Publication Name	World Journal of Gastroenterology
Manuscript ID	25769
Country	United States

Received	2016-03-22 10:23
Peer-Review Started	2016-03-22 17:43
To Make the First Decision	2016-04-14 10:09
Return for Revision	2016-04-14 14:05
Revised	2016-04-26 00:00
Second Decision	2016-05-11 15:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-05-23 16:28
Articles in Press	2016-05-23 16:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-05-27 08:47
Publish the Manuscript Online	2016-06-21 18:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Avoiding hepatic metastasis naturally: Lessons from the cotton top tamarin (Saguinus oedipus)
Manuscript Source	Invited Manuscript
All Author List	Martin Tobi, Peter Thomas and Daniel Ezekwudo
Funding Agency and Grant Number
Corresponding Author	Martin Tobi, MB, ChB, Department of Surgery, Aleda E. Lutz VAMC, 1500 Weiss Street, Saginaw, MI 48601, United States. martin.tobi@va.gov
Key Words	Cotton top tamarin; Hepatic metastasis; Carcinoembryonic antigen; Fibulin-5; Common marmoset
Core Tip	Hepatic metastasis is a terminal event. Avoiding this complication would prolong life and current understanding of inflammatory mediators allows possible secondary intervention. The cotton top tamarin (CTT), like humans develops inflammatory bowel disease complicated by colorectal cancer but avoids liver metastasis. We suggest 5 mechanisms by which CTT avoid liver spread. They involve changes in ICAMs and their receptors, carcinoembryonic antigen (CEA) family mediators of angiogenesis, post translational modifications of molecules like CEA, and increased expression of anti-proliferative agents such as fibulins. This changes our perception from “monkey see, monkey do” to “see what the monkeys do and do the same”. Possible avenues of intervention are suggested.
Publish Date	2016-06-21 18:11
Citation	Tobi M, Thomas P, Ezekwudo D. Avoiding hepatic metastasis naturally: Lessons from the cotton top tamarin (Saguinus oedipus). World J Gastroenterol 2016; 22(24): 5479-5494
URL	http://www.wjgnet.com/1007-9327/full/v22/i24/5479.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i24.5479

Full Article (PDF)	WJG-22-5479.pdf
Full Article (Word)	WJG-22-5479.doc
Manuscript File	25769-Review.docx
Answering Reviewers	25769-Answering reviewers.pdf
Audio Core Tip	25769-Audio core tip.mov
Conflict-of-Interest Disclosure Form	25769-Conflict-of-interest statement.pdf
Copyright License Agreement	25769-Copyright assignment.pdf
Peer-review Report	25769-Peer-review(s).pdf
Scientific Misconduct Check	25769-Scientific misconduct check.pdf
Scientific Editor Work List	25769-Scientific editor work list.pdf