Publication Name	World Journal of Gastroenterology
Manuscript ID	28634
Country	Hungary

Received	2016-07-08 08:52
Peer-Review Started	2016-07-11 16:59
To Make the First Decision	2016-07-29 16:27
Return for Revision	2016-08-02 16:42
Revised	2016-08-04 04:37
Second Decision	2016-08-17 13:43
Accepted by Journal Editor-in-Chief	2016-08-17 14:37
Accepted by Company Editor-in-Chief	2016-08-23 17:11
Articles in Press	2016-08-23 17:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-05 17:41
Publish the Manuscript Online	2016-09-14 19:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases
Manuscript Source	Invited Manuscript
All Author List	Ferenc Sipos, Gábor Firneisz and Györgyi Műzes
Funding Agency and Grant Number
Corresponding Author	Ferenc Sipos, MD, PhD, 2nd Department of Internal Medicine, Semmelweis University, Szentkirályi street 46., H-1088 Budapest, Hungary. dr.siposf@gmail.com
Key Words	c-MYC; Therapy; Apoptosis; Autophagy; Colon; Inflammation; Colorectal cancer
Core Tip	The c-MYC gene is frequently deregulated in colonic inflammation, and overexpressed in both sporadic and colitis-associated colon adenocarcinomas. Endogenous c-MYC is essential for efficient induction of p53-dependent apoptosis following DNA damage, moreover its function is also involved in and regulated by autophagy-related mechanisms, and its expression is affected by DNA-methylation, or histone acetylation. Increasing our knowledge about MYC-dependent pathways might provide direction to novel colonic anti-inflammatory and anti-cancer strategies.
Publish Date	2016-09-14 19:04
Citation	Sipos F, Firneisz G, Műzes G. Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases. World J Gastroenterol 2016; 22(35): 7938-7950
URL	http://www.wjgnet.com/1007-9327/full/v22/i35/7938.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i35.7938

Full Article (PDF)	WJG-22-7938.pdf
Full Article (Word)	WJG-22-7938.doc
Manuscript File	28634-Review.doc
Answering Reviewers	28634-Answering reviewers.pdf
Audio Core Tip	28634-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	28634-Conflict-of-interest statement.pdf
Copyright License Agreement	28634-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	28634-Language certificate.pdf
Peer-review Report	28634-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	28634-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	28634-Scientific misconduct check.pdf
Scientific Editor Work List	28634-Scientific editor work list.pdf