| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Case Control Study |
| Article Title |
Genome-wide association study reveals novel loci for adult type 1 diabetes in a 5-year nested case-control study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan Gao, Shi Chen, Wen-Yong Gu, Chen Fang, Yi-Ting Huang, Yue Gao, Yan Lu, Jian Su, Ming Wu, Jun Zhang, Ming Xu and Zeng-Li Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Science Foundation for Young Scientists of China |
81602919 |
| the National Science Foundation for Young Scientists of China |
82070814 |
| the Suzhou Science and Technology Development Plan |
SYS2018099 |
| the 5th Suzhou Health Talent Program |
GSWS2019071 |
|
| Corresponding Author |
Zeng-Li Zhang, MD, PhD, Academic Fellow, Chief Doctor, Department of Occupational and Environmental Health, School of Public Health, Medical College of Soochow University, No. 199 Ren’ai Road, Suzhou 215123, Jiangsu Province, China. zhangzengli@suda.edu.cn |
| Key Words |
Type 1 diabetes; Genome-wide association study; Nested case-control study; Polymorphism |
| Core Tip |
Type 1 diabetes (T1D) is a severe and prevalent metabolic disease. Due to its high heredity, an increasing number of genome-wide association studies have been performed, most of which were from hospital-based case-control studies with a relatively small sample size. The aim of this study was to investigate the significant variants of T1D, which could be potential biomarkers for T1D prediction or even therapy. The effects of different polymorphisms in Chinese T1D patients were determined in a healthy population cohort study. The results showed 4 novel variants highly associated with the onset of T1D, namely rs3117017, rs55846421, rs75836320, and rs362071. |
| Publish Date |
2021-12-16 07:46 |
| Citation |
Gao Y, Chen S, Gu WY, Fang C, Huang YT, Gao Y, Lu Y, Su J, Wu M, Zhang J, Xu M, Zhang ZL. Genome-wide association study reveals novel loci for adult type 1 diabetes in a 5-year nested case-control study. World J Diabetes 2021; 12(12): 2073-2086 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i12/2073.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i12.2073 |
