| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Prostate-specific membrane antigen expression in hepatocellular carcinoma, cholangiocarcinoma, and liver cirrhosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Xing Chen, Si-Juan Zou, Dan Li, Jian-Yuan Zhou, Zhao-Ting Cheng, Jun Zhao, Yuan-Li Zhu, Dong Kuang and Xiao-Hua Zhu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81873903, 81671718, 91959119 and 81271600 |
| Natural Science Foundation of Hubei province in China |
No. 2016CFB687 |
|
| Corresponding Author |
Xiao-Hua Zhu, MD, PhD, Professor, Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Ave, Wuhan 430030, Hubei Province, China. evazhu@vip.sina.com |
| Key Words |
Prostate-specific membrane antigen; Hepatocellular carcinoma; Cholangiocarcinoma; Liver cirrhosis; Neovasculature; Immunohistochemistry |
| Core Tip |
Immunohistochemistry was used to detect prostate-specific membrane antigen (PSMA) expression in hepatocellular carcinoma (HCC), cholangiocellular carcinoma (CCA) and liver cirrhosis. PSMA is specifically expressed in tumor-associated vasculature in HCC and CCA. The positive rate of PSMA staining in HCC was significantly higher than that in CCA (86.8% vs 79.3%), meanwhile, only 6.6% in liver cirrhosis, thus the potential of using PSMA-targeted imaging to distinguish HCC from liver cirrhosis may be true. PSMA expression correlated positively with stage and grade both in HCC and CCA, high staining intensity of PSMA was more frequently observed in liver cancers at high grade and advanced stage. |
| Publish Date |
2020-12-25 10:20 |
| Citation |
Chen LX, Zou SJ, Li D, Zhou JY, Cheng ZT, Zhao J, Zhu YL, Kuang D, Zhu XH. Prostate-specific membrane antigen expression in hepatocellular carcinoma, cholangiocarcinoma, and liver cirrhosis. World J Gastroenterol 2020; 26(48): 7664-7678 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i48/7664.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i48.7664 |
