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Reader Comments
Publication Name
Article Title
Year Published
1
"Comments from Huanjie Li (lihuanjie@sdu.edu.cn) Helicobacter pylori, the major risk factor of gastric cancer, is categorized as a class I carcinogen. Recently,an increasing evidence suggests that the GIT (gastrointestinal tract) microbiota, especially the gastric microbiota affects health and disease. However, the molecular mechanism of the relationship between H. pylori infection, gastric microbiota and gastric cancer (GC) remains unclear. Based on recent studies, Liatsos, et al. attempted to summarize the impact of different factors including Hp-I on gastric microbiota composition to unroll the tangle regarding the interaction between Hp-I, GM and GC. The review showed that the perpetuation of Hp-I reduces microbiota diversity and is connected with atrophy, IM and GC. H. pylori entirely dominated the microbiota not only in infected patients but also in the majority of individuals categorized as H. pylori-infected using conventional approaches, thus implying an active role in all cases of GC development. It is more than clear that Hp-I, GM and GC constitute a challenging tangle due to the strong interaction between them making it difficult to unroll it. Beyond H. pylori’s role in gastric oncogenesis, other bacteria, H. pylori-stimulated or not, in GM also seem to be responsible for transformation of gastric epithelial cells. The review suggested that the maze of GC complex pathogenesis where abundant data showed that beyond H. pylori related gastritis, additional pathogens might contribute to this type of cancer development. Nevertheless, large-scale experiments are needed to discern the exact role of different kinds of pathogens which reside in the stomach and their contribution to neoplasia emergence, aiding in the prediction of adverse prognosis of a specific microbiota diversity. The mechanisms of H. pylori infection, GM and GC relationship are critical for the early diagnosis and treatment of GC. " 
Liatsos C, Papaefthymiou A, Kyriakos N, Galanopoulos M, Doulberis M, Giakoumis M, Petridou E, Mavrogiannis C, Rokkas T, Kountouras J. Helicobacter pylori, gastric microbiota and gastric cancer relationship: Unrolling the tangle. World J Gastrointest Oncol 2022; 14(5): 959-972 [DOI: 10.4251/wjgo.v14.i5.959]
2
"It is teaching that calcium supplementation on severe hypocalcemia in patients following secondary hyperparathyroidism after total parathyroidectomy is important. It gives an important implication in clincial." 
Liu J, Fan XF, Yang M, Huang LP, Zhang L. Effect of calcium supplementation on severe hypocalcemia in patients with secondary hyperparathyroidism after total parathyroidectomy. World J Clin Cases 2022; 10(13): 4033-4041 [DOI: 10.12998/wjcc.v10.i13.4033]
3
"CT imaging seemed challenging to preserve the spleen, so the operation was done well. As for rareness, many doctors would like to see the intraoperative photos and resected specimen. Paragraph of TREATMENT should be before pathological findings. " 
Ha FS, Liu H, Han T, Song DZ. Primary hepatic angiosarcoma manifesting as hepatic sinusoidal obstruction syndrome: A case report. World J Gastrointest Oncol 2022; 14(5): 1050-1056 [DOI: 10.4251/wjgo.v14.i5.1050]
4
" very interesting topic," 
Garbuzenko DV. Pathophysiological mechanisms of hepatic stellate cells activation in liver fibrosis . World J Clin Cases 2022; 10(12): 3662-3676 [DOI: 10.12998/wjcc.v10.i12.3662]
5
"Good" 
Zhang CC, Chen P. Anti-programmed death 1 antibody in the treatment of coexistent Mycobacterium fortuitum and lung cancer: A case report. World J Clin Cases 2022; 10(12): 3801-3807 [DOI: 10.12998/wjcc.v10.i12.3801]
6
"Authors made that the scientific community gradually realized the importance of the impact of IOL tilt and decentration on their quantification and the precision improvement of measurement methods. The usage of multifocal IOLs (MIOLs) and extended depth of focus (EDOF) IOLs is significantly higher than that in the past owing to the improvement in the quality of life. And it is necessary to clearly identify the causes of IOL tilt and decentration and their effects on the postoperative visual quality of different IOL eyes, especially trifocal and EDOF IOL eyes, guidance for selecting a proper IOL and determine the effective lens position for improving the postoperative visual effect of cataract patient was attempted to provide it. " 
Chen XY, Wang YC, Zhao TY, Wang ZZ, Wang W. Tilt and decentration with various intraocular lenses: A narrative review. World J Clin Cases 2022; 10(12): 3639-3646 [DOI: 10.12998/wjcc.v10.i12.3639]
7
"This is an interesting mini review. The prognostic impact of FIB-4, APRI etc was not mentioned" 
Elnaggar M, Abomhya A, Elkhattib I, Dawoud N, Doshi R. COVID-19 and liver diseases, what we know so far. World J Clin Cases 2022; 10(13): 3969-3980 [DOI: 10.12998/wjcc.v10.i13.3969]
8
"good" 
He T, Liu C, Lu ZX, Kong LL, Li Y, Xu Z, Dong YJ, Hao W. Effect of wrist-ankle acupuncture on propofol dosage during painless colonoscopy: A randomized controlled prospective study. World J Clin Cases 2022; 10(12): 3764-3772 [DOI: 10.12998/wjcc.v10.i12.3764]
9
"good" 
Shi YC, Li J, Li SJ, Li ZP, Zhang HJ, Wu ZY, Wu ZY. Flap failure prediction in microvascular tissue reconstruction using machine learning algorithms. World J Clin Cases 2022; 10(12): 3729-3738 [DOI: 10.12998/wjcc.v10.i12.3729]
10
"good" 
Ding F, Chen RY, Hou J, Guo J, Dong TY. Efficacy and prognostic factors of neoadjuvant chemotherapy for triple-negative breast cancer. World J Clin Cases 2022; 10(12): 3698-3708 [DOI: 10.12998/wjcc.v10.i12.3698]
11
"good" 
Garbuzenko DV. Pathophysiological mechanisms of hepatic stellate cells activation in liver fibrosis . World J Clin Cases 2022; 10(12): 3662-3676 [DOI: 10.12998/wjcc.v10.i12.3662]
12
"good" 
Chen XY, Wang YC, Zhao TY, Wang ZZ, Wang W. Tilt and decentration with various intraocular lenses: A narrative review. World J Clin Cases 2022; 10(12): 3639-3646 [DOI: 10.12998/wjcc.v10.i12.3639]
13
"Good" 
Li ZP, Xu DH, He LP, Wang XJ. Fuzhuan brick tea affects obesity process by modulating gut microbiota. World J Gastrointest Pharmacol Ther 2022; 13(3): 30-32 [DOI: 10.4292/wjgpt.v13.i3.30]
14
"This is an interesting paper but in small cohort. FIB-4 was not included in multi analysis. The latter should be COX providing HR and not OR" 
Madian A, Eliwa A, Abdalla H, A Azeem Aly H. Aspartate transferase-to-platelet ratio index-plus: A new simplified model for predicting the risk of mortality among patients with COVID-19. World J Gastroenterol 2022; 28(16): 1671-1680 [PMID: 35581967 DOI: 10.3748/wjg.v28.i16.1671]
15
"This review summarizes the state-of-the-art artificial intelligence( AI) in the endoscopic diagnosis and treatment of biliary diseases. It is a well-written and useful article. However, almost all AI-related articles are retrospective studies. Prospective studies are desirable in the future in this field of study. " 
Correia FP, Lourenço LC. Artificial intelligence in the endoscopic approach of biliary tract diseases: A current review. Artif Intell Gastrointest Endosc 2022; 3(2): 9-15 [DOI: 10.37126/aige.v3.i2.9]
16
"We know the dietary intervention a little more specific to the SARS-CoV-2 virus infection. References: PMID: 35126592 by Ikeda et al, and PMID: 33042496 by murakami et al." 
Wang MK, Yu XL, Zhou LY, Si HM, Hui JF, Hou DY, Li WP, Yang JS. COVID-19 and liver dysfunction: What nutritionists need to know. World J Gastroenterol 2022; 28(15): 1526-1535 [PMID: 35582132 DOI: 10.3748/wjg.v28.i15.1526]
17
"It was possible to estimate the therapeutic potential of immunotherapy targeting colorectal cancer, classified as a cold tumor. Very interesting." 
Xu YJ, Zhang P, Hu JL, Liang H, Zhu YY, Cui Y, Niu P, Xu M, Liu MY. Regorafenib combined with programmed cell death-1 inhibitor against refractory colorectal cancer and the platelet-to-lymphocyte ratio’s prediction on effectiveness. World J Gastrointest Oncol 2022; 14(4): 920-934 [PMID: 35582108 DOI: 10.4251/wjgo.v14.i4.920]
18
"Information on the vasoactive intestinal peptide secreting tumour is well documented. Very helpful." 
Una Cidon E. Vasoactive intestinal peptide secreting tumour: An overview. World J Gastrointest Oncol 2022; 14(4): 808-819 [PMID: 35582098 DOI: 10.4251/wjgo.v14.i4.808]
19
"Very interesting and innovative topic. The review, although very long, is pleasant to read, complete, well organized and offers a complete picture of the subject. There are many references and well organized." 
Christou CD, Tsoulfas G. Role of three-dimensional printing and artificial intelligence in the management of hepatocellular carcinoma: Challenges and opportunities. World J Gastrointest Oncol 2022; 14(4): 765-793 [PMID: 35582107 DOI: 10.4251/wjgo.v14.i4.765]
20
"nowadays the number of long-surviving cancer patients is constantly increasing, and often medical oncologists face oligometastatic disease. Single pulmonary metastasis from colorectal cancer is a not frequent situation in which diagnostic pitfalls should be considered. Surgery more than radiotherapy or ablative procedures might have a theoretical curative role with rewarding long-term results. The authors undeline that the best long-term results might be expected by combination of loco-regional with chemotherapy and systemic treatment. It seems necessary to address all aspects of the disease, the physical condition of the patients and the presence of other metastatic sites before opting for a therapeutic treatment because many factors seem to modify prognosis in this subset of patients and should be considered when planning a personalized care option. Chiappetta M, Salvatore L, Congedo MT, Bensi M, De Luca V, Petracca Ciavarella L, Camarda F, Evangelista J, Valentini V, Tortora G, Margaritora S, Lococo F. Management of single pulmonary metastases from colorectal cancer: State of the art. World J Gastrointest Oncol 2022; 14(4): 820-832 [DOI: 10.4251/wjgo.v14.i4.820]" 
Chiappetta M, Salvatore L, Congedo MT, Bensi M, De Luca V, Petracca Ciavarella L, Camarda F, Evangelista J, Valentini V, Tortora G, Margaritora S, Lococo F. Management of single pulmonary metastases from colorectal cancer: State of the art. World J Gastrointest Oncol 2022; 14(4): 820-832 [PMID: 35582100 DOI: 10.4251/wjgo.v14.i4.820]
21
"The role of ncRNAs in CRC stem cells are well described in the article." 
Chao HM, Wang TW, Chern E, Hsu SH. Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells. World J Gastrointest Oncol 2022; 14(4): 748-764 [PMID: 35582099 DOI: 10.4251/wjgo.v14.i4.748]
22
"Authors should mention something about the effect of estrogen in addition to that of progesterone on the composition of gut microbiota during pregnancy." 
Liu ZZ, Sun JH, Wang WJ. Gut microbiota in gastrointestinal diseases during pregnancy. World J Clin Cases 2022; 10(10): 2976-2989 [DOI: 10.12998/wjcc.v10.i10.2976]
23
"Very good manuscript." 
Akiyama S, Sakamoto T, Steinberg JM, Saito Y, Tsuchiya K. Evolving roles of magnifying endoscopy and endoscopic resection for neoplasia in inflammatory bowel diseases. World J Gastrointest Oncol 2022; 14(3): 646-653 [PMID: 35321277 DOI: 10.4251/wjgo.v14.i3.646]
24
"I read the paper with an open mind and discovered that the content was updated and valuable to the readers. I am hopeful that the authors will conduct advanced study in this topic for our scientific community in the near future." 
Currais P, Rosa I, Claro I. Colorectal cancer carcinogenesis: From bench to bedside. World J Gastrointest Oncol 2022; 14(3): 654-663 [PMID: 35321283 DOI: 10.4251/wjgo.v14.i3.654]
25
"The article gives updated information on the epidemiology of stomach cancer. It is worth reading it." 
Ilic M, Ilic I. Epidemiology of stomach cancer. World J Gastroenterol 2022; 28(12): 1187-1203 [PMID: 35431510 DOI: 10.3748/wjg.v28.i12.1187]
26
"The authors of this article explore mesenchymal stem cells (MSCs) as a promising adjunctive therapy for alleviating acute lung injury and cytokine storms associated with COVID-19. The authors mention that in some published studies, MSCs have been used to mitigate COVID-19-related acute lung injury and cytokine storms with promising results. However, this evidence came from a single case report, with a small number of participants in the study. Therefore, more studies are needed to validate the role of MSCS." 
Pawitan JA. Mesenchymal stem/stromal cells as adjuvant therapy in COVID-19-associated acute lung injury and cytokine storm: Importance of cell identification. World J Stem Cells 2022; 14(3): 264-266 [PMID: 35432737 DOI: 10.4252/wjsc.v14.i3.264]
27
"Myelosuppression is one of the most common side effects of radiation therapy and the leading cause of death after irradiation. Our team has shown that multiple transplantation stromal cells (ADSCs) of adipose-derived mesenchymal cells delay the regeneration of bone marrow hematopoietic stem cells. ADSCs administered at optimal doses improve survival after total body irradiation. This opens up new possibilities for future clinical treatment." 
Kim MJ, Moon W, Heo J, Lim S, Lee SH, Jeong JY, Lee SJ. Optimization of adipose tissue-derived mesenchymal stromal cells transplantation for bone marrow repopulation following irradiation. World J Stem Cells 2022; 14(3): 245-263 [PMID: 35432736 DOI: 10.4252/wjsc.v14.i3.245]
28
"The authors focused on whether pork-urine-derived induced pluripotent stem cells (piPSCs) could facilitate their routine and large-scale use by avoiding injury or stress during autologous specimen collection. But the precise reprogramming process and its properties have not been fully elucidated in species other than mice or humans." 
Recchia K, Machado LS, Botigelli RC, Pieri NCG, Barbosa G, de Castro RVG, Marques MG, Pessôa LVF, Fantinato Neto P, Meirelles FV, Souza AF, Martins SMMK, Bressan FF. In vitro induced pluripotency from urine-derived cells in porcine. World J Stem Cells 2022; 14(3): 231-244 [PMID: 35432738 DOI: 10.4252/wjsc.v14.i3.231]
29
"Schizophrenia (SCZ) is a devastating and complex mental disorder with multiple positive and negative symptoms and cognitive deficits. In this review, the authors mention hippo campal neural stem cells, key components of adult SCZ risk genes and related signaling pathways, as well as their role in adult neurogenesis and animal behavior, which provide new possibilities for future treatment of SCZ." 
Hu L, Zhang L. Adult neural stem cells and schizophrenia. World J Stem Cells 2022; 14(3): 219-230 [PMID: 35432739 DOI: 10.4252/wjsc.v14.i3.219]
30
"D-amino acids produced by specific microbiota could regulate or contribute to the pathogenesis of IBS. Anyway, we agree novel microbiota-based strategies for the IBS need to be definitely explored." 
Mamieva Z, Poluektova E, Svistushkin V, Sobolev V, Shifrin O, Guarner F, Ivashkin V. Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations? World J Gastroenterol 2022; 28(12): 1204-1219 [PMID: 35431513 DOI: 10.3748/wjg.v28.i12.1204]
31
"Adenomatous polyposis coli (APC) is the most commonly mutated genes found in colorectal cancers. In addition, the Wnt signaling activation after the loss of the APC is assumed to be the important event for the cancer initiation. Authors should mention more about the above." 
Majumder S, Shivaji UN, Kasturi R, Sigamani A, Ghosh S, Iacucci M. Inflammatory bowel disease-related colorectal cancer: Past, present and future perspectives. World J Gastrointest Oncol 2022; 14(3): 547-567 [PMID: 35321275 DOI: 10.4251/wjgo.v14.i3.547]
32
"It provides a new method for the treatment of gastroesophageal reflux disease and it is very interesting. More investigations into adverse effects will be needed clinically." 
Xu LY, Yu BY, Cen LS. New treatment for gastroesophageal reflux disease: Traditional Chinese medicine Xiaochaihu decoction. World J Gastroenterol 2022; 28(11): 1184-1186 [PMID: 35431502 DOI: 10.3748/wjg.v28.i11.1184]
33
" This study explored the correlation between the betatrophin/ angiogenin-likeprotein3 (ANGPTL3) / lipoprotein lipase (LPL) pathway and severity of coronary artery disease in Kazakh descent and Han descent patients with CHD. This study found that a correlation between the betatrophin/ANGPTL3/LPL pathway and severity of CAD in patients with CHD. At the some time, This study found that TG and betatrophin were the risk factors of coronary artery disease in Kazakh patients, while BMI and betatrophin were the risk factors in Han patients. It suggests that we should also pay attention to ethnic differences in the study of coronary heart disease." 
Qin L, Rehemuding R, Ainiwaer A, Ma X. Correlation between betatrophin/angiogenin-likeprotein3/lipoprotein lipase pathway and severity of coronary artery disease in Kazakh patients with coronary heart disease. World J Clin Cases 2022; 10(7): 2095-2105 [PMID: 35321188 DOI: 10.12998/wjcc.v10.i7.2095]
34
"I consider this manuscript is of a topic of great importance, such as pain management in critically ill patients in intensive care units. Pain management is a process of continuous quality improvement that requires multidisciplinary team cooperation, pain-related training of all relevant personnel, effective relief of all kinds of pain, and improvement of patients' quality of life. Knowing the types of pain and risk factors will help to provide an individualized pain management based on pharmacokinetics and pharmacodynamics. " 
Guo NN, Wang HL, Zhao MY, Li JG, Liu HT, Zhang TX, Zhang XY, Chu YJ, Yu KJ, Wang CS. Management of procedural pain in the intensive care unit. World J Clin Cases 2022; 10(5): 1473-1484 [PMID: 35211585 DOI: 10.12998/wjcc.v10.i5.1473]
35
"All comments are presented our in our submitted letter to the editor" 
Rubin SJS, Balabanis T, Gubatan J, Habtezion A. Disease exacerbation is common in inflammatory bowel disease patients treated with immune checkpoint inhibitors for malignancy. World J Clin Cases 2022; 10(6): 1787-1794 [PMID: 35317167 DOI: 10.12998/wjcc.v10.i6.1787]
36
"Artificial intelligence in colorectal cancer screening in patients with inflammatory bowel disease Thank you for inviting me to comment on the above-titled manuscript. First, I congratulate the authors on their publication. However, I have a few comments and suggestions- Abstract- I suggest instead of the descriptive statements, the authors may need to address 3 points: 1) What are current tools used to detect CRC in patients with IBD early? 2) What are the main limitations of these tools? 3) How AI can help in filling the gap? The section on (AI in Gastrointestinal Endoscopy) is redundant and is away from the scope of the review. Instead, the authors should have addressed the 3 questions presented above. Thank you " 
Marques KF, Marques AF, Lopes MA, Beraldo RF, Lima TB, Sassaki LY. Artificial intelligence in colorectal cancer screening in patients with inflammatory bowel disease. Artif Intell Gastrointest Endosc 2022; 3(1): 1-8 [DOI: 10.37126/aige.v3.i1.1]
37
"The manuscript is well written and dwells into details of a relatively uncommonly encountered medical diagnosis. " 
Lee YJ, Kim YS. Cryptogenic organizing pneumonia associated with pregnancy: A case report. World J Clin Cases 2022; 10(6): 1946-1951 [PMID: 35317155 DOI: 10.12998/wjcc.v10.i6.1946]
38
"The authors do a good job of explaining the pathophysiology and diagnosis of Tubercular Pericarditis which is disease that is uncommonly encountered" 
Lucero OD, Bustos MM, Ariza Rodríguez DJ, Perez JC. Tuberculous pericarditis-a silent and challenging disease: A case report. World J Clin Cases 2022; 10(6): 1869-1875 [PMID: 35317150 DOI: 10.12998/wjcc.v10.i6.1869]
39
"There are many studies on the overproduction of reactive oxygen species (ROS) in liver toxicity and chronic liver disease resulting in oxidative stress and endoplasmic reticulum stress. The study of Silvia Bona et al., is among these. The authors have evaluated the damage induced by CCL4 administration to rats and the effect on the liver toxicity of melatonin, the hormone derives from the amino acid tryptophan and is produced by the pineal gland, with a variety of effects on mood, sleep, reproduction, immune system, circadian rhythm, aging and thus modulating antioxidant defense system. The biochemical analysis indicates that the transaminases and alkaline phosphatase were increased in CCL4 –treated animals and Melatonin was able to bring the levels of enzyme activities back to basal. Melatonin also was able to restore the peroxidation markers, LPO and SOD activity as well as the protein markers related to oxidative stress Keap1/Nrf2 pathway. An here comes the more original part of the article of Bona et al., a less common parameter, such as endoplasmic reticulum stress and the protein folding were also taken into account, measuring the markers of ER stress: ATF6 and GRP78/BiP. Redox stress impair the protein synthesis resulting in accumulation of misfolded proteins. The expression of these proteins was increased in CCL4- treated animals and melatonin was able to restore the levels to basal. Unfolded proteins are very toxic due to their capability to aggregate, therefore eukariotic cells have evolved systems able to prevent excessive accumulation of proteins in the endoplasmic reticulum that may give rise to a complex reaction called unfolded protein response (UPR). UPR in turn gives rise to an increased transcription of the specific genes leading to the synthesis of chaperones proteins of ER or they may slow down the synthesis of the new proteins, to keep it low and reduce aggregation. Other parameters very important for cellular proteins to keep low the excessive redox levels and protein folding are Heat Shock Proteins (HSP) and the nuclear Heat Shock Factor 1 (HSF1). Among heat shock proteins, a protein family most conserved in evolution expressed both constitutively and inducibly is the HSP70. Another interesting paramenter studied by Bona et al.,in addition to the biochemical parameters measured is the level of Zinc. Zinc is a very important micronutrient essential for human health starting from protein physiology and function (i.e.insulin) up to oxidative markers and its dysregulation may be an important determinant of several pathologies such as anemia, growth retardation, skin alteration , mental impairment, macular degeneration, blindness. Zinc deficiency impairs situations of oxidative stress and its markers. The zinc levels was dramatically decreased in cytotoxic hepatocytes, but melatonin restored its level to normal control value, confirming once more its efficiency, not only as an antioxidant. Melatonin is probably able to modulate zinc level and its association to circadian rhythm. To summarize, the paper of Bona et al., has a very good consistency since the authors take into account not only the known biochemical parameters, but also zinc levels, a micronutrient essential for human health, and UPR, very important to know how the membrane-bound transcription factors as well as the cell function and structure are regulated. " 
Bona S, Fernandes SA, Moreira ACJ, Rodrigues G, Schemitt EG, Di Naso FC, Marroni CA, Marroni NP. Melatonin restores zinc levels, activates the Keap1/Nrf2 pathway, and modulates endoplasmic reticular stress and HSP in rats with chronic hepatotoxicity. World J Gastrointest Pharmacol Ther 2022; 13(2): 11-22 [PMID: 35433098 DOI: 10.4292/wjgpt.v13.i2.11]
40
"It would have been nice to separate as three big topics: initiation, promotion, and progression. Anyhow, it is an interesting review." 
Currais P, Rosa I, Claro I. Colorectal cancer carcinogenesis: From bench to bedside. World J Gastrointest Oncol 2022; 14(3): 654-663 [PMID: 35321283 DOI: 10.4251/wjgo.v14.i3.654]
41
"Concise and effective letter. Shareable its content" 
Okumura K. Re: Association between intestinal neoplasms and celiac disease - beyond celiac disease and more. World J Gastrointest Oncol 2022; 14(3): 746-747 [PMID: 35321274 DOI: 10.4251/wjgo.v14.i3.746]
42
"In my opinion, the limitation of this minireview is that the topic is treated in a too generalist way, the reader receives some information that in truth is not explained in depth. Finally, the references are not quite recent, as one would expect from such an innovative topic. However, it is a minireview and this could be enough to create sufficient interest and stimulus to the reader" 
Burati M, Tagliabue F, Lomonaco A, Chiarelli M, Zago M, Cioffi G, Cioffi U. Artificial intelligence as a future in cancer surgery. Artif Intell Cancer 2022; 3(1): 11-16 [DOI: 10.35713/aic.v3.i1.11]
43
"The authors of the article evaluate the efficacy and safety of radiofrequency ablation (RFA) for gastric low-grade intraepithelial neoplasia. They describe the RFA procedure in detail and assess factors associated with the risk of disease recurrence. The identification of these factors is important, as it allows us optimizing the choice of treatment methods in patients and opens up opportunities for preventing disease recurrence through anti-Helicobacter therapy. The article is of undoubted interest to clinicians." 
Wang NJ, Chai NL, Tang XW, Li LS, Zhang WG, Linghu EQ. Clinical efficacy and prognostic risk factors of endoscopic radiofrequency ablation for gastric low-grade intraepithelial neoplasia. World J Gastrointest Oncol 2022; 14(3): 724-733 [PMID: 35321273 DOI: 10.4251/wjgo.v14.i3.724]
44
"This is an important study comparing gastric cancer in Asian and Western countries." 
Chiarello MM, Fico V, Pepe G, Tropeano G, Adams NJ, Altieri G, Brisinda G. Early gastric cancer: A challenge in Western countries. World J Gastroenterol 2022; 28(7): 693-703 [PMID: 35317273 DOI: 10.3748/wjg.v28.i7.693]
45
"This is an interesting study on the relationship between lipid synthesis and cancer stem cells." 
Wang SY, Hu QC, Wu T, Xia J, Tao XA, Cheng B. Abnormal lipid synthesis as a therapeutic target for cancer stem cells. World J Stem Cells 2022; 14(2): 146-162 [PMID: 35432735 DOI: 10.4252/wjsc.v14.i2.146]
46
"Treatment for HCC with portal vein involvement is challenging for doctors whom it concerns. This mini-review reveals encouraging results of the combination of surgery and radiation therapy. As the author mentions in future perspective, progress in chemotherapy may play an important role near future." 
Choe JW, Lee HY, Rim CH. Will the collaboration of surgery and external radiotherapy open new avenues for hepatocellular carcinoma with portal vein thrombosis? World J Gastroenterol 2022; 28(7): 704-714 [PMID: 35317274 DOI: 10.3748/wjg.v28.i7.704]
47
"This is a very well written review of the current literature regarding the data related to DAA association with de novo HCC occurrence / recurrence and possible pathophysiology of HCC related to DAAs. The discussion and data presentation are concise and clear, whereas more evidence is needed for further conclcions about the subject. " 
Kamal A, Elsheaita A, Abdelnabi M. Association between direct-acting antiviral agents in hepatitis C virus treatment and hepatocellular carcinoma occurrence and recurrence: The endless debate. World J Clin Cases 2022; 10(6): 1764-1774 [PMID: 35317156 DOI: 10.12998/wjcc.v10.i6.1764]
48
"In general, it is a well written manuscript about a medical entity that is not so common, but poses serious threats and warrants special medical treatment. The authors have presented all the relative clinical data about the patient and discussed some important aspects of diagnosis and management. Nevertheless, they could also present (if possible) some laboratory exams of this patient for discussion (ex. blood tests). Moreover, they could also present some evidence about the differential diagnosis and prognosis." 
Lucero OD, Bustos MM, Ariza Rodríguez DJ, Perez JC. Tuberculous pericarditis-a silent and challenging disease: A case report. World J Clin Cases 2022; 10(6): 1869-1875 [PMID: 35317150 DOI: 10.12998/wjcc.v10.i6.1869]
49
"The authors studied the utility of TXI for adenomas as the target lesions. The results showed that TXI was inferior to NBI in all visibility parameters: tumor margin, vessel pattern, and surface pattern. Similar to LCI, TXI may contribute to the improved adenoma detection rate, but the utility of TXI is likely to be limited at this time." 
Toyoshima O, Nishizawa T, Yoshida S, Yamada T, Odawara N, Matsuno T, Obata M, Kurokawa K, Uekura C, Fujishiro M. Texture and color enhancement imaging in magnifying endoscopic evaluation of colorectal adenomas. World J Gastrointest Endosc 2022; 14(2): 96-105 [PMID: 35316981 DOI: 10.4253/wjge.v14.i2.96]
50
" The article systematically bring out the efficacy of combination of radiotherapy and surgery of treating hepatocellular carcinoma with portal invasion. " 
Choe JW, Lee HY, Rim CH. Will the collaboration of surgery and external radiotherapy open new avenues for hepatocellular carcinoma with portal vein thrombosis? World J Gastroenterol 2022; 28(7): 704-714 [PMID: 35317274 DOI: 10.3748/wjg.v28.i7.704]