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Articles Published Processes
6/24/2021 7:26:32 AM | Browse: 223 | Download: 440
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Received |
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2021-03-04 03:41 |
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Peer-Review Started |
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2021-03-04 03:41 |
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To Make the First Decision |
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Return for Revision |
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2021-04-06 12:44 |
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Revised |
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2021-04-08 14:46 |
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Second Decision |
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2021-05-19 09:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-05-19 11:54 |
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Articles in Press |
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2021-05-19 11:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-06-01 22:54 |
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Typeset the Manuscript |
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2021-06-15 14:03 |
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Publish the Manuscript Online |
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2021-06-24 07:26 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Anti-tumor effects of SMAC in ECA109 cells by regulating the expression of the inhibitor of apoptosis protein family
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ning Jiang, Wei-Quan Zhang, Hong Dong, Ying-Tao Hao, Li-Ming Zhang, Lei Shan, Xiao-Dong Yang and Chuan-Liang Peng |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Chuan-Liang Peng, MD, Chief Physician, Department of Thoracic Surgery, the Second Hospital of Shandong University, No. 247 Beiyuan Street, Jinan 250100, Shandong Province, China. pechuliang@126.com |
| Key Words |
SMAC; Esophageal cancer; ECA109 cell; Apoptosis protein; Inhibitor of apoptosis proteins family |
| Core Tip |
The poor prognosis and rising incidence of esophageal cancer highlight the need for improved therapeutic that are essential prior to treatment. The aim of this study is to explore the mechanisms by which SMAC (second mitochondrial activator of caspases) mimetics inhibit proliferation and induce apoptosis in ECA109 esophageal cancer cells. The findings support the hypothesis that LCL161 can inhibit proliferation and induce apoptosis in esophageal cancer cells ECA109 by regulating the expression of inhibitor of apoptosis proteins family, suggesting that it has potential to be an effective treatment for esophageal squamous cell carcinoma. |
| Publish Date |
2021-06-24 07:26 |
| Citation |
Jiang N, Zhang WQ, Dong H, Hao YT, Zhang LM, Shan L, Yang XD, Peng CL. Anti-tumor effects of SMAC in ECA109 cells by regulating the expression of the inhibitor of apoptosis protein family. World J Clin Cases 2021; 9(19): 5019-5027 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i19/5019.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i19.5019 |
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