Publication Name	World Journal of Transplantation
Manuscript ID	21902
Country	Germany

Received	2015-07-31 17:11
Peer-Review Started	2015-08-01 17:07
To Make the First Decision	2015-10-08 16:54
Return for Revision	2015-10-13 17:34
Revised	2015-10-21 17:50
Second Decision	2015-11-27 16:02
Accepted by Journal Editor-in-Chief	2015-11-30 00:49
Accepted by Company Editor-in-Chief	2015-12-08 15:30
Articles in Press	2015-12-08 15:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-01 11:47
Publish the Manuscript Online	2016-03-18 14:28

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Transplantation
Manuscript Type	Review
Article Title	Immunological aspects of liver cell transplantation
Manuscript Source	Invited Manuscript
All Author List	Felix Oldhafer, Michael Bock, Christine S Falk and Florian WR Vondran
Funding Agency and Grant Number	Funding Agency Grant Number German Research Foundation (DFG) SFB 738 German Research Foundation (projects B3) C11 BMBF 01EO1302
Corresponding Author	PD Dr. Florian WR Vondran, MD, Regenerative Medicine and Experimental Surgery (ReMediES), Department of General, Visceral and Transplant Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. vondran.florian@mh-hannover.de
Key Words	Liver cell transplantation; Cell-based therapy; Hepatocyte transplantation; Transplant immunology; Regenerative medicine
Core Tip	Failure of durable engraftment of transplanted hepatocytes despite application of immunosuppression is mainly attributed to the remaining recipient’s immune responses against these allogenic grafts. Immune responses significantly differ from those observed for transplantation of whole livers and other solid organs. Innate immunity in combination with adaptive immune responses by T- and B-cells have to be taken into account for liver cell transplantation-specific immunosuppressive strategies. Possible clinical solutions to these obstacles will involve new combinations of novel and established immunosuppressive and anti-inflammatory drugs, co-transplantation of other liver cell types or regulatory immune cells. In the future, also (syngenic) liver stem cells will be an option.
Publish Date	2016-03-18 14:28
Citation	Oldhafer F, Bock M, Falk CS, Vondran FWR. Immunological aspects of liver cell transplantation. World J Transplant 2016; 6(1): 42-53
URL	http://www.wjgnet.com/2220-3230/full/v6/i1/42.htm
DOI	http://dx.doi.org/10.5500/wjt.v6.i1.42

Full Article (PDF)	WJT-6-42.pdf
Full Article (Word)	WJT-6-42.doc
Manuscript File	21902-Review.docx
Answering Reviewers	21902-Answering reviewers.pdf
Audio Core Tip	21902-Audio core tip.wav
Conflict-of-Interest Disclosure Form	21902-Conflict-of-interest statement.pdf
Copyright License Agreement	21902-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20150731160502.doc
Peer-review Report	21902-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21902-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21902-Scientific misconduct check.pdf
Scientific Editor Work List	21902-Scientific editor work list.pdf