| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Case Report |
| Article Title |
Maintenance treatment with infliximab for ulcerative ileitis after intestinal transplantation: A case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Takumi Fujimura, Yohei Yamada, Tomoshige Umeyama, Yumi Kudo, Hiroki Kanamori, Teizaburo Mori, Takahiro Shimizu, Mototoshi Kato, Miho Kawaida, Naoki Hosoe, Yasushi Hasegawa, Kentaro Matsubara, Naoki Shimojima, Masahiro Shinoda, Hideaki Obara, Makoto Naganuma, Yuko Kitagawa, Ken Hoshino and Tatsuo Kuroda |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| JSPS KAKENHI |
JP18K16286 |
| JSPS KAKENHI |
JP18K08600 |
|
| Corresponding Author |
Yohei Yamada, FACS, MD, PhD, Assistant Lecturer, Department of Pediatric Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. yohei.z7@keio.jp |
| Key Words |
Intestinal transplantation; Chronic ulcer; Infliximab; Crohn’s disease; Tumor necrosis factor alpha; Case report |
| Core Tip |
Infliximab binds to soluble and transmembrane forms of human tumor necrosis factor alpha (TNF-α). Ulcerative inflammatory changes in the graft under intestinal transplantation (ITx) is an often-encountered finding. However, it does not meet the criteria for so-called rejection and is close to the pathology of Crohn's disease. Studies in Crohn’s disease patients revealed that anti-TNF-α therapy provides better outcomes when combined with immunomodulatory agents and that therapeutic drug monitoring might help optimize dosing. Infliximab may be effective as a treatment for ulcerative inflammation that does not meeting the criteria for acute cell rejection not improved by immunosuppressant conditioning. The optimal management for recurrent ulcerative inflammation under ITx settings by using anti-TNF-α therapy needs further elucidation. |
| Publish Date |
2021-06-24 07:26 |
| Citation |
Fujimura T, Yamada Y, Umeyama T, Kudo Y, Kanamori H, Mori T, Shimizu T, Kato M, Kawaida M, Hosoe N, Hasegawa Y, Matsubara K, Shimojima N, Shinoda M, Obara H, Naganuma M, Kitagawa Y, Hoshino K, Kuroda T. Maintenance treatment with infliximab for ulcerative ileitis after intestinal transplantation: A case report. World J Clin Cases 2021; 9(19): 5270-5279 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i19/5270.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i19.5270 |
