| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Hypoallergenic formula with Lactobacillus rhamnosus GG for babies with colic: A pilot study of recruitment, retention, and fecal biomarkers
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Nicole Y Fatheree, Yuying Liu, Michael Ferris, Melissa Van Arsdall, Valarie McMurtry, Marcela Zozaya, Chunyan Cai, Mohammad H Rahbar, Manouchehr Hessabi, Ta Vu, Christine Wong, Juleen Min, Dat Q Tran, Fernando Navarro, Wallace Gleason, Sara Gonzalez and J Marc Rhoads |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| An Investigator Initiated Trial grant from Mead Johnson Nutrition which had no influence on the design or conduct of the study, data management and analysis, writing of the report, or the decision to submit the manuscript for publication |
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| Corresponding Author |
J Marc Rhoads, MD, Department of Pediatrics, the University of Texas Health Science Center at Houston Medical School, 6431 Fannin St., MSB 3.137, Houston, TX 77030, United States. j.marc.rhoads@uth.tmc.edu |
| Key Words |
Barr diary; Regulatory T cells; Cytokines; Crying; Fussing; Probiotic; Inflammation; Biomarker; Newborn; Intestine |
| Core Tip |
The “dysbiosis” theory proposes that newborns with abnormal colonization are predisposed to having gut inflammation and colic. Probiotics may reduce crying and diversify the fecal microbiota. A prospective, double-blind, placebo-controlled trial was conducted in healthy infants with colic. After 75% screen failure or dropouts, 20 infants were analyzed (9 receiving formula with Lactobacillus GG and 11 not receiving Lactobacillus rhamnosus GG in their formula). We found that: (1) recruitment/retention indicate future randomized controlled trials should enroll 80 patients with an optimal timepoint for observing a potential difference in crying at 14 d; (2) microbial communities were chaotic in infants with colic, even more so than reported in Dutch infants; and (3) our study was the first to analyze cytokine levels and circulating Tregs in infants with colic. |
| Publish Date |
2016-01-31 16:11 |
| Citation |
Fatheree NY, Liu Y, Ferris M, Van Arsdall M, McMurtry V, Zozaya M, Cai C, Rahbar MH, Hessabi M, Vu T, Wong C, Min J, Tran DQ, Navarro F, Gleason W, Gonzalez S, Rhoads JM. Hypoallergenic formula with Lactobacillus rhamnosus GG for babies with colic: A pilot study of recruitment, retention, and fecal biomarkers. World J Gastrointest Pathophysiol 2016; 7(1): 160-170 |
| URL |
http://www.wjgnet.com/2150-5330/full/v7/i1/160.htm |
| DOI |
http://dx.doi.org/10.4291/wjgp.v7.i1.160 |
