Publication Name	World Journal of Gastroenterology
Manuscript ID	36350
Country	China

Received	2017-09-23 01:27
Peer-Review Started	2017-09-23 10:16
To Make the First Decision	2017-10-11 01:01
Return for Revision	2017-10-12 09:10
Revised	2017-10-14 15:18
Second Decision	2017-10-26 04:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-10-26 18:23
Articles in Press	2017-10-26 18:23
Publication Fee Transferred	2017-10-30 11:29
Edit the Manuscript by Language Editor	2017-11-15 12:42
Typeset the Manuscript	2017-11-22 04:37
Publish the Manuscript Online	2017-11-27 02:36

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Microbiology
Manuscript Type	Basic Study
Article Title	Composition and immuno-stimulatory properties of extracellular DNA from mouse gut flora
Manuscript Source	Unsolicited Manuscript
All Author List	Ce Qi, Ya Li, Rengqiang Yu, Sheng-li Zhou, Xingguo Wang, Guowei Le, Qingzhe Jin, Hang Xiao and Jin Sun
ORCID	Author(s) ORCID Number Ce Qi http://orcid.org/0000-0001-8460-6939 Ya Li http://orcid.org/0000-0001-6406-5645 Rengqiang Yu http://orcid.org/0000-0001-6529-0158 Sheng-li Zhou http://orcid.org/0000-0002-5638-0351 Xingguo Wang http://orcid.org/0000-0002-5758-409X Guowei Le http://orcid.org/0000-0002-9241-773X Qingzhe Jin http://orcid.org/0000-0001-6651-1100 Hang Xiao http://orcid.org/0000-0001-6194-2796 Jin Sun http://orcid.org/0000-0002-8423-9216
Funding Agency and Grant Number	Funding Agency Grant Number Supported by China Postdoctoral Science Foundation 172774 Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University KLCCB-KF201603 National Natural Science Foundation of China 31201805
Corresponding Author	Jin Sun, PhD, Associate Professor, School of Food Science and Technology, Jiangnan Uinversity, 1800 Lihu avnue, Wuxi 214122, Jiangsu Province, China. sunj@jiangnan.edu.cn
Key Words	Bacterial extracellular DNA; Small intestine; Flora; Immune-stimulatory property; Mouse; Gut microbiota
Core Tip	Our results revealed that degraded bacterial genomic DNAs were mainly released by gram-negative bacteria, especially by Bacteroidales-S24-7 and Stenotrophomonas genus in mucus of mice gut. They decreased pro-inflammatory activity compared to genomic DNA of total gut flora. Our study highlights the bacteria derived DNAs play an important role in modulating local immune response in mice gut.
Publish Date	2017-11-27 02:36
Citation	Qi C, Li Y, Yu Rq, Zhou Sl, Wang Xg, Le Gw, Jin Qz, Xiao H, Sun J. Composition and immuno-stimulatory properties of extracellular dna from mouse gut flora. World J Gastroenterol 2017; 23(44): 7830-7839
URL	http://www. wjgnet.com/1007-9327/full/v23/i44/7830.htm
DOI	http://dx.doi. org/10.3748/wjg.v23.i44.7830

Full Article (PDF)	WJG-23-7830.pdf
Full Article (Word)	WJG-23-7830.doc
Manuscript File	36350-Review.docx
Answering Reviewers	36350-Answering reviewers.pdf
Audio Core Tip	36350-Audio core tip.mp3
Biostatistics Review Certificate	36350-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	36350-Conflict-of-interest statement.pdf
Copyright License Agreement	36350-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	36350-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	36350-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	36350-Institutional Review Board Statement.pdf
Non-Native Speakers of English Editing Certificate	36350-Language certificate.pdf
Supplementary Material	36350-Supplementary material.pdf
Peer-review Report	36350-Peer-review(s).pdf
Scientific Misconduct Check	36350-Scientific misconduct check.pdf
Scientific Editor Work List	36350-Scientific editor work list.pdf