Publication Name	World Journal of Hepatology
Manuscript ID	27494
Country	Argentina

Received	2016-06-01 08:38
Peer-Review Started	2016-06-01 09:09
To Make the First Decision	2016-07-20 16:48
Return for Revision	2016-07-21 11:36
Revised	2016-07-28 22:46
Second Decision	2016-09-07 14:49
Accepted by Journal Editor-in-Chief	2016-09-10 23:40
Accepted by Company Editor-in-Chief	2016-09-18 14:39
Articles in Press	2016-09-18 14:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-16 18:22
Publish the Manuscript Online	2016-11-25 09:02

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Performance of cold-preserved rat liver Microorgans as the biological component of a simplified prototype model of bioartificial liver
Manuscript Source	Invited Manuscript
All Author List	María Dolores Pizarro, María Gabriela Mediavilla, Alejandra Beatriz Quintana, Ángel Luis Scandizzi, Joaquín Valentín Rodriguez and María Eugenia Mamprin
Funding Agency and Grant Number	Funding Agency Grant Number Universidad Nacional de Rosario (UNR) 677/2013
Corresponding Author	María Eugenia Mamprin, PhD, Professor of Pharmacology, Área Farma­cología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario S2002 LRK, Argentina. mmamprin@fbioyf.unr.edu.ar
Key Words	Rat liver Microorgans; Cold preservation; BG35 preservation solution; Bioartificial liver device; Acute liver failure
Core Tip	This work describes the development of a simplified bioartiticial liver prototype (BAL, suitable to use rat liver Microorgans (LMOs) as biological component, and the evaluation of these tissue slices performance in this new model. We demonstrate that the minibioreactor constructed allows a good performance of fresh and cold preserved LMOs, showing the importance of architecture and model configuration on these devices design. Besides its application as BAL, this minibioreactor could serve as a suitable laboratory tool to evaluate the behavior and functionality of LMOs subjected to different preservation protocols due to its simple design and the utilization of standard materials.
Publish Date	2016-11-25 09:02
Citation	Pizarro MD, Mediavilla MG, Quintana AB, Scandizzi ÁL, Rodriguez JV, Mamprin ME. Performance of cold-preserved rat liver Microorgans as the biological component of a simplified prototype model of bioartificial liver. World J Hepatol 2016; 8(33): 1442-1451
URL	http://www.wjgnet.com/1948-5182/full/v8/i33/1442.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i33.1442

Full Article (PDF)	WJH-8-1442.pdf
Full Article (Word)	WJH-8-1442.doc
Manuscript File	27494-Review.doc
Answering Reviewers	27494-Answering reviewer.pdf
Audio Core Tip	27494-Audio core tip.mp3
Biostatistics Review Certificate	27494-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	27494-Conflict-of-interest statement.pdf
Copyright License Agreement	27494-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	27494-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	27494-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	27494-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	27494-Language certificate.pdf
Peer-review Report	27494-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	27494-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	27494-Scientific misconduct check.pdf
Scientific Editor Work List	27494-Scientific editor work list.pdf