Publication Name	World Journal of Gastroenterology
Manuscript ID	6378
Country	Italy

Received	2013-10-15 15:16
Peer-Review Started	2013-10-16 14:20
To Make the First Decision	2013-12-16 17:46
Return for Revision	2013-12-18 10:37
Revised	2014-01-15 03:37
Second Decision	2014-05-05 08:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-05 09:46
Articles in Press	2014-05-23 10:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-04 17:52
Publish the Manuscript Online	2014-06-21 13:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Emerging role of the β-catenin-PPARγ axis in the pathogenesis of colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Lina Sabatino, Massimo Pancione, Carolina Votino, Tommaso Colangelo, Angelo Lupo, Ettore Novellino, Antonio Lavecchia and Vittorio Colantuoni
Funding Agency and Grant Number	Funding Agency Grant Number Ministero dell’Istruzione, Università e Ricerca, MIUR-PRIN 2010-2011 2010W7YRLZ_003
Corresponding Author	Vittorio Colantuoni, Professor, Department of Sciences and Technologies, University of Sannio, Via Port’Arsa, 11, 82100 Benevento, Italy. colantuoni@unisannio.it
Key Words	Colorectal cancer; Wnt/β-catenin pathway; Peroxisome proliferator-activated receptor γ; Genomic instability; Peroxisome proliferator activated receptor γ ligands
Core Tip	Genetic and epigenetic modifications of the Wnt/β-catenin pathway play a fundamental role in the initiation and progression of colorectal cancer (CRC). The nuclear receptor peroxisome proliferator activated receptor γ (PPARγ) acts as a differentiation-promoting transcription factor with a potential link with Wnt/β-catenin. In this review, we discuss the basic principles underlying the crosstalk between Wnt/β-catenin and PPARγ signaling, present the most recent progress in understanding as to how their alterations can culminate in CRC and, finally, suggest new hypotheses and perspectives on the identification of selective PPARγ modulators endowed with Wnt/β-catenin inhibitory effects to be used as molecular targeted drugs.
Publish Date	2014-06-21 13:56
Citation	Sabatino L, Pancione M, Votino C, Colangelo T, Lupo A, Novellino E, Lavecchia A, Colantuoni V. Emerging role of the -catenin-PPAR axis in the pathogenesis of colorectal cancer. World J Gastroenterol 2014; 20(23): 7137-7151
URL	http://www.wjgnet.com/1007-9327/full/v20/i23/7137.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i23.7137

Full Article (PDF)	WJG-20-7137.pdf
Full Article (Word)	WJG-20-7137.doc
Manuscript File	6378-Review.docx
Answering Reviewers	6378-Answering reviewers.pdf
Copyright License Agreement	6378-Copyright assignment.pdf
Peer-review Report	6378-Peer review(s).pdf
Scientific Editor Work List	6378-Scientific editor work list.pdf