ISSN |
1948-9358 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Endocrinology & Metabolism |
Manuscript Type |
Basic Study |
Article Title |
Maternal low protein diet induces persistent expression changes in metabolic genes in male rats
|
Manuscript Source |
Invited Manuscript |
All Author List |
Allan de Oliveira Lira, José Luiz de Brito Alves, Mariana Pinheiro Fernandes, Diogo Vasconcelos, David Filipe Santana, João Henrique da Costa-Silva, Béatrice Morio, Carol Góis Leandro and Luciano Pirola |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
the CAPES/COFECUB |
797-14 |
the National Council for Research – Brazil |
477915/2012-4 |
|
Corresponding Author |
Luciano Pirola, PhD, Senior Researcher, Carmen (Cardiology, Metabolism and Nutrition) Laboratory, INSERM U1060, Lyon-1 University,South Lyon Medical Faculty Sector 2, CENS ELI-2D building, 165 Chemin du grand Revoyet, Pierre Benite 69310, France. luciano.pirola@univ-lyon1.fr |
Key Words |
Metabolic adaptation; Phenotype plasticity; Liver; Adipose tissue; Metabolism; Maternal protein undernutrition |
Core Tip |
Perinatal exposure to a poor nutritional environment predisposes to metabolic disease. Here, the expression of metabolism-related genes in adipose tissue and liver was investigated. We evaluated the alterations in gene expression of glycolytic/Krebs cycle genes, adipogenic and lipolitic genes in adipose tissue of offspring rats at 30/90 d of age, exposed to maternal low-protein diet throughout gestation/lactation. We also evaluated expression of liver transcription factors and gluconeogenic genes. Persistent gene alterations were observed, that may account for the metabolic adaptations in response to maternal low-protein diet, highlighting the occurrence of persistent transcriptional defects as a consequence of perinatal malnutrition. |
Publish Date |
2020-05-11 09:58 |
Citation |
de Oliveira Lira A, de Brito Alves JL, Pinheiro Fernandes M, Vasconcelos D, Santana DF, da Costa-Silva JH, Morio B, Góis Leandro C, Pirola L. Maternal low protein diet induces persistent expression changes in metabolic genes in male rats. World J Diabetes 2020; 11(5): 182-192 |
URL |
https://www.wjgnet.com/1948-9358/full/v11/i5/182.htm |
DOI |
https://dx.doi.org/10.4239/wjd.v11.i5.182 |