Publication Name	World Journal of Clinical Cases
Manuscript ID	2678
Country	United States

Received	2013-03-06 20:58
Peer-Review Started	2013-03-07 15:15
To Make the First Decision	2013-03-25 15:16
Return for Revision	2013-03-28 17:09
Revised	2013-04-02 08:21
Second Decision	2013-05-07 17:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-05-08 09:25
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-05 21:21
Publish the Manuscript Online	2013-06-14 17:45

ISSN	2307-8960 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Monitoring photodynamic therapy of head and neck malignancies with optical spectroscopies
Manuscript Source	Invited Manuscript
All Author List	Ulas Sunar
Funding Agency and Grant Number	Funding Agency Grant Number RPCI Startup P30CA16056 NCI CA55791
Corresponding Author	Ulas Sunar, PhD, Department of Cell Stress Biology and Oncology, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, United States. ulas.sunar@roswellpark.org
Key Words	Head and neck cancer; Photodynamic therapy; Monitoring and predicting response; Blood flow; Oxygenation; Oxygen metabolism; Diffuse optical imaging
Core Tip	Most treatment approaches including chemo-radiation and surgery can induce prolonged morbidity and functional loss resulting in severe impairment of patients’ quality of life. Photodynamic therapy (PDT) is an emerging alternative treatment option without any significant accumulative side effects due to targeted light illumination and preferential accumulation of photosensitizers (PSs). However, PDT has not found widespread applications at the clinic mainly due to variable responses that originated from unstandardized treatment protocols such as different light and PS doses. Novel optical imaging techniques can quantify PDT-dosimetry related parameters such as local light and PS dose in tissue and PDT response related parameters such as tissue oxygenation and blood flow noninvasively without any contrast agent administration, thereby providing real-time feedback about the treatment efficacy for optimizing and standardizing PDT.
Publish Date	2013-06-14 17:45
Citation	Sunar U. Monitoring photodynamic therapy of head and neck malignancies with optical spectroscopies. World J Clin Cases 2013; 1(3): 96-105
URL	http://www.wjgnet.com/2307-8960/full/v1/i3/96.htm
DOI	http://dx.doi.org/10.12998/wjcc.v1.i3.96

Full Article (PDF)	WJCC-1-96.pdf
Manuscript File	2678-Review.docx
Answering Reviewers	2678-Answering reviewers.docx
Copyright License Agreement	2678-Copyright assignment.pdf
Peer-review Report	2678-Peer review(s).pdf
Scientific Editor Work List	2678-Scientific editor work list.doc