| ISSN |
2308-3840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Opinion Review |
| Article Title |
Preclinical safety, effectiveness evaluation, and screening of functional bacteria for fecal microbiota transplantation based on germ-free animals
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ya-Peng Yang, Xue-Ying Zhang, Bo-Ta Cui, Hang Zhang, Zhi-Feng Wu, Xiang Tan, Wei Cheng, Xi Zhu, Fa-Ming Zhang, Huan-Long Qin and Hong Wei |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
8177020321 |
| Emerging Cutting-Edge Technology Joint Research Projects of Shanghai |
SHDC12019114 |
|
| Corresponding Author |
Hong Wei, PhD, Professor, State Key Laboratory of Agricultural Microbiology, College of Animal Sciences and Technology, Huazhong Agricultural University, No.1 Shizishan Street, Huazhong Agricultural University, Wuhan 430070, Hubei Province, China. weihong63528@163.com |
| Key Words |
Fecal microbiota transplantation; Effectiveness; Safety; Germ-fee animals; Functional bacteria |
| Core Tip |
Gut microbiota plays an important role in the development and treatment of many diseases, especially gastrointestinal disorders. Fecal microbiota transplantation (FMT) has potential application in treating various diseases. However, the mechanism of FMT is unclear, its safety needs to be improved, and it is not standardized due to a variety of reasons. Therefore, in this review, we analyze the current dilemma of FMT and propose the importance of establishing a germ-free animal evaluation system, with an aim to help establish standard, safe, effective, controllable, and product-oriented formula flora of FMT. |
| Publish Date |
2021-12-28 09:18 |
| Citation |
Yang YP, Zhang XY, Cui BT, Zhang H, Wu ZF, Tan X, Cheng W, Zhu X, Zhang FM, Qin HL, Wei H. Preclinical safety, effectiveness evaluation, and screening of functional bacteria for fecal microbiota transplantation based on germ-free animals. World J Meta-Anal 2021; 9(6): 496-504 |
| URL |
https://www.wjgnet.com/2308-3840/full/v9/i6/496.htm |
| DOI |
https://dx.doi.org/10.13105/wjma.v9.i6.496 |
