Publication Name	World Journal of Gastroenterology
Manuscript ID	36511
Country	Japan

Received	2017-10-26 01:37
Peer-Review Started	2017-10-26 12:57
To Make the First Decision	2017-11-22 01:00
Return for Revision	2017-11-27 08:41
Revised	2017-11-30 12:55
Second Decision	2017-12-04 08:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-12-04 19:53
Articles in Press	2017-12-04 19:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-12-14 02:06
Publish the Manuscript Online	2017-12-20 02:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Association between white opaque substance under magnifying colonoscopy and lipid droplets in colorectal epithelial neoplasms
Manuscript Source	Invited Manuscript
All Author List	Keisuke Kawasaki, Makoto Eizuka, Shotaro Nakamura, Masaki Endo, Shunichi Yanai, Risaburo Akasaka, Yosuke Toya, Yasuko Fujita, Noriyuki Uesugi, Kazuyuki Ishida, Tamotsu Sugai and Takayuki Matsumoto
ORCID	Author(s) ORCID Number Keisuke Kawasaki http://orcid.org/orcid.org/0000-0003-2645-4417 Makoto Eizuka http://orcid.org/orcid.org/0000-0003-4815-1273 Shotaro Nakamura http://orcid.org/orcid.org/0000-0001-8166-2599 Masaki Endo http://orcid.org/orcid.org/0000-0001-7249-2540 Shunichi Yanai http://orcid.org/orcid.org/0000-0003-1871-2412 Risaburo Akasaka http://orcid.org/orcid.org/0000-0001-7087-3016 Yosuke Toya http://orcid.org/orcid.org/0000-0002-0990-9304 Yasuko Fujita http://orcid.org/orcid.org/0000-0002-3988-9076 Noriyuki Uesugi http://orcid.org/orcid.org/0000-0002-4388-6660 Kazuyuki Ishida http://orcid.org/orcid.org/0000-0002-2804-4588 Tamotsu Sugai http://orcid.org/orcid.org/0000-0002-4896-3557 Takayuki Matsumoto http://orcid.org/orcid.org/0000-0001-9786-3854
Funding Agency and Grant Number
Corresponding Author	Keisuke Kawasaki, MD, PhD, Doctor, Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University, 19-1, Uchimaru, Morioka 020-8505, Japan. kkeisuke@iwate-med.ac.jp
Key Words	White opaque substance; Adipophilin; Magnifying narrow-band imaging; Colorectal neoplasm; Magnifying endoscopy
Core Tip	We investigated the association between the distribution of the lipid droplets and endoscopically-verified white opaque substance (WOS) in colore­ctal neoplasms. The incidence of deep adipophilin expression was higher in WOS-positive lesions than in WOS-negative lesions. The incidence of deep expression was predominant among cancers with massive submu­cosal invasion compared to adenoma and high-grade dysplasia or cancers with slight submucosal invasion. We thus concluded that the distribution of lipid droplets may be closely associated with the visibility of WOS, and also with histologic grade and depth of tumor invasion.
Publish Date	2017-12-20 02:49
Citation	Kawasaki K, Eizuka M, Nakamura S, Endo M, Yanai S, Akasaka R, Toya Y, Fujita Y, Uesugi N, Ishida K, Sugai T, Matsumoto T. Association between white opaque substance under magnifying colonoscopy and lipid droplets in colorectal epithelial neoplasms. World J Gastroenterol 2017; 23(47): 8367-8375
URL	http://www.wjgnet.com/1007-9327/full/v23/i47/8367.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i47.8367

Full Article (PDF)	WJG-23-8367.pdf
Full Article (Word)	WJG-23-8367.doc
Manuscript File	36511-Review.docx
Answering Reviewers	36511-Answering reviewers.pdf
Audio Core Tip	36511-Audio core tip.mp3
Biostatistics Review Certificate	36511-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	36511-Conflict-of-interest statement.pdf
Copyright License Agreement	36511-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	36511-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	36511-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	36511-Language certificate.pdf
Peer-review Report	36511-Peer-review(s).pdf
Scientific Editor Work List	36511-Scientific editor work list.pdf