| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Serum hepatitis B core-related antigen as a surrogate marker of hepatitis B e antigen seroconversion in chronic hepatitis B
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiu-Mei Chi, Xiao-Mei Wang, Zhong-Feng Wang, Rui-Hong Wu, Xiu-Zhu Gao, Hong-Qin Xu, Yan-Hua Ding and Jun-Qi Niu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science and Technology Major Project |
2017ZX10302201 |
| National Science and Technology Major Project |
2017ZX09304004 |
| National Science and Technology Major Project |
2014ZX10002002 |
| National Program on Key Basic Research Project (973 Program) |
2015CB554304 |
|
| Corresponding Author |
Jun-Qi Niu, MD, PhD, Academic Research, Dean, Director, Doctor, Professor, Research Scientist, Department of Hepatology, Key Laboratory of Zoonosis Research, Ministry Education, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130021, Jilin Province, China. junqiniu@jlu.edu.cn |
| Key Words |
Hepatitis B virus; Hepatitis B core antigens; Hepatitis B virus DNA; Detection; Liver biopsy; Pregenomic RNA; Quantitative hepatitis B core-related antigen; Receiver operating characteristics; Seroconversion; Correlation |
| Core Tip |
The mean quantitative hepatitis B core-related antigen (qHBcrAg) levels were decreased post-treatment. Serum qHBcrAg levels were positively associated with pregenomic RNA and covalently closed circular DNA levels. qHBcrAg could predict hepatitis B e antigen (HBeAg) seroconversion with an area under the receiver operating characteristics value of 0.788 at 24-wk and 0.825 at 48-wk. Log qHBcrAg at weeks 24 and 48 was independently associated with HBeAg seroconversion (odds ratio = 2.402, 95% confidence interval: 1.314-4.391, P = 0.004; odds ratio = 3.587, 95% confidence interval: 1.315-9.784, P = 0.013, respectively). |
| Publish Date |
2021-10-27 07:14 |
| Citation |
Chi XM, Wang XM, Wang ZF, Wu RH, Gao XZ, Xu HQ, Ding YH, Niu JQ. Serum hepatitis B core-related antigen as a surrogate marker of hepatitis B e antigen seroconversion in chronic hepatitis B. World J Gastroenterol 2021; 27(40): 6927-6938 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i40/6927.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i40.6927 |
