Publication Name	World Journal of Gastroenterology
Manuscript ID	18549
Country	China

Received	2015-04-23 16:58
Peer-Review Started	2015-04-24 16:29
To Make the First Decision	2015-06-02 16:14
Return for Revision	2015-06-07 18:00
Revised	2015-06-17 09:31
Second Decision	2015-07-17 17:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-07-18 11:21
Articles in Press	2015-07-18 11:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-08-09 17:28
Typeset the Manuscript	2015-08-31 16:49
Publish the Manuscript Online	2015-09-28 11:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Biochemical Research Methods
Manuscript Type	Basic Study
Article Title	Equol inhibits proliferation of human gastric carcinoma cells via modulating Akt pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Ping Yang, Yan Zhao, Fang Huang, Jie Chen, Ya-Hong Yao, Jun Li and Xiao-Nan Wu
Funding Agency and Grant Number	Funding Agency Grant Number Special Project on the Integration of Industry, Education and Research of Fujian Province, China 2012N0014
Corresponding Author	Xiao-nan Wu, Professor, Public Health College, Fujian Medical University, No. 1 Xueyuan Road, Fuzhou 350108, Fujian Province, China. wuxiaonan728@163.com
Key Words	Equol; Apoptosis; Chemoprevention; Gastric cancer; G0/G1 arrest
Core Tip	The results of our study demonstrated that equol could effectively inhibit the proliferation of human gastric cancer MGC-803 cells, which was associated with cell cycle arrest and apoptosis. Our data also suggested that the Akt signaling pathway may play a role in equol-mediated cell cycle arrest. To our knowledge, this is the first study demonstrating that equol exerts anticancer effect in human gastric cancer cells and that blockade of the Akt signaling pathway may be an antitumor mechanism of equol.
Publish Date	2015-09-28 11:42
Citation	Yang ZP, Zhao Y, Huang F, Chen J, Yao YH, Li J, Wu XN. Equol inhibits proliferation of human gastric carcinoma cells via modulating Akt pathway. World J Gastroenterol 2015; 21(36): 10385-10399
URL	http://www.wjgnet.com/1007-9327/full/v21/i36/10385.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i36.10385

Full Article (PDF)	WJG-21-10385.pdf
Full Article (Word)	WJG-21-10385.doc
Manuscript File	18549-Review.docx
Answering Reviewers	18549-Answering reviewers.pdf
Audio Core Tip	18549-Audio core tip.mp3
Biostatistics Review Certificate	18549-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	18549-Conflict-of-interest statement.pdf
Copyright License Agreement	18549-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	18549-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	18549-Institutional review board statement.pdf
Peer-review Report	18549-Peer-review(s).pdf
Scientific Misconduct Check	18549-Scientific misconduct check.pdf
Scientific Editor Work List	18549-Scientific editor work list.pdf