Publication Name	World Journal of Respirology
Manuscript ID	2420
Country	United States

Received	2013-02-20 09:51
Peer-Review Started	2013-02-20 16:46
To Make the First Decision	2013-03-18 15:31
Return for Revision	2013-03-19 11:39
Revised	2013-05-15 00:22
Second Decision	2013-06-18 10:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-06-19 00:20
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-03 11:10
Publish the Manuscript Online	2013-07-18 17:49

ISSN	2218-6255 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Respiratory System
Manuscript Type	Autobiography
Article Title	High-frequency electrical stimulation of cervical vagi reduces airway response to methacholine
Manuscript Source	Invited Manuscript
All Author List	Jianguo Zhuang, Daniel Bailet, Robert Curtis and Fadi Xu
Funding Agency and Grant Number	Funding Agency Grant Number National Heart, Lung, and Blood Institute, Bethesda, MD RO1 HL107462 NeuroStimulation Techologies, Inc. Albuquerque, NM
Corresponding Author	Dr. Fadi Xu, Lovelace Respiratory Research Institute, Pathophysiology Program, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, United States. fxu@lrri.org
Key Words	Bronchodilation; Acetylcholine; Airway hyperreactivity; Ovalbumin; Asthma
Core Tip	In summary, our study revealed that vagal high-frequency electrical stimulation (HES) significantly suppressed the airway response to methacholine (MCh) more greatly in the ovalbumin- than saline-treated animals, while vagal low-frequency electrical stimulation always increased airway resistance. Importantly, the HES-evoked bronchodilation during MCh challenge is concomitant with the on-and-off electrical stimulation and with no effect on cardiovascular activity. These, along with the greatly blunted airway resistance response to MCh after bivagotomy, suggest that vagal HES may be a potentially useful approach in alleviating asthmatic bronchoconstriction (likely via reversible inhibition or blockade of the vagal nerve conduction).
Publish Date	2013-07-18 17:49
Citation	Zhuang J, Bailet D, Curtis R, Xu F. High-frequency electrical stimulation of cervical vagi reduces airway response to methacholine. World J Respirol 2013; 3(2): 11-19
URL	http://www.wjgnet.com/2218-6255/full/v3/i2/11.htm
DOI	http://dx.doi.org/10.5320/wjr.v3.i2.11

Full Article (PDF)	WJR-3-11.pdf
Manuscript File	2420-Review.docx
Answering Reviewers	2420-Answering reviewers.docx
Copyright License Agreement	2420-Copyright assignment.pdf
Peer-review Report	2420-Peer review(s).pdf
Scientific Editor Work List	2420-Scientific editor work list.doc