| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Relationship between clinical remission of perianal fistulas in Crohn’s disease and serum adalimumab concentrations: A multi-center cross-sectional study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Laura Sirmai, Anne-Laure Pelletier, Nathalie Gault, Camille Zallot, Guillaume Bouguen, Dominique Bouchard, Pascale Roland Nicaise, Marine Peyneau, Sandrine Sironneau, Marcelo De Carvalho Bittencourt, Antoine Petitcollin, Pedro Fernandez, Xavier Roblin, Laurent Siproudhis and Laurent Abramowitz |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Laura Sirmai, MD, Doctor, Division of Hepato-Gastroenterology and Digestive Oncology, Bichat Claude Bernard University Hospital, 46 Rue Henri Huchard, Paris 75018, France. laura.sirmai@gmail.com |
| Key Words |
Crohn’s disease; Clinical pharmacology; Peri-anal disorders; Adalimumab |
| Core Tip |
Perianal fistulas (PAFs) are a complication of Crohn’s disease (CD) in approximately 20% of patients. Adalimumab (ADA) was shown to treat CD-associated PAFs; however, little information is available on serum ADA concentrations and their remission. We performed a cross-sectional study at four hospitals in France to investigate this relationship, including 34 patients with 56 evaluations. Fifteen patients had clinical remission (44%). Serum ADA concentrations were significantly higher in evaluations showing clinical remission compared to those without. Thus, ADA serum concentrations that are required for PAF remission should be higher compared with the previously described concentrations associated with luminal remission. |
| Publish Date |
2022-03-03 06:59 |
| Citation |
Sirmai L, Pelletier AL, Gault N, Zallot C, Bouguen G, Bouchard D, Roland Nicaise P, Peyneau M, Sironneau S, Bittencourt M, Petitcollin A, Fernandez P, Roblin X, Siproudhis L, Abramowitz L. Relationship between clinical remission of perianal fistulas in Crohn’s disease and serum adalimumab concentrations: A multi-center cross-sectional study. World J Gastroenterol 2022; 28(9): 961-972 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i9/961.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i9.961 |
