Publication Name	World Journal of Gastroenterology
Manuscript ID	3808
Country	China

Received	2013-05-25 10:05
Peer-Review Started	2013-05-25 19:08
To Make the First Decision	2013-07-26 18:36
Return for Revision	2013-07-29 19:27
Revised
Second Decision	2013-10-21 17:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-10-22 07:09
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-13 18:29
Typeset the Manuscript	2013-11-21 18:46
Publish the Manuscript Online	2013-12-11 16:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Autobiography
Article Title	siRNA-targeted inhibition of growth hormone receptor in human colon cancer SW480 cells
Manuscript Source	Invited Manuscript
All Author List	Dong Zhou, Jie Yang, Wei-Dong Huang, Jun Wang and Qiang Zhang
Funding Agency and Grant Number
Corresponding Author	Dong Zhou, MD, Department of General Surgery, Xiangyang Hospital Affiliated to Hubei University of Medicine, Xiangyang 441000, Hubei Province, China. tbw120@163.com
Key Words	Growth hormone receptor; Small interfering RNAs; Colon cancer; Gene therapy; Signaling pathway
Core Tip	Human growth hormone receptor (GHR) is highly expressed in colon cancer tissues. GH/GHR plays an important role in colon cancer emergence and development. After specific binding of GH to GHR in tumor tissues, the JAK-STAT signaling pathway is activated, resulting in improved cell growth and proliferation. small interfering RNAs (siRNAs)-targeted inhibition of the human GHR gene was used to investigate its impact on the emergence and development of colon cancer and to determine how human colon cancer cells respond to GHR suppression. The siRNA-containing plasmid could suppress GHR expression in colon cancer cells and exhibited anti-tumor effects in nude mice.
Publish Date	2013-12-11 16:13
Citation	Zhou D, Yang J, Huang WD, Wang J, Zhang Q. siRNA-targeted inhibition of growth hormone receptor in human colon cancer SW480 cells. World J Gastroenterol 2013; 19(44): 8108-8113
URL	http://www.wjgnet.com/1007-9327/full/v19/i44/8108.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i44.8108

Full Article (PDF)	WJG-19-8108.pdf
Manuscript File	3808-Review.docx
Answering Reviewers	3808-Answering reviewers.pdf
Copyright License Agreement	3808-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3808-Language certificate.pdf
Peer-review Report	3808-Peer review(s).pdf
Scientific Editor Work List	3808-Scientific editor work list.doc