Publication Name	World Journal of Respirology
Manuscript ID	5326
Country	Greece

Received	2013-08-29 14:52
Peer-Review Started	2013-08-30 13:50
To Make the First Decision	2013-09-09 14:29
Return for Revision	2013-09-11 10:26
Revised	2013-10-03 00:29
Second Decision	2013-11-18 17:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-11-19 11:20
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-20 15:20
Publish the Manuscript Online	2013-12-03 15:44

ISSN	2218-6255 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Respiratory System
Manuscript Type	Review
Article Title	Autotaxin and lysophosphatidic acid signalling in lung pathophysiology
Manuscript Source	Invited Manuscript
All Author List	Christiana Magkrioti and Vassilis Aidinis
Funding Agency and Grant Number	Funding Agency Grant Number Hellenic Ministry of Education, Lifelong Learning and Religious Affairs 09SYN-12-679/680
Corresponding Author	Dr. Vassilis Aidinis, PhD, Researcher A’, Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, 34 Fleming Street, 16672 Athens, Greece. v.aidinis@fleming.gr
Key Words	Autotaxin; Lysophosphatidic acid; Lung; Acute lung injury; Pulmonary fibrosis; Asthma; Lung cancer
Core Tip	In the lungs, autotaxin (ATX) is constitutively expressed in the bronchial epithelium, and all pulmonary cell types express some amount of lysophosphatidic acid (LPA) receptor. LPA affects all pulmonary cell types, mainly promoting a pro-inflammatory state. Increased ATX/LPA levels have been detected in various pathophysiological situations, both in mice and humans, including acute, allergic or chronic pulmonary inflammation; fibrosis; and lung cancer. Genetic or pharmacologic interventions targeting the ATX/LPA axis have proved beneficial for modelled disease management in animal models, establishing the ATX/LPA axis as a possible therapeutic target.
Publish Date	2013-12-03 15:44
Citation	Magkrioti C, Aidinis V. Autotaxin and lysophosphatidic acid signalling in lung pathophysiology. World J Respirol 2013; 3(3): 77-103
URL	http://www.wjgnet.com/2218-6255/full/v3/i3/77.htm
DOI	http://dx.doi.org/10.5320/wjr.v3.i3.77

Full Article (PDF)	WJR-3-77.pdf
Manuscript File	5326-Review.docx
Answering Reviewers	5326-Answering reviewers.pdf
Copyright License Agreement	5326-Copyright assignment.pdf
Peer-review Report	5326-Peer review(s).pdf
Scientific Editor Work List	5326-Scientific editor work list.doc