World J Hepatol 2021; 13(8): 840-852 [DOI: 10.4254/wjh.v13.i8.840]
"This case report is well-written, and is informative for journal readers" 
Wu JD, Chen YX, Luo C, Xu FH, Zhang L, Hou XH, Song J. Plexiform angiomyxoid myofibroblastic tumor treated by endoscopic submucosal dissection: A case report and review of the literature. World J Gastroenterol 2021; 27(31): 5288-5296 [PMID: 34497451 DOI: 10.3748/wjg.v27.i31.5288]
"This review article is well-written, complete and good for further discussions" 
Weng CY, Xu JL, Sun SP, Wang KJ, Lv B. Helicobacter pylori eradication: Exploring its impacts on the gastric mucosa. World J Gastroenterol 2021; 27(31): 5152-5170 [PMID: 34497441 DOI: 10.3748/wjg.v27.i31.5152]
"This informative and well-written review article is good for further discussion" 
Young E, Philpott H, Singh R. Endoscopic diagnosis and treatment of gastric dysplasia and early cancer: Current evidence and what the future may hold. World J Gastroenterol 2021; 27(31): 5126-5151 [PMID: 34497440 DOI: 10.3748/wjg.v27.i31.5126]
"It is a review useful for multidisciplinary discussion." 
Velikova T, Snegarova V, Kukov A, Batselova H, Mihova A, Nakov R. Gastrointestinal mucosal immunity and COVID-19. World J Gastroenterol 2021; 27(30): 5047-5059 [PMID: 34497434 DOI: 10.3748/wjg.v27.i30.5047]