| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
In vivo and ex vivo confocal endomicroscopy of pancreatic cystic lesions: A prospective study
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Somashekar G Krishna, Rohan M Modi, Amrit K Kamboj, Benjamin Swanson, Phil A Hart, Mary E Dillhoff, Andrei Manilchuk, Carl R Schmidt and Darwin L Conwell |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| American College of Gastroenterology Pilot Research Grant. The Gastroflex UHD probe for the ex vivo evaluation was provided by Cellvizio, Mauna Kea Technologies, Paris, France. |
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| Corresponding Author |
Somashekar G Krishna, MD, MPH, Assistant Professor, Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, 395 W. 12th Avenue, Suite 262, Columbus, Oh 43210, United States. somashekar.krishna@osumc.edu |
| Key Words |
Confocal laser endomicroscopy; Serous cystadenoma; Pancreatic neuroendocrine tumor; Intraductal papillary mucinous neoplasm; Pancreatic cystic neoplasm |
| Core Tip |
We performed a prospective study to investigate the reproducibility of in vivo endoscopic ultrasound (EUS) - guided needle based confocal endomicroscopy (nCLE) image patterns in an ex vivo setting and compare these to surgical histopathology for pancreatic cystic lesions (PCLs). A total of 10 subjects underwent in vivo EUS-nCLE and subsequently ex vivo CLE of the PCL following surgical resection. Biopsies were obtained from ex vivo CLE-imaged areas for comparative histopathology. We found that characteristic in vivo nCLE patterns were observed during ex vivo pCLE of resected PCLs. Both in vivo and ex vivo CLE imaging findings correlated with surgical histopathology. These findings support the application of EUS-nCLE in the diagnosis of PCLs. |
| Publish Date |
2017-05-15 06:16 |
| Citation |
Krishna SG, Modi RM, Kamboj AK, Swanson BJ, Hart PA, Dillhoff ME, Manilchuk A, Schmidt CR, Conwell DL. In vivo and ex vivo confocal endomicroscopy of pancreatic cystic lesions: A prospective study. World J Gastroenterol 2017; 23(18): 3338-3348 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i18/3338.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i18.3338 |
