Publication Name	World Journal of Biological Chemistry
Manuscript ID	19575
Country	United States

Received	2015-05-13 08:59
Peer-Review Started	2015-05-13 17:25
To Make the First Decision	2015-06-18 15:31
Return for Revision	2015-06-24 19:00
Revised	2015-07-01 03:15
Second Decision	2015-07-21 19:38
Accepted by Journal Editor-in-Chief	2015-07-21 19:43
Accepted by Company Editor-in-Chief	2015-07-27 17:20
Articles in Press	2015-07-27 17:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-11 16:53
Publish the Manuscript Online	2015-08-26 11:07

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Multifunctional facets of retrovirus integrase
Manuscript Source	Invited Manuscript
All Author List	Duane P Grandgenett, Krishan K Pandey, Sibes Bera and Hideki Aihara
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health grants from NIAID AI100682(to Grandgenett DP) National Institutes of Health grants from NIGMS GM109770(to Aihara H)
Corresponding Author	Duane P Grandgenett, Professor of Molecular Virology, Institute for Molecular Virology, Saint Louis University Health Sciences Center, 1100 S. Grand Blvd., St. Louis, MO 63104, United States. grandgdp@slu.edu
Key Words	Retrovirus integrase; Integration; Host factors; Atomic structure; Human immunodeficiency virus integrase inhibitors
Core Tip	This review examines the multifunctional properties of retrovirus integrase (IN) besides its key function of integrating the viral DNA into host chromosomes. IN has a major role in the maturation of the virus, reverse transcription and nuclear transport of the preintegration complex. IN binds to cellular cofactors for uncoating of the core and to other cellular proteins that guide the preintegration complex to preferred regions on the host genome for integration. Understanding these IN functions has resulted in the production of clinical IN strand transfer inhibitors to prevent human immunodeficiency virus (HIV/AIDS) and development of retrovirus vectors for human gene therapy.
Publish Date	2015-08-26 11:07
Citation	Grandgenett DP, Pandey KK, Bera S, Aihara H. Multifunctional facets of retrovirus integrase. World J Biol Chem 2015; 6(3): 83-94
URL	http://www.wjgnet.com/1949-8454/full/v6/i3/83.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i3.83

Full Article (PDF)	WJBC-6-83.pdf
Full Article (Word)	WJBC-6-83.doc
Manuscript File	19575-Review.docx
Answering Reviewers	19575-Answering reviewers.pdf
Audio Core Tip	19575-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19575-Conflict-of-interest statement.pdf
Copyright License Agreement	19575-Copyright assignment.pdf
Peer-review Report	19575-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19575-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19575-Scientific misconduct check.pdf
Scientific Editor Work List	19575-Scientific editor work list.pdf